Effect of a high fat diet on the metabolism and mechanical behaviour of the isolated rat heart
Date
1970
Authors
Reid J.V.O.
Lochner A.
Brink A.J.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The effects of a high fat, atherogenic diet was studied on the metabolism and mechanical behaviour of the isolated perfused rat heart. Palmitate and pyruvate metabolism were similar in control and fat-fed perfused hearts. Glucose uptake was lower in the fat-fed perfused heart, but the percentages of glucose converted to 14CO2 and glycogen were similar for the two groups. Explanations for the differences in glucose uptake are discussed. Fat-fed perfused hearts, with glucose as substrate, had significantly lower values for spontaneous rate, stress relaxation and tension time per minute than control hearts. With palmitate as substrate, the fat-fed perfused hearts had decreased coronary flow rates and a greater rate of tension increase on contraction. Contraction characteristics were different when hearts were perfused with glucose, compared with palmitate, in both dietary groups. © 1970.
Description
Keywords
carbon, carbon dioxide, glucose, glycogen, lactic acid derivative, lipid, palmitic acid derivative, pyruvic acid derivative, animal, article, atherogenic diet, biomechanics, blood, coronary artery blood flow, coronary artery disease, fat intake, heart, heart muscle, male, metabolism, pathology, perfusion, physiology, rat, tissue culture, Animal, Biomechanics, Carbon Dioxide, Carbon Isotopes, Coronary Circulation, Coronary Disease, Diet, Atherogenic, Dietary Fats, Glucose, Glycogen, Heart, Lactates, Lipids, Male, Myocardium, Palmitic Acids, Perfusion, Pyruvates, Rats, Tissue Culture
Citation
Journal of Molecular and Cellular Cardiology
1
3
1
3