Animal-adapted members of the Mycobacterium tuberculosis complex endemic to the southern African subregion
Date
2016-04
Journal Title
Journal ISSN
Volume Title
Publisher
AOSIS Publishing
Abstract
Members of the Mycobacterium tuberculosis complex (MTC) cause tuberculosis (TB) in both
animals and humans. In this article, three animal-adapted MTC strains that are endemic to the
southern African subregion – that is, Mycobacterium suricattae, Mycobacterium mungi, and the
dassie bacillus – are reviewed with a focus on clinical and pathological presentations, geographic
distribution, genotyping methods, diagnostic tools and evolution. Moreover, factors influencing
the transmission and establishment of TB pathogens in novel host populations, including
ecological, immunological and genetic factors of both the host and pathogen, are discussed. The
risks associated with these infections are currently unknown and further studies will be required
for greater understanding of this disease in the context of the southern African ecosystem.
Description
CITATION: Clarke, C., Van Helden, P., Miller, M. & Parsons, S. 2016. Animal-adapted members of the Mycobacterium tuberculosis complex endemic to the southern African subregion. Journal of the South African Veterinary Association, 87(1), a1322, doi:10.4102/jsava.v87i1.1322.
The original publication is available at http://www.jsava.co.za
The original publication is available at http://www.jsava.co.za
Keywords
Natural immunity, Mycobacterium bovis, Mycobacterium tuberculosis -- Southern African subregion, Phylogeny, Mycobacterial diseases
Citation
Clarke, C., Van Helden, P., Miller, M. & Parsons, S. 2016. Animal-adapted members of the Mycobacterium tuberculosis complex endemic to the southern African subregion. Journal of the South African Veterinary Association, 87(1), a1322, doi:10.4102/jsava.v87i1.1322.