Mycobacterium tuberculosis pncA polymorphisms that do not confer pyrazinamide resistance at a breakpoint concentration of 100 micrograms per milliliter in MGIT

Whitfield, Michael G. ; Warren, Robin M. ; Streicher, Elizabeth M. ; Sampson, Samantha L. ; Sirgel, Frik A. ; Van Helden, Paul D. ; Mercante, Alexandra ; Willby, Melisa ; Hughes, Kelsey ; Birkness, Kris ; Morlock, Glenm ; Van Rie, Annelies ; Posey, James E. (2015)

CITATION: Whitfield, M. G. et al. 2015. Mycobacterium tuberculosis pncA polymorphisms that do not confer pyrazinamide resistance at a breakpoint concentration of 100 micrograms per milliliter in MGIT. Journal of Clinical Microbiology, 53:3633–3635, doi:10.1128/JCM.01001-15.

The original publication is available at http://jcm.asm.org

Article

Sequencing of the Mycobacterium tuberculosis pncA gene allows for pyrazinamide susceptibility testing. We summarize data on pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 μg/ml pyrazinamide in MGIT within a cohort of isolates from South Africa and the U.S. Centers for Disease Control and Prevention.

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