Biomarkers of HIV-associated cancer

dc.contributor.authorFlepisi, Brian Thabileen_ZA
dc.contributor.authorBouic, Patricken_ZA
dc.contributor.authorSissolak, Gerharden_ZA
dc.contributor.authorRosenkranz, Bernden_ZA
dc.identifier.citationFlepisi, B.T., et al. 2014. Biomarkers of HIV-associated cancer. Biomarkers in Cancer, 6: 11-20, doi: 10.4137/BIC.S15056en_ZA
dc.identifier.issn1179-299X (online)
dc.identifier.otherdoi: 10.4137/BIC.S15056
dc.descriptionCITATION: Flepisi, B.T., et al. 2014. Biomarkers of HIV-associated cancer. Biomarkers in Cancer, 6: 11-20, doi: 10.4137/BIC.S15056.en_ZA
dc.descriptionThe original publication is available at
dc.description.abstractCancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular signature, referred to as biomarkers, which are identifiable characteristics such as levels or activities of a myriad of genes, proteins, or other molecular features. Biomarkers can facilitate the molecular definition of cancer, provide information about the course of cancer, and predict response to chemotherapy. They offer the hope of early detection as well as tracking disease progression and recurrence. Current progress in the characterization of molecular genetics of HIV-associated cancers may form the basis for improved patient stratification and future targeted or individualized therapies. Biomarker use for cancer staging and personalization of therapy at the time of diagnosis could improve patient care. This review focuses on the relevance of biomarkers in the most common HIV-associated malignancies, namely, Kaposi sarcoma, non-Hodgkin’s lymphoma, and invasive cervical cancer.en_ZA
dc.format.extent10 pages
dc.publisherLibertas Academicaen_ZA
dc.subjectHIV infections -- Complicationsen_ZA
dc.subjectNon-Hodgkin’s lymphomaen_ZA
dc.subjectKaposi sarcomaen_ZA
dc.subjectCervix uteri -- Canceren_ZA
dc.subjectBiochemical markersen_ZA
dc.titleBiomarkers of HIV-associated canceren_ZA
dc.description.versionPublisher's versionen_ZA
dc.rights.holderAuthors retain copyrighten_ZA

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