Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors

Chakravorty, Santanu ; Klein, Hanna F. ; Hodson, Luke E. ; Rabillier, Matthias ; Fang, Zhizhou ; Richters, Andre ; Pelly, Stephen C. ; Rauh, Daniel ; Van Otterlo, Willem A. L. (2014-03)

Please cite as follows: Chakravorty, S. et al. 2014. Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors. South African Journal of Chemistry, 67:71–79.

The original publication is available at http://www.journals.co.za/sajchem

Article

Substituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamidepiperazine compounds were subsequently tested against a panel of kinases including EGFR, Abl, Akt and Aurora B.

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