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Recommendations for the management of sickle cell disease in South Africa

dc.contributor.authorAlli, N. A.en_ZA
dc.contributor.authorPatel, M.en_ZA
dc.contributor.authorAlli, H. D.en_ZA
dc.contributor.authorBassa, F.en_ZA
dc.contributor.authorCoetzee, M. J.en_ZA
dc.contributor.authorDavidson, A.en_ZA
dc.contributor.authorEssop, M. R.en_ZA
dc.contributor.authorLakha, A.en_ZA
dc.contributor.authorLouw, V. J.en_ZA
dc.contributor.authorNovitzky, N.en_ZA
dc.contributor.authorPhilip, V.en_ZA
dc.contributor.authorPoole, J. E.en_ZA
dc.contributor.authorWainwright, R.en_ZA
dc.date.accessioned2016-01-12T07:24:25Z
dc.date.available2016-01-12T07:24:25Z
dc.date.issued2014-11
dc.identifier.citationAlli, N. A. et al. 2014. Recommendations for the management of sickle cell disease in South Africa. South African Medical Journal, 104(11):743-751, doi:10.7196/SAMJ.8470.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.otherdoi:10.7196/SAMJ.8470
dc.identifier.urihttp://hdl.handle.net/10019.1/98150
dc.descriptionCITATION: Alli, N. A. et al. 2014. Recommendations for the management of sickle cell disease in South Africa. South African Medical Journal, 104(11):743-751, doi:10.7196/SAMJ.8470.en_ZA
dc.descriptionThe original publication is available at http://samj.org.za
dc.description.abstractThe spectrum of sickle cell disease (SCD) encompasses a heterogeneous group of disorders that include: (i) homozygous SCD (HbSS), also referred to as sickle cell anaemia; (ii) heterozygous SCD (HbAS), also referred to as sickle cell trait; and (iii) compound heterozygous states such as HbSC disease, HbSβ thalassaemia, etc. Homozygous or compound heterozygous SCD patients manifest with clinical disease of varying severity that is influenced by biological and environmental factors, whereas subjects with sickle cell trait are largely asymptomatic. SCD is characterised by vaso-occlusive episodes that result in tissue ischaemia and pain in the affected region. Repeated infarctive episodes cause organ damage and may eventually lead to organ failure. For effective management, regular follow-up with support from a multidisciplinary healthcare team is necessary. The chronic nature of the disease, the steady increase in patient numbers, and relapsing acute episodes have cost implications that are likely to impact on provincial and national health budgets. Limited resources mandate local management protocols for the purposes of consistency and standardisation, which could also facilitate sharing of resources between centres for maximal utility. These recommendations have been developed for the South African setting, and it is intended to update them regularly to meet new demands and challenges.en_ZA
dc.description.urihttp://samj.org.za/index.php/samj/article/view/8470
dc.format.extent9 pages
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Group
dc.subjectSickle cell anemia -- South Africaen_ZA
dc.titleRecommendations for the management of sickle cell disease in South Africaen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderSouth African Medical Journal


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