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Distinct gender differences in anthropometric profiles of a peri-urban South African HIV population : a cross sectional study

dc.contributor.authorNell, Theodore A.en_ZA
dc.contributor.authorKruger, Maritza J.en_ZA
dc.contributor.authorBeukes, Dillan C.en_ZA
dc.contributor.authorCalitz, Esmeen_ZA
dc.contributor.authorEssop, Rehanaen_ZA
dc.contributor.authorEssop, M. Faadielen_ZA
dc.contributor.otherPhysiological Sciencesen_ZA
dc.date.accessioned2015-09-02T11:39:09Z
dc.date.available2015-09-02T11:39:09Z
dc.date.issued2015-02
dc.identifier.citationNell, T. A. et al. 2015. Distinct gender differences in anthropometric profiles of a peri-urban South African HIV population: A cross sectional study. BMC Infectious Diseases, 15(85):85, doi:10.1186/s12879-015-0836-9.en_ZA
dc.identifier.issn1471-2334 (online)
dc.identifier.issn1471-2334 (print)
dc.identifier.otherdoi:10.1186/s12879-015-0836-9
dc.identifier.urihttp://hdl.handle.net/10019.1/97479
dc.descriptionCITATION: Nell, T. A. et al. 2015. Distinct gender differences in anthropometric profiles of a peri-urban South African HIV population: A cross sectional study. BMC Infectious Diseases, 15(85):85, doi:10.1186/s12879-015-0836-9.en_ZA
dc.descriptionThe original publication is available at http://bmcinfectdis.biomedcentral.com/en_ZA
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.
dc.description.abstractBackground: Highly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIV-positive individuals. Since there are concerns regarding HAART-mediated onset of cardio-metabolic diseases in the long-term, we evaluated the anthropometric profile of black HIV-infected individuals in a peri-urban setting (Western Cape, South Africa). Methods: A cross sectional study design was followed to describe the gender differences in different HAART treatment groups. HIV-positive patients (n = 44 males, n = 102 females; 20–40 years) were recruited for three groups: 1) control (HIV-positive, HAART-naïve), 2) HIV-positive (<3 years HAART), and 3) HIV-positive (>3 years HAART). Results: All participants underwent comprehensive anthropometric and bio-electrical impedance analyses. No significant differences were observed in the male treatment groups. HAART-naïve females are mostly overweight (73.90 ± 2.79). This is followed by a period of muscle wasting seen in the triceps skinfold (29.30 ± 2.19 vs 20.63 ± 1.83; p < 0.01), muscle mass (22.23 ± 0.46 vs 19.82 ± 0.54; p < 0.01), and fat free mass (49.40 ± 1.08 vs 44.16 ± 1.21; p < 0.01) upon HAART initiation (<3 years HAART). Thereafter all parameters measured had levels similar to that seen for the female HAART-naïve group. Females on <3 years HAART exhibited significantly decreased body cell mass (p < 0.01), protein mass (p < 0.01), muscle mass (p < 0.01), fat free mass (p < 0.01), and fat mass (p < 0.001) versus matched HAART-naïve controls. The W:H ratio for the female treatment groups placed the females overall at a higher risk for developing cardiovascular disease compared to the males. Conclusions: This study found striking gender-based anthropometric differences in black South African HIV-positive individuals on HAART. We also conclude from this observational study that no significant differences were found in the different male treatment groups. All female body composition parameters initially showed lower values (<3 years HAART). The female treatment group (>3 years HAART) displayed values similar to that seen in the HAART-naïve group. Higher W:H ratios in females receiving longer-term HAART potentially increases their risk for the future onset of cardio-metabolic complications.en_ZA
dc.description.urihttp://www.biomedcentral.com/content/pdf/s12879-015-0836-9.pdfen_ZA
dc.publisherBioMed Centralen_ZA
dc.subjectHIVen_ZA
dc.subjectAnthropometryen_ZA
dc.subjectBody compositionen_ZA
dc.subjectHAARTen_ZA
dc.subjectPeri-urbanen_ZA
dc.titleDistinct gender differences in anthropometric profiles of a peri-urban South African HIV population : a cross sectional studyen_ZA
dc.typeArticleen_ZA
dc.description.versionPublishers Versionen_ZA
dc.rights.holderNell et al.; licensee BioMed Centralen_ZA


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