Respiratory control of metabolism and gene expression: A common factor in obesity and cancer
The role of oxygen deficiency, or hypoxia, in carcinogenesis is being re-discovered. This 'primitive hormone' is now known to play a vital role in gene transcription and angiogenesis. One of the most recent and promising innovations in the treatment of cancer is the hypoxia-activated triazine drugs. These drugs target hypoxic cells in solid tumours, and may prove useful in the treatment of other hyperplastic diseases.