Regulatory T-cells and high levels of FOXP3 mRNA leads to decreased immune responses in HIV-TB co-infection
Poster presented at the AIDS Vaccine 2009 Conference, Paris, France 19-22 October 2009
Please cite as follows:
Loxton, A., Roberts, T., Black, G. & Walzl, G. 2009. Regulatory T-cells and high levels of FOXP3 mRNA leads to decreased immune responses in HIV-TB co-infection. Retrovirology, 6(Suppl 3):P230, doi:10.1186/1742-4690-6-S3-P230.
The original publication is available at http://www.retrovirology.com/content/6/S3/P230
Background Tuberculosis causes 2 million deaths per year and is the most important opportunistic infection in patients infected with HIV. During the co-infection of HIV/TB, natural regulatory T cells (CD4+ FOXP3+) down regulate Th1/Th2 responses. Our study analysed the regulatory Tcell phenotypes amongst participants dually infected with HIV/TB, HIV or TB alone and healthy HIV negative controls and used it as the basis for analysing anti-TB responses and gene expression in HIV infected participants.