Now showing items 1-6 of 6
Synthesis and evaluation of pantothenic acid analogues as potential inhibitors of malaria parasites and bacteria
(Stellenbosch : Stellenbosch University, 2011-12)
ENGLISH ABSTRACT: A lot of progress has been made in the development and utilization of antimalarial and antibacterial drugs. However, reports of increasing resistance to these antimicrobial agents are threatening to reduce ...
2015-12-31 Cloning and functional characterization of thiol disulfide interchange system proteins from Staphylococcus aureus
(Stellenbosch : Stellenbosch University, 2013-11-19)
ENGLISH ABSTRACT: The 21st century has seen the re-emergence of infectious diseases thought previously conquered by antibiotics. The human pathogen, Staphylococcus aureus, is one such example, with global reports listing ...
Development of an oral vaccine against the ostrich-specific mycoplasma, Mycoplasma struthionis
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: The ostrich-specific mycoplasmas Mycoplasma struthionis, Ms02 and Mycoplasma nasistruthionis, are associated with respiratory disease in ostriches, which is threatening the South African ostrich industry. ...
2015-12-31 Preliminary investigations into the use of DNA vaccines to elicit protective immune responses against the ostrich mycoplasma Ms01
(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: Mycoplasmas are evolutionarily advanced prokaryotes which have acquired the elite status of “next generation” bacterial pathogens and necessitate new paradigms in completely understanding their ...
Coenzyme a biosynthesis and utilization in Plasmodium falciparum : drug targets for antimalarial chemotherapy
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Pantothenate (also known as Vitamin B5) is the sole precursor of the essential enzyme cofactor coenzyme A (CoA) that is required in several metabolic reactions virtually in all living organisms including ...
Biocatalytic preparation and characterization of alternative substrate of MshB, a mycothiol pathway enzyme
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, utilizes mycothiol (MSH) as the major low molecular weight thiol to protect itself against oxidative stress and thereby ...