Effects of puff adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon

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dc.contributor.author Brink, S.
dc.contributor.author Steytler, J. G.
dc.date.accessioned 2011-03-18T14:59:58Z
dc.date.available 2011-03-18T14:59:58Z
dc.date.issued 1974
dc.identifier.citation Brink, S. & Steytler, J.G. 1974, Effects of puff adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon, SA Medical Journal, 47(28), 1205-1213, http://archive.samj.org.za/
dc.identifier.issn 0256-9574 (print)
dc.identifier.issn 2078-5135 (online)
dc.identifier.uri http://hdl.handle.net/10019.1/8167
dc.description The original version is available at http://www.samj.org.za/
dc.description Bibliography
dc.description.abstract The in vitro and in vivo hematological effects of puff adder (Bitis arietans) venom in the baboon (Papio ursinus) with regard to its effect on coagulation, fibrinolysis and platelet aggregation were studied. There is a delay in the intrinsic coagulation mechanism with fibrinolysis and in vitro fibrinogenolysis. Normal human platelets demonstrated an extreme susceptibility to puff adder venom in vitro. The aggregation of platelets with small dosages of venom was irreversible. The effect is related to the dosage, and appears to be the result of multiple enzyme activities, some of which are heat labile. In minimal amounts there is evidence of consumption of blood coagulation factors with sustained thrombocytopenia, but no fibrinolysis, where heparin therapy might have a beneficial effect. With larger dosages of venom the thrombocytopenia, hemorrhagic effects and shock are not prevented or corrected by heparin and heparinisation might even be harmful. The effect of heparin should be further investigated, since it might have a place in mildly affected cases of snakebite, where absorption into the blood has been slow or intermittent. It might be indicated when antivenene is not available or when patients are sensitive to serum.
dc.format.extent 8 p. : ill.
dc.language.iso en_ZA
dc.publisher Health and Medical Publishing Group (HMPG)
dc.subject Heparin; snake venom; fibrinogen; venom; bleeding; blood clotting; fibrinogenolysis; fibrinolysis; hematology; monkey; shock; theoretical study; thrombocyte aggregation; thrombocytopenia; animal; article; baboon; blood clotting test; drug effect; female; Haplorhini; male; protein denaturation; septic shock; snake; thrombocyte adhesiveness; Animal; Blood Coagulation; Blood Coagulation Tests; Female; Fibrinogen; Fibrinolysis; Haplorhini; Hemorrhage; Heparin; Male; Papio; Platelet Adhesiveness; Protein Denaturation; Shock, Septic; Snakes; Thrombocytopenia; Venoms
dc.subject Animal experimentation en_ZA
dc.subject Medical experimentation on laboratory animals en_ZA
dc.subject Poisonous snakes -- Effect of venom on -- Coagulation en_za
dc.subject Heparin therapy en_ZA
dc.subject Blood-clotting en_ZA
dc.subject Fibrinogenolysis en_ZA
dc.subject Fibrinolysis en_ZA
dc.subject Septic shock en_ZA
dc.title Effects of puff adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon
dc.type Article
dc.description.version Publishers'Version
dc.rights.holder Health and Medical Publishing Group (HMPG)
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