Mielopoiese : 'n kinetiese benadering
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The mechanisms of hemopoietic cellular proliferation are more clearly understood when the granulocytic, monocytic and macrophagic elements of the bone marrow are studied by means of in vitro cultures. Better physiological insight into stimulating and inhibitory factors is obtained in this way. These studies are of diagnostic, therapeutic and prognostic importance in the clinical handling of myeloid leukemia and neutropenia. It can be accepted today that the concept of myeloid leukemia as a neoplastic process with an increased production of autonomous cell populations is to a large extent outdated, and these cells can be induced in vitro to differentiate into mature polymorphs. In the past it has been demonstrated that in vitro successes are followed by in vivo results, and in particular it is hoped that with the development of techniques for concentration of colony stimulating factor, that this might be of therapeutic advantage in selected leukemia patients in the future.