Lysosomal disruption during the development of endotoxic shock in the baboon

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dc.contributor.author Janson, P. M. C.
dc.contributor.author Kuhn, S. H.
dc.contributor.author Geldenhuys, J. J.
dc.date.accessioned 2011-03-18T14:59:57Z
dc.date.available 2011-03-18T14:59:57Z
dc.date.issued 1975-06
dc.identifier.citation Janson, P.M.C., Kuhn, S.H. & Geldenhuys, J.J. 197. Lysosomal disruption during the development of endotoxic shock in the baboon. SA Medical Journal, 49(26), 1041-1047, http://archive.samj.org.za/
dc.identifier.issn 0256-9574 (print)
dc.identifier.issn 2078-5135 (online)
dc.identifier.uri http://hdl.handle.net/10019.1/8158
dc.description The original version is available at http://www.samj.org.za/
dc.description.abstract Lysosomal disruption with release of lysosomal enzymes has been described in shock. This study was designed to demonstrate the release of lysosomal enzymes in the liver and lung in addition to determining circulating serum lysosomal enzyme values. Therapeutic means of reducing or inhibiting lysosomal disruption were also investigated. Five groups of baboons were investigated: Group A: (control group) - no endotoxin or treatment administered. Group B: (endotoxin only) - liver and lung tissues showed an increase in free lysosomal enzymes, and a similar increase in circulating serum lysosomal enzymes was demonstrated. Group C: (chloroquine treatment (lysosomal stabiliser) following endotoxin administration) - the liver and lung tissues showed a smaller increase in free lysosomal enzymes and a corresponding lesser increase in circulating serum lysosomal enzymes was demonstrated. Group D: (dexamethasone treatment (lysosomal membrane stabiliser) following endotoxin administration) - the rise in lysosomal tissue and serum enzyme values was less than that in group B. Group E: (combination of chloroquine and dexamethasone treatment following endotoxin administration) - the rise in lysosomal tissue and serum values was less than that demonstrated in group B. The survival of the animals in the various groups correlated well with the lysosomal enzyme tissue and serum values, as did the monitored haemodynamic, haematological and other parameters. en_ZA
dc.format.extent p. 1041-1047 : ill.
dc.language.iso en_ZA
dc.publisher Health and Medical Publishing Group (HMPG)
dc.subject Lysosome enzymes en_ZA
dc.subject Endotoxic shock en_ZA
dc.title Lysosomal disruption during the development of endotoxic shock in the baboon en_ZA
dc.type Article
dc.description.version Publishers' Version
dc.rights.holder Health and Medical Publishing Group (HMPG)


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