Morphological changes during experimentally induced hypercholesterolemia [MORFOLOGIESE VERANDERINGE TYDENS EKSPERIMENTELE HIPERCHOLESTEROLEMIE]

Rossouw D.J. ; Engelbrecht F.M. (1973)


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The morphological changes in various organs and tissues from rabbits with experimentally induced hypercholesterolemia were investigated. The outstanding histopathologic feature was the presence of atheromatous lesions in the aorta, pulmonary and intramural coronary vessels. In spite of the pronounced involvement of the subendocardial vessels, manifestations of ischemia and myocardial infarction could be demonstrated in only a limited number of animals. The presence of foam cells in the lung parenchyma imply that the lung has a more important role in handling abnormal cholesterol loads than has hitherto been anticipated. Hypercholesterolemia was also associated with marked adrenal hypertrophy. The infiltration of mononuclear cells, which was observed, could have had an effect on atherogenesis through its influence on the function of this gland. The zonal delimitation of the foam cells and lipoid infiltration in the peritubular spaces at the corticomedullary junction in the kidney, raise some interesting questions about the nature and function of the interstitial cells of the renomedullary region. Foam cells were also found to accumulate in the spleen and lymph glands. This may affect the function of these structures to such an extent that it could possibly enhance the histopathologic, biochemical and hematologic changes during hypercholesterolemia.

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