Disseminated tuberculosis, bone marrow necrosis and lymphoma : a case report

Staples, W. G. ; Getaz, E. P. ; Botha, D. (1977)

CITATION: Staples, W. G., Getaz, E. P. & Botha, D. 1977. Disseminated tuberculosis, bone marrow necrosis and lymphoma : a case report. South African Medical Journal, 52(17):680-683.

The original publication is available at http://www.samj.org.za

Article

Tuberculosis often complicates lymphoma, and bone marrow necrosis has been described in disseminated tuberculosis. However, the association of lymphoma, disseminated tuberculosis and bone marrow necrosis is rare. We report a patient with this triple association. After a 3-week influenza-like illness the patient was admitted to hospital semicomatose with pancytopenia and hyponatraemia. During routine examination a bone marrow trephine biopsy revealed diffuse lymphomatous infiltration with scattered necrotic foci. On Ziehl-Neelsen staining these foci exhibited numerous acid-fast bacilli. The patient subsequently died and at autopsy was found to have widely disseminated non-reactive tuberculosis.

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