Lymphomas of large cells
The original publication is available at http://www.samj.org.za
Historical aspects of the classification of large-cell lymphomas are described. Immunological characterization of the lymphomas is possible by identification of T and B lymphocytes according to their cell membrane surface characteristics. The pathogenesis of lymphomas has been clarified by the germinal (follicular) center cell concepts of Lennert and Lukes and Collins. The various classifications are presented and compared. Whether these subdivisions will have any relevance in the clinical context remains to be seen.
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