Mitochondrial function and free fatty acid levels in rats with portacaval shunt

Lochner, A. ; Benade, A. J. S. ; Kotze, J. C. N. (1979)

CITATION: Lochner, A., Benade, A. J. S. & Kotze, J. C. N. 1979. Mitochondrial function and free fatty acid levels in rats with portacaval shunt. South African Medical Journal, 56:181-186.

The original publication is available at http://www.samj.org.za

Article

The effects of portacaval shunting on the oxidative phosphorylation process of mitochondria isolated from rat liver and skeletal muscle were evaluated and correlated with mitochondrial free fatty acid (FFA) contents. ADP/O ratios, respiratory control index and Q02 values were significantly depressed in liver mitochondria from portacaval- shunted rats; these changes were associated with decreased mitochondrial FFA contents. The mitochondrial function of skeletal muscle was unaltered.

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