Administration of depolarizing muscle relaxants after non-depolarizer reversal: when is it safe?
CITATION: De Roubaix, J.A.M. 1982. Administration of depolarizing muscle relaxants after non-depolarizer reversal: when is it safe? . S Afr Med J, 71(4):583-584.
The original publication is available at http://www.samj.org.za
ENGLISH ABSTRACT: In the light of studies on the duration of action and pharmacokinetics of intravenous neostigmine, it is recommended that, depending upon the dosage administered, at least 1 hour should elapse before a depolarizer can safely be given after neuromuscular reversal with neostigmine, and at least 90-120 minutes after reversal with physostigmine. It is suggested that a diluted test dose of depolarizer be given first, and its effect monitored with a peripheral nerve stimulator because fasciculations will not occur.