Low plasma pyridoxal-5'-phosphate levels in children with the nephrotic syndrome
CITATION: Van Buuren, A. J., Shephard, G. S. & Labadarios, D. 1985. Low plasma pyridoxal-5'-phosphate levels in children with the nephrotic syndrome. South African Medical Journal, 61:329-332.
The original publication is available at http://www.samj.org.za
Of 35 children with the nephrotic syndrome in relapse, 88% were found to have low circulating plasma pyridoxal-5'-phosphate (PLP) levels. Remission of the syndrome was associated with spontaneous normalization of plasma PLP levels in 23 such children. A significant (P < 0.001) positive correlation (r = 0.81) was found between plasma albumin and PLP levels and a significant (P < 0.001) negative correlation (r = -0.66) between plasma PLP and serum cholesterol levels. The low plasma PLP levels may be due to enhanced urinary excretion of albumin-bound PLP in view of the severe proteinuria which characterizes the nephrotic syndrome.