Low plasma pyridoxal-5'-phosphate levels in children with the nephrotic syndrome

Van Buuren A.J. ; Shephard G.S. ; Labadarios D. (1985)


The original publication is available at http://www.samj.org.za


Of 35 children with the nephrotic syndrome in relapse, 88% were found to have low circulating plasma pyridoxal-5'-phosphate (PLP) levels. Remission of the syndrome was associated with spontaneous normalization of plasma PLP levels in 23 such children. A significant (P < 0.001) positive correlation (r = 0.81) was found between plasma albumin and PLP levels and a significant (P < 0.001) negative correlation (r = -0.66) between plasma PLP and serum cholesterol levels. The low plasma PLP levels may be due to enhanced urinary excretion of albumin-bound PLP in view of the severe proteinuria which characterizes the nephrotic syndrome.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/7525
This item appears in the following collections: