The β-adrenoceptor and endocrine abnormalities in juvenile depression

Carstens M.E. ; Taljaard J.J.F. ; Van Zyl A.M. (1990)


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Neuro-endocrine disturbances were determined in juvenile depressives and possible correlations with biochemical abnormalities investigated. It was established that, as in adult depressives, the young also showed a high incidence of cortisol non-suppression after dexamethasone administration. In addition, a positive correlation observed between lymphocyte β-adrenoceptor maximal number of binding sites and basal cortisol levels stresses the involvement of the noradrenergic neurotransmission system.

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