Permeability of intestinal mucosa to crystalline and tabletted isoniazid (INH)
CITATION: Van der Bijl, P., Seifart, H. I. & Van Eyk, A. D. 2003. Permeability of intestinal mucosa to crystalline and tabletted isoniazid (INH). South African Medical Journal, 93(2):127-128.
The original publication is available at http://www.samj.org.za
When administered orally, isoniazid (INH), which continues to form the basis of most first-line standard antituberculosis regimens, reaches peak plasma concentrations of 3 - 5 μg/ml within 1 - 2 hours after ingestion of usual doses.1 Various tablet and slow-release matrix forms are available and these processed preparations are most often used clinically. However, various studies undertaken in our Department have shown crystalline INH to produce better blood levels within the first 2 hours after ingestion than the commonly used tabletted form.