• Adenocarcinoma the most common cell type in patients presenting with primary lung cancer in the Western Cape 

      Koegelenberg, Coenraad F. N.; Aubeelack, Kushroo; Nanguzgambo, Aldoph B.; Irusen, Elvis M.; Mowlana, Abdurasiet; Von Groote-Bidlingmaier, Florian; Bolliger, Chris T. (Health and Medical Publishing Group (HMPG), 2011-05)
      Lung cancer is the most common cause of cancer-related mortality worldwide for men and women, causing approximately 1.2 million deaths per year. The absolute and relative frequencies of lung cancer have risen dramatically ...
    • Asthma control 

      Irusen, E. M. (Continuing Medical Education, 2008-04)
      The SA Thoracic Society and the Global Initiative for Asthma (GINA) have recently published updated guidelines to assist practitioners in the management of asthma. The guidelines were based on reports that asthma ...
    • Chronic obstructive pulmonary disease in South Africa : under-recognised and undertreated 

      Allwood, Brian W.; Van Zyl-Smit, Richard N. (Health & Medical Publishing Group, 2015)
      Chronic obstructive pulmonary disease (COPD) is a common, preventable but incurable condition currently ranked third in global mortality estimates. Worldwide, 65 million people are estimated to have moderate to severe ...
    • Community-acquired pneumonia - factors influencing intensive care admission 

      Van Eeden, S. F.; Coetzee, A. R.; Joubert, J. R. (Health & Medical Publishing Group, 1988-01)
      The mortality rate in critically ill patients with pneumonia who receive invasive vital organ support, including mechanical ventilation, in an intensive care unit (ICU) remains above 50%. The contribution of these costly ...
    • Complete resolution of apparently definite radiological and histological usual interstitial pneumonia 

      Simon, D.; Irusen, E. M.; Allwood, Brian W.; Rigby, J.; Koegelenberg, C. F. N. (Health & Medical Publishing Group, 2018-08-30)
      ENGLISH ABSTRACT: Idiopathic pulmonary fibrosis is considered to be the most common form of pulmonary fibrosis. It is a progressive and irreversible disease with a reported median survival of ~3 years. The pathological ...
    • Contemporary best practice in the management of malignant pleural effusion 

      Koegelenberg, Coenraad F. N.; Shaw, Jane A.; Irusen, Elvis M.; Lee, Y. C. Gary (SAGE Publications, 2018)
      ENGLISH ABSTRACT: Malignant pleural effusion (MPE) affects more than 1 million people globally. There is a dearth of evidence on the therapeutic approach to MPE, and not surprisingly a high degree of variability in the ...
    • COVID-19 in Africa : care and protection for frontline healthcare workers 

      Chersich, Matthew F.; Gray, Glenda; Fairlie, Lee; Eichbaum, Quentin; Mayhew, Susannah; Allwood, Brian W.; English, Rene; Scorgie, Fiona; Luchters, Stanley; Simpson, Greg; Mosalman Haghighi, Marjan; Duc Pham, Minh; Rees, Helen (BioMed Central, 2020)
      Medical staff caring for COVID-19 patients face mental stress, physical exhaustion, separation from families, stigma, and the pain of losing patients and colleagues. Many of them have acquired SARS-CoV-2 and some have ...
    • The current aetiology of malignant pleural effusion in the Western Cape Province, South Africa 

      Koegelenberg, C. F. N.; Bennji, S. M.; Boer, E.; Schubert, P. T.; Shaw, J. A.; Allwood, Brian W.; Irusen, E. M. (Health & Medical Publishing Group, 2018-04)
      Background: Malignant pleural effusion (MPE) represents a very common cause of pleural exudates, and is one of the most challenging pleural disorders to manage. This could be attributed to the paucity of high-quality ...
    • The diagnostic accuracy of integrated positron emission tomography/computed tomography in the evaluation of pulmonary mass lesions in a tuberculosis-endemic area 

      Du Toit, R.; Shaw, J. A.; Irusen, E. M.; Von Groote-Bidlingmaier, F.; Warwick, J. M.; Koegelenberg, C. F. N. (Health and Medical Publishing Group, 2015)
      Background. Integrated positron emission tomography/computed tomography (PET-CT) is a well-validated modality for assessing pulmonary mass lesions and specifically for estimating risk of malignancy. Tuberculosis (TB) ...
    • Does access to private healthcare influence potential lung cancer cure rates? 

      John, Thadathilankal-Jess; Plekker, Dante; Irusen, Elvis M.; Koegelenberg, Coenie F. N. (Health and Medical Publishing Group, 2017)
      Background. Numerous studies show a link between poor socioeconomic status (SES) and late-stage cancer diagnosis. However, this has not been consistently shown looking at non-small-cell lung cancer (NSCLC) in isolation. ...
    • Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretion 

      Van Rensburg, Lyne; Van Zyl, Johann M,; Smith, Johan; Goussard, Pierre (BMC (part of Springer Nature), 2019-12-05)
      Background: Bronchoalveolar lavage is a useful bronchoscopy technique. However, studies in “normal” children populations are few. Furthermore, the anti-inflammatory effects of exogenous pulmonary surfactants on ...
    • Endoscopic lung volume reduction in severe emphysema 

      Koegelenberg, Coenraad Frederik N.; Theron, Johan; Bruwer, J. W.; Allwood, Brian W.; Vorster, Morne J.; Von Groote-Bidlingmaier, Florian; Dheda, Keertan (Health & Medical Publishing Group, 2015)
      ENGLISH ABSTRACT: Therapeutic options in severe emphysema are limited. Endoscopic lung volume reduction (ELVR) refers to bronchoscopically inducing volume loss to improve pulmonary mechanics and compliance, thereby reducing ...
    • Fatal tumour pulmonary embolism 

      Masoud, Salim Rashid; Koegelenberg, Coenraad Frederik Nicolaas; Van Wyk, Abraham Christoffel; Allwood, Brian W. (Wiley Open Access, 2017)
      A 30-year-old female with no significant past medical history was referred to our facility with sudden onset of shortness of breath. She had a low clinical probability for pulmonary thromboembolism and a computed ...
    • Five-year follow-up of participants diagnosed with chronic airflow obstruction in a South African Burden of Obstructive Lung Disease (BOLD) survey 

      Allwood, Brian W.; Gillespie, R.; Bateman, M.; Olckers, H.; Taborda-Barata, Luis; Calligaro, G. L.; Van Zyl-Smit, R.; Cooper, C. B.; Beyers, Nulda; Bateman, E. D. (Health & Medical Publishing Group, 2018-02-01)
      Background. A community-based prevalence survey performed in two suburbs in Cape Town, South Africa (SA), in 2005, using the international Burden of Obstructive Lung Disease (BOLD) method, confirmed a prevalence of chronic ...
    • Guideline for office spirometry in adults, 2004 

      Van Schalkwyk, E. M.; Schultz, C.; Joubert, J. R.; White, N. W. (Health & Medical Publishing Group, 2004-07)
      Objective. To provide clinical guidelines for office spirometry in South Africa. Options. More stringent guidelines are required for diagnostic laboratories and research. Outcomes. To minimise variations in standard practice ...
    • Guideline for office spirometry in adults, 2012 

      Koegelenberg, Coenraad Frederik N.; Swart, Francois; Irusen, Elvis Malcolm (Health & Medical Publishing Group, 2013)
      Background. Office spirometry remains an integral part of a comprehensive respiratory evaluation and is used to categorise the nature, severity and progression of respiratory diseases and to measure response to treatment. ...
    • Iatrogenic bleeding during flexible bronchoscopy : risk factors, prophylactic measures and management 

      Bernasconi, Maurizio; Koegelenberg, Coenraad F. N.; Koutsokera, Angela; Ogna, Adam; Casutt, Alessio; Nicod, Laurent; Lovis, Alban (European Respiratory Society, 2017-03-18)
      ENGLISH ABSTRACT: Significant iatrogenic bleeding during flexible bronchoscopy is fortunately rare and usually self-limiting. Life-threatening bleeding, however, can occur, especially after conventional or cryoprobeassisted ...
    • The impact of an electronic clinical decision support for pulmonary embolism imaging on the efficiency of computed tomography pulmonary angiography utilisation in a resource-limited setting 

      Murthy, C.; Davis, R.; Koegelenberg, C. F. N.; Irusen, E. M.; Pitcher, R. D. (Health & Medical Publishing Group, 2016-01)
      ENGLISH SUMMARY : Background. Pulmonary embolism (PE) is associated with high morbidity and mortality. Effective intervention requires prompt diagnosis. Computed tomography pulmonary angiography (CTPA) is sensitive and ...
    • The impact of HIV infection on the presentation of lung cancer in South Africa 

      Koegelenberg, C. F. N.; Van Der Made, T.; Taljaard, J. J.; Irusen, E. M. (Health & Medical Publishing Group, 2016)
      ENGLISH ABSTRACT: Background. Despite the very high background prevalence of HIV and smoking-related diseases in sub-Saharan Africa, very little is known about the presentation of lung cancer in HIV-infected individuals. ...
    • Indications for the use of bronchial thermoplasty in severe asthma 

      Dheda, Keertan; Koegelenberg, Coenraad F. N.; Esmail, Aliasgar; Irusen, Elvis; Wechsler, Michael; Niven, Rob M.; Chung, Kian Fan; Bateman, Eric D. (Health & Medical Publishing Group, 2015)
      Approximately 5% of the ~3 million asthmatics in South Africa have severe asthma that is associated with substantial morbidity, cost, absenteeism, preventable mortality, and the requirement for costly chronic medication ...