Research Articles (Cardiology)
Recent Submissions
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A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
(BioScientifica, 2017)The therapeutic implications of bicuspid aortic valve associations have come under scrutiny in the transcatheter aortic valve implantation era. We evaluate the spectrum of mitral valve disease in patients with bicuspid ...
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Screening for rheumatic heart disease : is a paradigm shift required?
(BioScientifica, 2017)This focused review presents a critical appraisal of the World Heart Federation criteria for the echocardiographic diagnosis of rheumatic heart disease (RHD) and its performance in African RHD screening programmes. It ...
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Rheumatic heart disease screening : current concepts and challenges
(Medknow Publications, 2017)Rheumatic heart disease (RHD) is a disease of poverty, is almost entirely preventable, and is the most common cardiovascular disease worldwide in those under 25 years. RHD is caused by acute rheumatic fever (ARF) which ...
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An approach to the patient with a suspected tachycardia in the emergency department
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Patients present to the emergency department with either an ongoing tachycardia or a history suspicious of a tachycardia. Either way, the tachycardia needs to be documented, preferably on a 12-lead ...
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An approach to the patient with suspected pericardial disease
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Diseases of the pericardium commonly manifest in one of three ways: acute pericarditis, pericardial effusion and constrictive pericarditis. In the developed world, the most common cause of acute pericarditis ...
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The heart team, TAVI and natural selection
(South African Heart Association, 2016)ENGLISH ABSTRACT: The announcement in 2002 that Alan Cribier had performed the first Transcatheter Aortic Valve Implantation (TAVI) ranked right up there with the announcement that the first heart transplant had been ...
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Delivering cardiac care : the next frontier
(South African Heart Association, 2016)ENGLISH ABSTRACT: The 17th annual South African Heart congress, co-hosted with the annual meeting of the World Society of Cardiothoracic surgery, brings together both local and international pioneers in the field of ...
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Tri-leaflet mitral valves – when lightning strikes thrice
(South African Heart Association, 2016)ENGLISH ABSTRACT: Mitral valves are well known to be bi-leaflet structures with attachments from both leaflets (anterior and posterior) to both papillary muscles (anterolateral and posteromedial). Congenital abnormalities ...
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When opportunity knocks
(South African Heart Association, 2016)ENGLISH ABSTRACT: Constrictive pericarditis remains a common medical problem in developing countries where it frequently complicates tuberculous pericarditis. In addition, it is not infrequently seen in the developed world ...
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Cardiology training in South Africa – on the brink?
(South African Heart Association, 2016)ENGLISH ABSTRACT: More often than not, when we use the expression “on the brink”, we are referring to an impending bad situation. On the edge of a cliff without wings so to speak…, on the brink of disaster…, on the brink ...
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Redefining effusive-constrictive pericarditis with echocardiography
(Korean Society of Journal of Cardiovascular Ultrasound Office, 2016-12)Background: Effusive-constrictive pericarditis (ECP) is traditionally diagnosed by using the expensive and invasive technique of direct pressure measurements in the pericardial space and the right atrium. The aim of this ...
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Tuberculous pericarditis : challenges and controversies in the modern era
(South African Heart Association, 2016)Tuberculous pericarditis (TBP) continues to wreak havoc across Sub-Saharan Africa (SSA). Despite more than 5 decades of treatment and research into TBP, we are not much closer to alleviating the suffering and mortality ...
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Persistant left superior vena cava – the value of an agitated saline contrast study
(South African Heart Association, 2014)A persistant left superior vena cava (PLSVC) draining to the coronary sinus (CS) is the most common venous anomaly of the thorax, affecting approximately 0.5% - 2% of the general population, and is present in up to 10% of ...
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Management of aortic stenosis in pregnancy
(South African Heart Association, 2014)Aortic stenosis in pregnancy is most commonly related to congenital or bicuspid aortic stenosis, which is associated with an aortopathy and ascending aortic dilatation. The management of AS in pregnancy is based on a few ...
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Closure of pulmonary arterio-venous malformations in a patient with a novel form of Hereditary Haemorrhagic Telangiectasia
(South African Heart Association, 2014)Image in Cardiology: Hereditary Haemorrhagic Telangiectasia.
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Intervention for congenital and structural heart disease : beyond the cradle
(South African Heart Association, 2014)During the last four decades we have seen an exponential growth in interventions (both medical and invasive) to diagnose and treat adult cardiac disorders. Coronary stents are in their fourth generation and the developments ...
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Screening for asymptomatic rheumatic heart disease : understanding the mechanisms key to the diagnostic criteria
(South African Heart Association, 2015)This focussed review describes important problems experienced in the world of echocardiographic screening for asymptomatic rheumatic heart disease (RHD). It offers a critical appraisal of the screening criteria and their ...
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Post-traumatic, intrapulmonary arteriovenous fistula : diagnosis by trans-oesophageal echocardiography
(South African Heart Association, 2015)Abstract not available
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Evaluation of the SUNHEART cardiology outreach programme
(South African Heart Association, 2015)Introduction: The demand for advanced cardiac care and specialised interventions is on the increase and this results in bottlenecks and increased waiting times for patients who require advanced cardiac care. By decentralising ...
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The South African clinical trial industry : implications of problems with the issuing of human tissue export permits
(Health & Medical Publishing Group, 2013-06-21)ENGLISH ABSTRACT: The National Health Act requires a valid permit before human biological tissue samples are exported from South Africa. However, delays in issuing export permits make it difficult for many researchers and ...
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FDA abandons the declaration of Helsinki : the effect on the ethics of clinical trial conduct in South Africa and other developing countries
(Health and Medical Publishing Group (HMPG), 2012-12)Four years ago, the US Food and Drug Administration (FDA) ceased compliance with the Declaration of Helsinki (DoH) (2000 revision and all subsequent revisions) for conduct of clinical trials outside its borders. It instead ...
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Randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy
(PLoS, 2012-11-13)Objectives: Mipomersen, an antisense oligonucleotide targeting apolipoprotein B synthesis, significantly reduces LDL-C and other atherogenic lipoproteins in familial hypercholesterolemia when added to ongoing maximally ...
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First case of trans apical implantation of an aortic valve in a patient with dextrocardia
(BioMed Central, 2012-03)Abstract We describe the clinical presentation and implantation procedure of the first transcatheter aortic valve implantation described in a patient with dextrocardia.
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Computerised analysis, interpretation, storage and retrieval of electrocardiograms : a study and review of available systems
(HMPG, 1974-06)A study was undertaken to determine the feasibility of introducing a computerised electrocardiographic analysis and interpretive system as a service to a teaching and referral hospital. Available computer equipment and ...
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Pulmonary arteriovenous fistulas : a case presentation and review of the literature
(HMPG, 1980-03)A young woman had a pulmonary arteriovenous fistula localized to the right lower lobe. The presence of a patent foramen ovale (atrial septal defect) detected preoperatively allowed for a unique investigation of this case. ...
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Pseudoxanthoma elasticum with cardiac involvement : a case report and review of the literature
(HMPG, 1981-02)A young Black man with many features of pseudoxanthoma elasticum (PXE), confirmed by skin biopsy, complained of classic angina pectoris, decreasing effort tolerance, and palpitations. Clinically he was in severe congestive ...
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Iatrogenic aortocoronary vein fistula : a case presentation and review of the literature
(Health and Medical Publishing Group -- HMPG, 1982-12)A patient underwent aortocoronary saphenous bypass grafting to the left anterior descending coronary artery (LADA) and its first diagonal branch for the relief of severe angina pectoris. There was difficulty in exposure ...
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Hyperkalaemic complete heart block : a report of 2 unique cases and a review of the literature
(HMPG, 1983-03)Two White male patients with temporary complete heart block (CHB) secondary to hyperkalaemia are presented. One, a 40-year-old man, developed CHB with ensuing shock within the first 24 hours of repeat aortic valve replacement ...
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Lack of a relationship between plasma pyridoxal phosphate levels and ischaemic heart disease
(Health and Medical Publishing Group (HMPG), 1985-04)The 'vitamin B6-homocysteine theory' has been proposed as an alternative to the widely accepted lipid hypothesis in the aetiology of ischaemic heart disease (IHD). In a cross-sectional study of 71 white men with evidence ...
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Pseudo-myocardial infarction pattern after aortocoronary saphenous vein bypass graft surgery : a case report
(1986-08)In a 51-year-old medical colleague with symptomatic atherosclerotic coronary artery disease, coronary arteriography delineated significant left mainstem, left anterior descending and left circumflex coronary artery lesions ...
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