A - Reviewers

 

Recent Submissions

  • Laboratory tests in the diagnosis of cystic fibrosis 

    Hoffmann, M.; Meyer, W. P. (Health & Medical Publishing Group, 2012-07)
    Cystic fibrosis (CF) is the most common autosomal recessive disorder among white individuals, and occurs in all South African population groups. Recent evidence suggests a prevalence of 1 in 2 000 among white South Africans ...

  • Scaling Up mHealth: Where Is the Evidence? 

    Tomlinson, M.; Rotheram-Borus, M. J.; Swartz, L.; Tsai, A. C. (PLOS, 2013-02-12)
    Despite hundreds of mHealth pilot studies, there has been insufficient programmatic evidence to inform implementation and scale-up of mHealth. We discuss what constitutes appropriate research evidence to inform scale up. ...

  • Novel SNP Discovery in African Buffalo, Syncerus caffer, Using High-Throughput Sequencing 

    Le Roex, Nikki; Noyes, Harry; Brass, Andrew; Bradley, Daniel G.; Kemp, Steven J.; Kay, Suzanne; Van Helden, Paul D.; Hoal, Eileen G. (PLOSPLOS, 2012-11-07)
    The African buffalo, Syncerus caffer, is one of the most abundant and ecologically important species of megafauna in the savannah ecosystem. It is an important prey species, as well as a host for a vast array of nematodes, ...

  • Convergent Evolution Associated with Habitat Decouples Phenotype from Phylogeny in a Clade of Lizards 

    Edwards, Shelley; Vanhooydonck, Bieke; Herrel, Anthony; Measey, G. John; Tolley, Krystal A. (PLOS, 2012-12-12)
    Convergent evolution can explain similarity in morphology between species, due to selection on a fitness-enhancing phenotype in response to local environmental conditions. As selective pressures on body morphology may be ...

  • The Rate of Sputum Smear-Positive Tuberculosis after Treatment Default in a High-Burden Setting: A Retrospective Cohort Study 

    Marx, Florian M.; Dunbar, Rory; Enarson, Donald A.; Beyers, Nulda (PLOS, 2012-09-25)
    Rationale: High rates of recurrent tuberculosis after successful treatment have been reported from different high burden settings in Sub-Saharan Africa. However, little is known about the rate of smear-positive tuberculosis ...

  • Oleanolic Acid: A Novel Cardioprotective Agent That Blunts Hyperglycemia-Induced Contractile Dysfunction 

    Mapanga, Rudo F.; Rajamani, Uthra; Dlamini, Nonkululeko; Zungu-Edmondson, Makhosazane; Kelly-Laubscher, Roison; Shafiullah, Mohammed; Wahab, Athiq; Hasan, Mohamed Y.; Fahim, Mohamed A.; Rondeau, Phillipe; Bourdon, Emmanuel; Essop, M. Faadiel (PLOS, 2012-10-16)
    Diabetes constitutes a major health challenge. Since cardiovascular complications are common in diabetic patients this will further increase the overall burden of disease. Furthermore, stress-induced hyperglycemia in ...

  • Ontogeny of Toll-Like Receptor Mediated Cytokine Responses of South African Infants throughout the First Year of Life 

    Reikie, Brian A.; Adams, Rozanne C.M.; Ruck, Candice E.; Ho, Kevin; Leligdowicz, Aleksandra; Pillay, Santoshan; Naidoo, Shalena; Fortuno, Edgardo S. III; De Beer, Corena; Preiser, Wolfgang; Cotton, Mark F.; Speert, David P.; Esser, Monika; Kollmann, Tobias R. (PLOS, 2012-09-13)
    The first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased ...

  • Systematic Genetic Nomenclature for Type VII Secretion Systems 

    Bitter, Wilbert; Houben, Edith N. G.; Bottai, Darria; Brodin, Priscille; Brown, Eric J.; Cox, Jeffery S.; Derbyshire, Keith; Fortune, Sarah M.; Gao, Lian-Yong; Liu, Jun; Gey van Pittius, Nicolaas; Pym, Alexander S.; Rubin, Eric J.; Sherman, David R.; Cole, Stewart T.; Brosch, Roland (Plos, 2009)
    Mycobacteria, such as the etiological agent of human tuberculosis, Mycobacterium tuberculosis, are protected by an impermeable cell envelope composed of an inner cytoplasmic membrane, a peptidoglycan layer, an ...

  • Antiretroviral Therapy for Prevention of Tuberculosis in Adults with HIV: A Systematic Review and Meta-Analysis 

    Suthar, A. B.; Lawn, S. D.; del Amo, J; Getahun, H; Dye, C; Sculier, D; Sterling, T. R.; Chaisson, R. E.; Williams, B. G.; Harries, A. D.; Granich, R. M. (PLOS, 2012-07-24)
    Background: Human immunodeficiency virus (HIV) infection is the strongest risk factor for developing tuberculosis and has fuelled its resurgence, especially in sub-Saharan Africa. In 2010, there were an estimated 1.1 ...

  • Parameter Identifiability and Sensitivity Analysis Predict Targets for Enhancement of STAT1 Activity in Pancreatic Cancer and Stellate Cells 

    Rateitschak, Katja; Winter, Felix; Lange, Falko; Jaster, Robert; Wolkenhauer, Olaf (PLoS, 2012-12-20)
    The present work exemplifies how parameter identifiability analysis can be used to gain insights into differences in experimental systems and how uncertainty in parameter estimates can be handled. The case study, presented ...

  • Randomized, Placebo-Controlled Trial of Mipomersen in Patients with Severe Hypercholesterolemia Receiving Maximally Tolerated Lipid-Lowering Therapy 

    McGowan, M. P.; Tardif, J. C.; Ceska, R; Burgess, L. J.; Soran, H; Gouni-Berthold, I; Wagener, G; Chasan-Taber, S (PLOS, 2012-11-13)
    Objectives: Mipomersen, an antisense oligonucleotide targeting apolipoprotein B synthesis, significantly reduces LDL-C and other atherogenic lipoproteins in familial hypercholesterolemia when added to ongoing maximally ...

  • Extinction Risk and Diversification Are Linked in a Plant Biodiversity Hotspot 

    Davies, T. Jonathan; Smith, Gideon F.; Bellstedt, Dirk U.; Boatwright, James S.; Bytebier, Benny; Cowling, Richard M.; Forest, Felix; Harmon, Luke J.; Muasya, A. Muthama; Schrire, Brian D.; Steenkamp, Yolande; van der Bank, Michelle; Savolainen, Vincent (PLoS, 2011-05)
    It is widely recognized that we are entering an extinction event on a scale approaching the mass extinctions seen in the fossil record. Present-day rates of extinction are estimated to be several orders of magnitude greater ...

  • Non-Communicable Diseases in Sub-Saharan Africa: The Case for Cohort Studies 

    Holmes, M.D.; Dalal, S.; Volmink, J.; Adebamowo, C.A.; Njelekela, M.; Fawzi, W. W.; Willett, W. C.; Adami, H. (PLOS, 2010-05-11)
    We believe there is an urgent need for longitudinal cohorts based in sub-Saharan Africa (SSA). This conclusion is drawn from the fact that non-communicable diseases (NCDs) cause a large and growing disease burden (please ...

  • Hemispheric Asymmetries in Biodiversity—A Serious Matter for Ecology 

    Chown, Steven L.; Sinclair, Brent J.; Leinaas, Hans P.; Gaston, Kevin J. (PLOS, 2004-11)
    Penguins have been receiving a lot of bad press lately. They are considered somehow counter, spare, strange. Unlike most plant and animal groups, they do not show a peak of species richness towards the equator and a ...

  • Gender Differences in Survival among Adult Patients Starting Antiretroviral Therapy in South Africa: A Multicentre Cohort Study 

    Cornell, M.; Schomaker, M.; Garone, D. B.; Giddy, J.; Hoffmann, C. J.; Lessells, R.; Maskew, M.; Prozesky, H.; Wood, R.; Johnson, L. F.; Egger, M.; Boulle, A.; Myer, L. (PLOS, 2012-09-04)
    Background: Increased mortality among men on antiretroviral therapy (ART) has been documented but remains poorly understood. We examined the magnitude of and risk factors for gender differences in mortality on ART. ...

  • Mutlidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients 

    Ahuja, S. D.; Ashkin, D.; Avendano, M.; Banerjee, R.; Bauer, M.; Bayona, J. N.; Becerra, M. C.; Benedetti, A.; Burgos, M.; Centis, R.; Chan, E. D.; Chen-Yuan, C.; Cox, H.; D'Ambrosio, L.; DeRiemer, K.; Dung, N. H.; Enarson, D.; Falzon, D.; Flanagan, K.; Flood, J.; Garcia-Garcia, M. L.; Ghandi, N.; Granich, R. M.; Hollm-Delgado, M. G.; Holtz, T. H.; Iseman, M. D.; Jarlsberg, L. G.; Keshavjee, S.; Kim, H.; Koh, W.; Lancaster, J.; Lange, C.; De Lange, W. C. M.; Leimane, V.; Leung, C. C.; Li, J.; Menzies, D.; Migliori, G. B.; Mishustin, S. P.; Mitnick, C.D.; Narita, M.; O'Riordan, P.; Pai, M.; Palmero, D.; Park, S.; Pasvol, G.; Pena, J.; Perez-Guzman, C.; Quelapio, M. I. D.; Ponce-de-Leon, A.; Riekstina, V.; Robert, J.; Royce, S.; Schaaf, H. S.; Seung, K. J.; Shah, L.; Shim, T. S.; Shin, S. S.; Shiraishi, Y.; Sifuentes-Osornio, J.; Sotgiu, G.; Strand, M. J.; Tabarsi, P.; Tupasi, T. E.; Van Altena, R.; Van der Walt, M.; Van der Werf, T. S.; Vargas, M. H.; Viiklepp, P.; Westenhouse, J.; Yew, W. W.; Yim, J. (PLOS, 2012-08-28)
    Background: Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of ...

  • South Africa—Serious about Biodiversity Science 

    Cherry, Michael (PLOS, 2005-05)
    In 1772, Carolus Linnaeus wrote a letter, now oft-quoted, to Ryk Tulbagh, the Governor of the Cape—in which he envied Tulbagh’s “sovereign control of that Paradise on Earth, the Cape of Good Hope, which the benefi cent ...

  • Corrective Action in Car Manufacturing 

    Rhone, H; Page, DC (Open Journal Systems, 1998)
    In this paper the important .issues involved in successfully implementing corrective action systems in quality management are discussed. The work is based on experience in implementing and operating such a system in an ...

  • A Non-Zero Sampling Plan for the Moderation of Examination Papers 

    van Wijck, W. (Open Journal Systems, 2007)
    The moderation of examination answer books is an area where quality assurance is essential, and should be employed to ensure that an examination paper’s standard, content and span, marking, etc. are fair and reasonable. ...

  • On the Comparison of Modern Production Management Philosophies 

    Sinclair, M. (Open Journal Systems, 1990)
    A variety of production management philosophies are discussed in the literature and implemented in industry. This paper will present a framework for the comparison of such management approaches. Each of the modern ...

  • Simply Optimal - Beyond EOQ for a Popular Class of Inventory Problems 

    van Wijck, W. (Open Journal Systems, 1999)
    True optimal solution s to real life problems are normally only achievable at the expense of great complexity. Every now and then however, one is almost stunned by the simplicity of a good solution to a practical problem. ...

  • Teaching Information Systems with a Project Oriented Course - A Case Study 

    Bekker, J. (Open Journal Systems, 2005)
    Many engineering students often find a course in less analytical subjects like Information Systems difficult due to the significant proportion of abstract concepts covered. To help the students understand them requires ...

  • An Effective Scheduling Scheme for Lift Clubs 

    van Wijck, W. (Open Journal Systems, 1998)
    This paper describes a formula for scheduling the day-to-day operation of a lift club. The formula is remarkably simple, and can easily be implemented on a spreadsheet. It is also extremely flexible and can cater for ...

  • The Industrial Engineer: Caught Between Two Revolutions? 

    du Preez, N.; Pintelon, L. (Open Journal Systems, 1994)
    The .Industrial Engineer is caught between the Industrial Revolution and the Information revolution. He is confronted with choosing between pragmatic improvements in productivity and efficiency of a single operation or ...

  • A Performance Management Model for Physical Asset Management 

    Jooste, J.L.; Page, D.C. (Open Journal Systems, 2004)
    There has been an emphasis shift from maintenance management towards asset management, where the focus is on reliable and operational equipment and on effective assets at optimum life-cycle costs. A challenge in the ...

  • A Case Study on MAximising the Profitability of a form Fill and Seal Machine by Optimising Interruption Intervals 

    Vlok, P.J.; Fourie, C.J. (Open Journal Systems, 2010)
    The practice of delivering consumer liquids in sachets, as opposed to alternative disposable packaging, has gained significant ground in the market in recent years because of environmental considerations, the cost benefit ...

  • Concurrent Engineering with Constraint Networks 

    Minnaar, Steve; Reinecke, Robert (Open Journal Systems, 1993)
    Concurrent engineering is a systematic approach to the integrated, concurrent design of products and their related processes, including manufacture and support. It allows the consideration of all elements of the product's ...

  • Now into big strides: report on statutory status for the South African Library and Information Services sector 

    Raju, R.; Witbooi, S.; Goosen, A. (Open Journal Systems, 2012)
    The road to acquiring statutory status for the Library and Information Services (LIS) sector in South Africa has been traversed numerous times over the last sixty to seventy years. In more recent years, there has been ...

  • Using the Population-based Incremental Learning Algorithm with Computer Simulation: Some Applications 

    Bekker, J.; Olivier, Y. (Open Journal Systems, 2008)
    The integration of the population-based incremental learning (PBIL) algorithm with computer simulation shows how this particular combination can be applied to find good solutions to combinatorial optimisation problems. ...

  • A Quantitative Analysis of Supply Response in the Namibian Mutton Industry 

    van Wyk, D. N.; Treurnicht, N.F. (Open Journal Systems, 2012)
    Agricultural activities in Namibia contribute 5.5% of Namibia’s GDP, while 70% of the population relies on agriculture for employment and day-to-day living. The purpose of this study is to investigate the relationships ...

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