• Patient diagnostic rate as indicator of tuberculosis case detection, South Africa 

      Claassens, Mareli M.; Van Schalkwyk, Cari; Dunbar, Rory; Ayles, Helen; Beyers, Nulda (Centers for Disease Control and PreventionPublisher's version, 2016)
      ENGLISH SUMMARY : To address the uncertainty of the indirectly measured tuberculosis case detection rate, we used survey data stratified by HIV status to calculate the patient diagnostic rate, a directly measurable indicator, ...
    • Pediatric tuberculosis : clinical and epidemiological reflections from a highly endemic setting 

      Hesseling, Anneke (BioMed Central, 2010-12)
      Pediatric TB provides unique opportunities to study TB disease epidemiology. Improved diagnostics are of key importance in order to address many of the challenges posed by TB in children. In the Western Cape Province in ...
    • Potential effect of household contact management on childhood tuberculosis : a mathematical modelling study 

      Dodd, Peter J.; Yuen, Courtney M,; Becerra, Mercedes C.; Revill, Paul; Jenkins, Helen E.; Seddon, James A. (Elsevier, 2018)
      Summary Background Tuberculosis is recognised as a major cause of morbidity and mortality in children, with most cases in children going undiagnosed and resulting in poor outcomes. Household contact management, which ...
    • Presentation and outcome of culture-confirmed isoniazid-resistant rifampicin-susceptible tuberculosis in children 

      Garcia-Prats, Anthony J.; Du Plessis, L.; Draper, H. R.; Burger, A.; Seddon, J. A.; Zimri, K.; Hesseling, Anneke C.; Schaaf, H. Simon (International Union Against Tuberculosis and Lung Disease, 2016)
      Setting: Isoniazid-resistant rifampicin-susceptible (HRRS) tuberculosis (TB) is the most prevalent form of drug-resistant TB globally, and may be a risk factor for poor outcomes. HRRS-TB in children has been poorly ...
    • Protecting children in low-income and middle-income countries from COVID-19 

      Ahmed, Salahuddin; Mvalo, Tisungane; Akech, Samuel; Agweyu, Ambrose; Baker, Kevin; Bar-Zeev, Naor; Campbell, Harry; Checkley, William; Chisti, Mohammod Jobayer; Colbourn, Tim; Cunningham, Steve; Duke, Trevor; English, Mike; Falade, Adegoke G.; Fancourt, Nicholas S. S.; Ginsburg, Amy S.; Graham, Hamish R.; Gray, Diane M.; Gupta, Madhu; Hammitt, Laura; Hesseling, Anneke C.; Hooli, Shubhada; Johnson, Abdul-Wahab B. R.; King, Carina; Kirby, Miles A.; Lanata, Claudio F.; Lufesi, Norman; Mackenzie, Grant A.; McCracken, John P.; Moschovis, Peter P.; Nair, Harish; Oviawe, Osawaru; Pomat, William S.; Santosham, Mathuram; Seddon, James A.; Thahane, Lineo Keneuoe; Wahl, Brian; Van der Zalm, Marieke; Verwey, Charl; Yoshida, Lay-Myint; Zar, Heather J.; Howie, Stephen R. C.; McCollum, Eric D. (BMJ, 2020)
      A saving grace of the COVID-19 pandemic in high-income and upper middle-income countries has been the relative sparing of children. As the disease spreads across low-income and middle-income countries (LMICs), ...
    • The rate of sputum smear-positive tuberculosis after treatment default in a high-burden setting : a retrospective cohort study 

      Marx, Florian M.; Dunbar, Rory; Enarson, Donald A.; Beyers, Nulda (PLoS, 2012-09)
      Rationale: High rates of recurrent tuberculosis after successful treatment have been reported from different high burden settings in Sub-Saharan Africa. However, little is known about the rate of smear-positive tuberculosis ...
    • Reducing deaths from severe pneumonia in children in Malawi by improving delivery of pneumonia case management 

      Enarson, Penelope M.; Gie, Robert P.; Mwansambo, Charles C.; Maganga, Ellubey R.; Lombard, Carl J.; Enarson, Donald A.; Graham, Stephen M. (PLoS, 2014-07-22)
      Objective: To evaluate the pneumonia specific case fatality rate over time following the implementation of a Child Lung Health Programme (CLHP) within the existing government health services in Malawi to improve delivery ...
    • Shorter treatment for minimal tuberculosis (TB) in children (SHINE) : a study protocol for a randomised controlled trial 

      Chabala, Chishala; Turkova, Anna; Thomason, Margaret J.; Wobudeya, Eric; Hissar, Syed; Mave, Vidya; Van Der Zalm, Marieke; Palmer, Megan; Kapasa, Monica; Bhavani, Perumal K.; Balaji, Sarath; Raichur, Priyanka A.; Demers, Anne-Marie; Hoddinott, Graeme; Owen-Powell, Ellen; Kinikar, Aarti; Musoke, Philippa; Mulenga, Veronica; Aarnoutse, Rob; McIlleron, Helen; Hesseling, Anneke; Crook, Angela M.; Cotton, Mark; Gibb, Diana M. (BioMed Central, 2018-04-19)
      Background: Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. Trials in ...
    • Spinning plates : livelihood mobility, household responsibility and anti-retroviral treatment in an urban Zambian community during the HPTN 071 (PopART) study 

      Bond, Virginia; Ngwenya, Fredrick; Thomas, Angelique; Simuyaba, Melvin; Hoddinott, Graeme; Fidler, Sarah; Hayes, Richard; Ayles, Helen; Seeley, Janet (Wiley Open Access, 2018)
      Introduction: Qualitative data are lacking on the impact of mobility among people living with HIV (PLHIV) and their decisionmaking around anti-retroviral treatment (ART). We describe challenges of juggling household ...
    • TB transmission is associated with prolonged stay in a low socio-economic, high burdened TB and HIV community in Cape Town, South Africa 

      Tadokera, Rebecca; Bekker, Linda-Gail; Kreiswirth, Barry N.; Mathema, Barun; Middelkoop, Keren (BMC (part of Springer Nature), 2020-02-10)
      Background: While several studies have assessed the associations between biological factors and tuberculosis (TB) transmission, our understanding of the associations between TB transmission and social and economic ...
    • Towards 90-90 : findings after two years of the HPTN 071 (PopART) cluster-randomized trial of a universal testing-and-treatment intervention in Zambia 

      Floyd, Sian; Ayles, Helen; Schaap, Albertus; Shanaube, Kwame; MacLeod, David; Phiri, Mwelwa; Griffith, Sam; Bock, Peter; Beyers, Nulda; Fidler, Sarah; Hayes, Richard (Public Library of Science, 2018)
      Background: HPTN071(PopART) is a 3-arm community-randomised study in 21 peri-urban/urban communities in Zambia and the Western Cape of South Africa, with high HIV prevalence and high mobility especially among young adults. ...
    • Tuberculosis control in South Africa : successes, challenges and recommendations 

      Churchyard, G. J.; Mametja, L. D.; Mvusi, L.; Ndjeka, N.; Hesseling, A. C.; Reid, A.; Babatunde, S.; Pillay, Y. (Health & Medical Publishing Group, 2014-03)
      Tuberculosis (TB) remains a global health threat, and South Africa (SA) has one of the world’s worst TB epidemics driven by HIV. Among the 22 countries with the highest burden of TB, SA has the highest estimated incidence ...
    • Tuberculosis control interventions targeted to previously treated people in a high-incidence setting : a modelling study 

      Marx, Florian M.; Yaesoubi, Reza; Menzies, Nicolas A.; Salomon, Joshua A.; Bilinski, Alyssa; Beyers, Nulda; Cohen, Ted (Elsevier, 2018-02-19)
      Background In high-incidence settings, recurrent disease among previously treated individuals contributes substantially to the burden of incident and prevalent tuberculosis. The extent to which interventions targeted to ...
    • Tuberculosis in healthcare workers and infections control measures at primary healthcare facilities in South Africa 

      Claassens, Mareli M.; Van Schalkwyk, Cari; Du Toit, Elizabeth; Roest, Eline; Lombard, Carl J.; Enarson, Donald A.; Beyers, Nulda; Borgdorff, Martien W. (Public Library of Science, 2013-10-02)
      Background Challenges exist regarding TB infection control and TB in hospital-based healthcare workers in South Africa. However, few studies report on TB in non-hospital based healthcare workers such as primary or ...
    • Understanding low sensitivity of community-based HIV rapid testing : experiences from the HPTN 071 (PopART) trial in Zambia and South Africa 

      Bock, Peter; Phiri, Comfort; Piwowar-Manning, Estelle; Kosloff, Barry; Mandla, Nomtha; Young, Alicia; James, Anelet; Schaap, A. b.; Scheepers, Michelle; Donnell, Deborah; Griffith, Sam; El-Sadr, Wafaa; Shanaube, Kwame; Beyers, Nulda; Hayes, Richard; Fidler, Sarah; Ayles, Helen (Wiley Open Access, 2017-08-27)
      Introduction: Population-wide HIV testing services (HTS) must be delivered in order to achieve universal antiretroviral treatment (ART) coverage. To accurately deliver HTS at such scale, non-facility-based HIV point-of-care ...
    • Vitamin D levels in Indian children with intrathoracic tuberculosis 

      Khandelwal, Deepchand; Gupta, Nandita; Mukherjee, Aparna; Lodha, Rakesh; Singh, Varinder; Grewal, Harleen M. S.; Bhatnagar, Shinjini; Singh, Sarman; Kabra, S. K.; Delhi Pediatric TB study group; Hesseling, A. C. (Medknow, 2014-10)
      Background & objectives: Deficiency of vitamin D, an immunomodulator agent, is associated with increased susceptibility to tuberculosis in adults, but only limited studies are available in the paediatric age group, especially ...
    • Where are we in the battle of ending tuberculosis in children and adolescents in South Africa? 

      Du Preez, K.; Seddon, J. A.; Schaaf, H. Simon; Hesseling, A. C. (Health & Medical Publishing Group, 2020)
      Ambitious targets to end tuberculosis (TB) were set at the United Nations General Assembly High-Level Meeting (UNHLM) on TB in September 2018, with children and adolescents specifically noted as key populations deserving ...