Browsing Desmond Tutu TB Centre (Tygerberg) by Title

Now showing items 10-20 of 20

    • The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts : a cross sectional study 

      Golla, Vera; Snow, Kathryn; Mandalakas, Anna M.; Schaaf, Simon H.; Du Preez, Karen; Hesseling, Anneke C.; Seddon, James A. (Biomed Central, 2017-08-29)
      ENGLISH SUMMARY : Background: The relative fitness of organisms causing drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) is unclear. We compared the risk of TB infection and TB disease in young child ...

    • Integration of TB and ART services fails to improve TB treatment outcomes : comparison of ART/TB primary healthcare services in Cape Town, South Africa 

      Kaplan, R.; Caldwell, J.; Bekker, L-G.; Jennings, K.; Lombard, C.; Enarson, D. A.; Wood, R.; Beyers, N. (Health & Medical Publishing Group, 2014-03)
      Background. The combined tuberculosis (TB) and HIV epidemics in South Africa (SA) have created enormous operational challenges for a health service that has traditionally run vertical programmes for TB treatment and ...

    • Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes : an individual patient data meta-analysis of 9,153 patients 

      Ahuja, Shama D.; Ashkin, David; Avendano, Monika; Banerjee, Rita; Bauer, Melissa; Bayona, Jamie N.; Becerra, Mercedes C.; Benedetti, Andrea; Burgos, Marcos; Centis, Rosella; Chan, Eward D.; Chiang, Chen-Yuan; Cox, Helen; D'Ambrosio, Lia; DeRiemer, Kathy; Dung, Nguyen Huy; Enarson, Donald; Falzon, Dennis; Flanagan, Katherine; Flood, Jennifer; Garcia-Garcia, Maria L.; Ghandi, Neel; Granich, Reuben M.; Hollm-Delgado, Maria G.; Holtz, Timothy H.; Iseman, Michael D.; Jarlsberg, Leah G.; Keshavjee, Salmaan; Kim, Hye-Ryoun; Koh, Won-Jung; Lancaster, Joey; Lange,Christophe; Lange, Wiel C. M. de; Leimane, Vaira; Leung, Chi Chiu; Li, Jiehui; Menzies, Dick; Migliori, Giovanni B.; Mishustin, Sergey P.; Mitnick, Carole D.; Narita, Masa; O'Riordan, Philly; Pai, Madhukar; Palmero, Domingo; Park, Seung-kyu; Pasvol, Geoffrey; Pena, Jose; Perez-Guzman, Carlos; Quelapio, Maria I. D.; Ponce-De-Leon, Alfredo; Riekstina, Vija; Robert, Jerome; Royce, Sarah; Schaaf, H. Simon; Seung, Kwonjune J.; Shah, Lena; Shim, Tae Sun; Shin, Sonya S.; Shiraishi, Yuji; Sifuentes-Osornio, Jose; Sotgiu, Giovanni; Strand, Matthew J.; Tabarsi, Payam; Tupasi, Thelma E.; Altena, Robert van; Van der Walt, Martie; Werf, Tjip S. van der; Vargas, Mario H.; Viiklepp, Pirett; Westenhouse, Janice; Yew, Wing Wai; Yim, Jae-Joon (Public Library of Science, 2012-08-28)
      Background: Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of ...

    • Patient diagnostic rate as indicator of tuberculosis case detection, South Africa 

      Claassens, Mareli M.; Van Schalkwyk, Cari; Dunbar, Rory; Ayles, Helen; Beyers, Nulda (Centers for Disease Control and PreventionPublisher's version, 2016)
      ENGLISH SUMMARY : To address the uncertainty of the indirectly measured tuberculosis case detection rate, we used survey data stratified by HIV status to calculate the patient diagnostic rate, a directly measurable indicator, ...

    • Pediatric tuberculosis : clinical and epidemiological reflections from a highly endemic setting 

      Hesseling, Anneke (BioMed Central, 2010-12)
      Pediatric TB provides unique opportunities to study TB disease epidemiology. Improved diagnostics are of key importance in order to address many of the challenges posed by TB in children. In the Western Cape Province in ...

    • The rate of sputum smear-positive tuberculosis after treatment default in a high-burden setting : a retrospective cohort study 

      Marx, Florian M.; Dunbar, Rory; Enarson, Donald A.; Beyers, Nulda (PLoS, 2012-09)
      Rationale: High rates of recurrent tuberculosis after successful treatment have been reported from different high burden settings in Sub-Saharan Africa. However, little is known about the rate of smear-positive tuberculosis ...

    • Reducing deaths from severe pneumonia in children in Malawi by improving delivery of pneumonia case management 

      Enarson, Penelope M.; Gie, Robert P.; Mwansambo, Charles C.; Maganga, Ellubey R.; Lombard, Carl J.; Enarson, Donald A.; Graham, Stephen M. (PLoS, 2014-07-22)
      Objective: To evaluate the pneumonia specific case fatality rate over time following the implementation of a Child Lung Health Programme (CLHP) within the existing government health services in Malawi to improve delivery ...

    • Shorter treatment for minimal tuberculosis (TB) in children (SHINE) : a study protocol for a randomised controlled trial 

      Chabala, Chishala; Turkova, Anna; Thomason, Margaret J.; Wobudeya, Eric; Hissar, Syed; Mave, Vidya; Van Der Zalm, Marieke; Palmer, Megan; Kapasa, Monica; Bhavani, Perumal K.; Balaji, Sarath; Raichur, Priyanka A.; Demers, Anne-Marie; Hoddinott, Graeme; Owen-Powell, Ellen; Kinikar, Aarti; Musoke, Philippa; Mulenga, Veronica; Aarnoutse, Rob; McIlleron, Helen; Hesseling, Anneke; Crook, Angela M.; Cotton, Mark; Gibb, Diana M. (BioMed Central, 2018-04-19)
      Background: Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. Trials ...

    • Tuberculosis control in South Africa : successes, challenges and recommendations 

      Churchyard, G. J.; Mametja, L. D.; Mvusi, L.; Ndjeka, N.; Hesseling, A. C.; Reid, A.; Babatunde, S.; Pillay, Y. (Health & Medical Publishing Group, 2014-03)
      Tuberculosis (TB) remains a global health threat, and South Africa (SA) has one of the world’s worst TB epidemics driven by HIV. Among the 22 countries with the highest burden of TB, SA has the highest estimated incidence ...

    • Tuberculosis in healthcare workers and infections control measures at primary healthcare facilities in South Africa 

      Claassens, Mareli M.; Van Schalkwyk, Cari; Du Toit, Elizabeth; Roest, Eline; Lombard, Carl J.; Enarson, Donald A.; Beyers, Nulda; Borgdorff, Martien W. (Public Library of Science, 2013-10-02)
      Background Challenges exist regarding TB infection control and TB in hospital-based healthcare workers in South Africa. However, few studies report on TB in non-hospital based healthcare workers such as primary or ...

    • Vitamin D levels in Indian children with intrathoracic tuberculosis 

      Khandelwal, Deepchand; Gupta, Nandita; Mukherjee, Aparna; Lodha, Rakesh; Singh, Varinder; Grewal, Harleen M. S.; Bhatnagar, Shinjini; Singh, Sarman; Kabra, S. K.; Delhi Pediatric TB study group; Hesseling, A. C. (Medknow, 2014-10)
      Background & objectives: Deficiency of vitamin D, an immunomodulator agent, is associated with increased susceptibility to tuberculosis in adults, but only limited studies are available in the paediatric age group, especially ...