Desmond Tutu TB Centre (Tygerberg)
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Has universal screening with Xpert® MTB/RIF increased the proportion of multidrugresistant tuberculosis cases diagnosed in a routine operational setting?
(Public Library of Science, 2017-02-15)Setting: Primary health services in Cape Town, South Africa where the introduction of Xpert® MTB/RIF (Xpert) enabled simultaneous screening for tuberculosis (TB) and drug susceptibility in all presumptive cases. Study ...
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Effect of non-tuberculous mycobacteria on host biomarkers potentially relevant for tuberculosis management
(PLoS, 2014-10-16)Background: Non-tuberculous mycobacteria (NTM) are different from Mycobacterium tuberculosis (MTB) both in their ubiquitous environmental distribution and in their reduced capacity to cause disease. While often neglected ...
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HPTN 071 (PopART) : a cluster-randomized trial of the population impact of an HIV combination prevention intervention including universal testing and treatment : mathematical model
(PLoS, 2014-01-15)Background: The HPTN 052 trial confirmed that antiretroviral therapy (ART) can nearly eliminate HIV transmission from successfully treated HIV-infected individuals within couples. Here, we present the mathematical modeling ...
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A comparison of multidrug-resistant tuberculosis treatment commencement times in MDRTBPlus line probe assay and XpertH MTB/RIF-based algorithms in a routine operational setting in Cape Town
(PLoS, 2014-07-31)Background: Xpert MTB/RIF was introduced as a screening test for all presumptive tuberculosis cases in primary health services in Cape Town, South Africa. Study Aim: To compare multidrug-resistant tuberculosis (MDR-TB) ...
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The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® Gold In-Tube response in a prospective study of healthy Indian adolescents
(PLoS, 2014-07-03)Background: QuantiFERON-TB Gold In-Tube (QFT) is an IFNγ-release assay used in the diagnosis of Mycobacterium tuberculosis (MTB) infection. The risk of TB progression increases with the magnitude of the MTB-specific ...
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Reducing deaths from severe pneumonia in children in Malawi by improving delivery of pneumonia case management
(PLoS, 2014-07-22)Objective: To evaluate the pneumonia specific case fatality rate over time following the implementation of a Child Lung Health Programme (CLHP) within the existing government health services in Malawi to improve delivery ...
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Vitamin D levels in Indian children with intrathoracic tuberculosis
(Medknow, 2014-10)Background & objectives: Deficiency of vitamin D, an immunomodulator agent, is associated with increased susceptibility to tuberculosis in adults, but only limited studies are available in the paediatric age group, especially ...
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Tuberculosis control in South Africa : successes, challenges and recommendations
(Health & Medical Publishing Group, 2014-03)Tuberculosis (TB) remains a global health threat, and South Africa (SA) has one of the world’s worst TB epidemics driven by HIV. Among the 22 countries with the highest burden of TB, SA has the highest estimated incidence ...
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Integration of TB and ART services fails to improve TB treatment outcomes : comparison of ART/TB primary healthcare services in Cape Town, South Africa
(Health & Medical Publishing Group, 2014-03)Background. The combined tuberculosis (TB) and HIV epidemics in South Africa (SA) have created enormous operational challenges for a health service that has traditionally run vertical programmes for TB treatment and ...
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Tuberculosis in healthcare workers and infections control measures at primary healthcare facilities in South Africa
(Public Library of Science, 2013-10-02)Background Challenges exist regarding TB infection control and TB in hospital-based healthcare workers in South Africa. However, few studies report on TB in non-hospital based healthcare workers such as primary or ...
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Comparing same day sputum microscopy with conventional sputum microscopy for the diagnosis of tuberculosis : Chhattisgarh, India
(Public Library of Science, 2013-09-23)Background The World Health Organization (WHO) recommends same day sputum microscopy (spot-spot) in preference to conventional strategy (spot-morning) for the diagnosis of smear positive tuberculosis with the view that ...
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HPTN 071 (PopART) : rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment - a study protocol for a cluster randomised trial
(BioMed Central, 2014-02)Abstract Background Effective interventions to reduce HIV incidence in sub-Saharan Africa are urgently needed. Mathematical modelling and the HIV Prevention Trials Network (HPTN) 052 trial ...
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The rate of sputum smear-positive tuberculosis after treatment default in a high-burden setting : a retrospective cohort study
(PLoS, 2012-09)Rationale: High rates of recurrent tuberculosis after successful treatment have been reported from different high burden settings in Sub-Saharan Africa. However, little is known about the rate of smear-positive tuberculosis ...
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Hearing loss in patients on treatment for drug-resistant tuberculosis
(European Respiratory Society, 2012-06)The treatment of drug‐resistant (DR) tuberculosis (TB) necessitates the use of second‐line injectable anti‐TB drugs which are associated with hearing loss. Hearing loss affects communication and for children the development ...
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Airway involvement in pulmonary tuberculosis
(Health & Medical Publishing Group, 2007-10)[No abstract available]
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Pediatric tuberculosis : clinical and epidemiological reflections from a highly endemic setting
(BioMed Central, 2010-12)Pediatric TB provides unique opportunities to study TB disease epidemiology. Improved diagnostics are of key importance in order to address many of the challenges posed by TB in children. In the Western Cape Province in ...
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