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Screening of four Cyclopia (honeybush) species for putative phyto-oestrogenic activity by oestrogen receptor binding assays

Verhoog, N. J. D.; Joubert, E.; Louw, Ann (AOSIS OpenJournals, 2007)

Phyto-oestrogens mediate an oestrogenic effect through binding to the oestrogen receptor (ER) subtypes, ERα and ERβ. Four commercially available Cyclopia (honeybush) species - C. intermedia, C. subternata, C. genistoides ...

South African herbal teas : Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review

Joubert, E.; Gelderblom, W. C. A.; Louw, Ann; De Beer, D. (Elsevier, 2008-10)

Rooibos (Aspalathus linearis (Brum.f) Dahlg.) and honeybush (Cyclopia Vent. species) are popular indigenous South African herbal teas enjoyed for their taste and aroma. Traditional medicinal uses of rooibos in South ...

Not all progestins are the same : implications for usage

Hapgood, Janet P.; Koubovec, Dominique; Louw, Ann; Africander, Donita (Elsevier, 2004-11)

Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecularmechanisms of ...

Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chloride

Louw, Ann; Allie, F.; Swart, A. C.; Swart, P. (Informa Healthcare, 2000)

The interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis ...

A fully dissociated compound of plant origin for inflammatory gene repression

De Bosscher, Karolien; Van den Berghe, Wim; Beck, Ilse M. E.; Van Molle, Wim; Hennuyer, Nathalie; Hapgood, Janet; Liber, Claude; Staels, Bart; Louw, Ann; Haegeman, Guy (PNAS, 2005-11)

The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating ...

Evaluation of the phytoestrogenic activity of Cyclopia genistoides (honeybush) methanol extracts and relevant polyphenols

Verhoog, Nicolette J. D.; Joubert, Elizabeth; Louw, Ann (American Chemical Society, 2007-04)

Unfermented C. genistoides methanol extracts of different harvestings and selected polyphenols were evaluated for phytoestrogenic activity by comparing binding to both ER subtypes, transactivation of an ERE-containing ...