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Cyclopia extracts act as ERα antagonists and ERβ agonists, in vitro and in vivo
(Public Library of Science (PLOS), 2013-11)
Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search
for new generations of estrogen analogues that would maintain estrogen benefits without associated ...
Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ
(2014-10)
Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs). It also modulates the bioavailability of GCs, as only free ...
Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution
(Elsevier, 2013-02)
Glucocorticoid receptor (GR) concentrations and the ability of the GR to dimerize are factors which influence
sensitivity to glucocorticoids. Upon glucocorticoid binding, the GR is actively transported into the
nucleus, ...
Impact of glucocorticoid receptor density on ligand- independent dimerization, cooperative ligand-binding and basal priming of transactivation : a cell culture model
(Public Library of Science -- PLoS, 2013-05)
Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and
pharmacological effectors. However, the effects and implications of differences in GR concentration have not ...
Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats
(The Endocrine Society, 1999-05)
Salsola tuberculatiformis Botschantzev causes prolonged gestation
in sheep and contraception in rats. An active fraction isolated
from the shrub, containing a highly labile hydoxyphenyl aziridine or
precursor, and a ...
Screening of four Cyclopia (honeybush) species for putative phyto-oestrogenic activity by oestrogen receptor binding assays
(AOSIS OpenJournals, 2007)
Phyto-oestrogens mediate an oestrogenic effect through binding to the oestrogen receptor (ER) subtypes, ERα and ERβ. Four commercially available Cyclopia (honeybush) species - C. intermedia, C. subternata, C. genistoides ...
Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A
(HighWire Press, 2010-03)
Compound A (CpdA), a dissociated glucocorticoid receptor
modulator, decreases corticosteroid-binding globulin (CBG),
adrenocorticotropic hormone (ACTH), and luteneinizing
hormone levels in rats. Whether this is due to ...
Interplay of the inflammatory and stress systems in a hepatic cell line : interactions between glucocorticoid receptor agonists and interleukin-6
(HighWire Press, 2010-11)
The liver plays an important role in inflammation and stress by producing the acute phase proteins
(APPs) required for resolution of inflammation as well as by delivering systemic glucose, through
gluconeogenesis, required ...
South African herbal teas : Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review
(Elsevier, 2008-10)
Rooibos (Aspalathus linearis (Brum.f) Dahlg.) and honeybush (Cyclopia Vent. species) are popular indigenous
South African herbal teas enjoyed for their taste and aroma. Traditional medicinal uses of rooibos in
South ...
Phytoestrogenic potential of Cyclopia extracts and polyphenols
(Georg Thieme Verlag, 2013-05)
Cyclopia Vent. species, commonly known as honeybush, are endemic to Southern Africa. The plant is traditionally used as an herbal tea but several health benefits have recently been recorded. This minireview presents an ...