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Now showing items 1-20 of 24

    • 11β-Hydroxyandrostenedione returns to the steroid arena : biosynthesis, metabolism and function 

      Bloem, Liezl M.; Storbeck, Karl-Heinz; Schloms, Lindie; Swart, Amanda C. (MDPI, 2013-10)
      The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway ...

    • A fully dissociated compound of plant origin for inflammatory gene repression 

      De Bosscher, Karolien; Van den Berghe, Wim; Beck, Ilse M. E.; Van Molle, Wim; Hennuyer, Nathalie; Hapgood, Janet; Liber, Claude; Staels, Bart; Louw, Ann; Haegeman, Guy (PNAS, 2005-11)
      The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating ...

    • Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A 

      Robertson, Steven; Allie-Reid, Fatima; Vanden Berghe, Wim; Visser, Koch; Binder, Anke; Africander, Donita; Vismer, Michael; De Bosscher, Karolien; Hapgood, Janet; Haegeman, Guy; Louw, Ann (HighWire Press, 2010-03)
      Compound A (CpdA), a dissociated glucocorticoid receptor modulator, decreases corticosteroid-binding globulin (CBG), adrenocorticotropic hormone (ACTH), and luteneinizing hormone levels in rats. Whether this is due to ...

    • Consistent phenological shifts in the making of a biodiversity hotspot : the Cape flora 

      Warren, Ben H.; Bakker, Freek T.; Bellstedt, Dirk U.; Bytebier, Benny; Claszen-Bockhoff, Regine; Dreyer, Leanne L.; Edwards, Dawn; Forest, Felix; Galley, Chloe; Hardy, Christopher R.; Linder, H. Peter; Muasya, A. Muthama; Mummenhoff, Klaus; Oberlander, Kenneth C.; Quint, Marcus; Richardson, James E.; Savolainen, Vincent; Schrire, Brian D.; Van der Niet, Timotheus; Verboom, G. Anthony; Yesson, Christopher; Hawkins, Julie A. (BioMed Central, 2011-02)
      ABSTRACT: Background: The best documented survival responses of organisms to past climate change on short (glacial-interglacial) timescales are distributional shifts. Despite ample evidence on such timescales for local ...

    • Cyclopia extracts act as ERα antagonists and ERβ agonists, in vitro and in vivo 

      Visser, Koch; Mortimer, Morne; Louw, Ann (Public Library of Science (PLOS), 2013-11)
      Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search for new generations of estrogen analogues that would maintain estrogen benefits without associated ...

    • Evaluation of the phytoestrogenic activity of Cyclopia genistoides (honeybush) methanol extracts and relevant polyphenols 

      Verhoog, Nicolette J. D.; Joubert, Elizabeth; Louw, Ann (American Chemical Society, 2007-04)
      Unfermented C. genistoides methanol extracts of different harvestings and selected polyphenols were evaluated for phytoestrogenic activity by comparing binding to both ER subtypes, transactivation of an ERE-containing ...

    • Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution 

      Robertson, Steven; Hapgood, Janet P.; Louw, Ann (Elsevier, 2013-02)
      Glucocorticoid receptor (GR) concentrations and the ability of the GR to dimerize are factors which influence sensitivity to glucocorticoids. Upon glucocorticoid binding, the GR is actively transported into the nucleus, ...

    • Impact of glucocorticoid receptor density on ligand- independent dimerization, cooperative ligand-binding and basal priming of transactivation : a cell culture model 

      Robertson, Steven; Rohwer, Johann M.; Hapgood, Janet P; Louw, Ann (Public Library of Science -- PLoS, 2013-05)
      Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and pharmacological effectors. However, the effects and implications of differences in GR concentration have not ...

    • Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ 

      Verhoog, Nicolette; Allie-Reid, Fatima; Vanden Berghe, Wim; Smith, Carine; Haegeman, Guy; Hapgood, Janet; Louw, Ann (2014-10)
      Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs). It also modulates the bioavailability of GCs, as only free ...

    • Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chloride 

      Louw, Ann; Allie, F.; Swart, A. C.; Swart, P. (Informa Healthcare, 2000)
      The interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis ...

    • Interplay of the inflammatory and stress systems in a hepatic cell line : interactions between glucocorticoid receptor agonists and interleukin-6 

      Visser, Koch; Smith, Carine; Louw, Ann (HighWire Press, 2010-11)
      The liver plays an important role in inflammation and stress by producing the acute phase proteins (APPs) required for resolution of inflammation as well as by delivering systemic glucose, through gluconeogenesis, required ...

    • The logic of kinetic regulation in the thioredoxin system 

      Pillay, Che S.; Hofmeyr, Jan-Hendrik S.; Rohwer, Johann M. (BioMed Central, 2011-01)
      Abstract: Background: The thioredoxin system consisting of NADP(H), thioredoxin reductase and thioredoxin provides reducing equivalents to a large and diverse array of cellular processes. Despite a great deal of information ...

    • Lysosomal disruption during the development of endotoxic shock in the baboon 

      Janson, P. M. C.; Kuhn, S. H.; Geldenhuys, J. J. (Health and Medical Publishing Group (HMPG), 1975-06)
      Lysosomal disruption with release of lysosomal enzymes has been described in shock. This study was designed to demonstrate the release of lysosomal enzymes in the liver and lung in addition to determining circulating serum ...

    • Minimum information about a simulation experiment (MIASE) 

      Waltemath, Dagmar; Adams, Richard; Beard, Daniel A.; Bergmann, Frank T.; Balla, Upinder S.; Britten, Randall; Chelliah, Vijayalakshmi; Cooling, Michael T.; Cooper, Jonathan; Crampin, Edmund J.; Garny, Alan; Hoops, Stefan; Hucka, Michael; Hunter, Peter; Klipp, Edda; Laibe, Camille; Miller, Andrew K.; Moraru, Ion; Nickerson, David; Nielsen, Poul; Nikolski, Macha; Sahle, Sven; Sauro, Herbert M.; Schmidt, Henning; Snoep, Jacky L.; Tolle, Dominic; Wolkenhauer, Olaf; Le Novere, Nicolas (PLOS, 2011-04)
      Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ...

    • New and interesting orchid records for Tanzania 

      Bytebier, Benny; Sakwa, Jane; Kurzweil, Hubert (BioOne, 2004-01)
      The orchid taxa Brachycorythis ovata subsp. schweinfurthii, Habenaria arianae and Habenaria disparilis are newly recorded for Tanzania, while Brachycorythis congoensis is newly recorded for the floral region T7. A stable, ...

    • A new species of Streptocarpus (Gesneriaceae) endemic to Madagascar 

      MacMaster, Gwyneth; Moller, Michael; Hughes, Mark; Edwards, Trevor J.; Bellstedt, Dirk U. (Museum Nationale d'Histoire Naturelle Paris, 2005-03)
      A new species of Streptocarpus (S. lanatus MacMaster) is described from central Madagascar. Material referable to this new taxon was previously assigned to S. ibityensis Humbert, from which it can be distinguished by its ...

    • Not all progestins are the same : implications for usage 

      Hapgood, Janet P.; Koubovec, Dominique; Louw, Ann; Africander, Donita (Elsevier, 2004-11)
      Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecularmechanisms of ...

    • Pantothenamides are potent, on-target inhibitors of plasmodium falciparum growth when serum pantetheinase is inactivated 

      Spry, Christina; Macuamule, Cristiano; Lin, Zhiyang; Virga, Kristopher G.; Lee, Richard E.; Strauss, Erick; Saliba, Kevin J. (PLoS, 2013-02)
      Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B5) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate ...

    • Phytoestrogenic potential of Cyclopia extracts and polyphenols 

      Louw, Ann; Joubert, Elizabeth; Visser, Koch (Georg Thieme Verlag, 2013-05)
      Cyclopia Vent. species, commonly known as honeybush, are endemic to Southern Africa. The plant is traditionally used as an herbal tea but several health benefits have recently been recorded. This minireview presents an ...

    • Reproducible computational biology experiments with SED-ML -The Simulation Experiment Description Markup Language 

      Waltemath, Dagmar; Adams, Richard; Bergmann, Frank T.; Hucka, Michael; Kolpakov, Fedor; Miller, Andrew K.; Moraru, Ion I.; Nickerson, David; Sahle, Sven; Snoep, Jacky L.; Le Novere, Nicolas (BioMed Central, 2011-12)
      Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments. The recently published Minimum ...