Browsing Research Articles (Biochemistry) by Title

Now showing items 1-20 of 24

  • 11β-Hydroxyandrostenedione returns to the steroid arena : biosynthesis, metabolism and function 

    Bloem, Liezl M.; Storbeck, Karl-Heinz; Schloms, Lindie; Swart, Amanda C. (MDPI, 2013-10)
    The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway ...

  • A fully dissociated compound of plant origin for inflammatory gene repression 

    De Bosscher, Karolien; Van den Berghe, Wim; Beck, Ilse M. E.; Van Molle, Wim; Hennuyer, Nathalie; Hapgood, Janet; Liber, Claude; Staels, Bart; Louw, Ann; Haegeman, Guy (PNAS, 2005-11)
    The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating ...

  • Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A 

    Robertson, Steven; Allie-Reid, Fatima; Vanden Berghe, Wim; Visser, Koch; Binder, Anke; Africander, Donita; Vismer, Michael; De Bosscher, Karolien; Hapgood, Janet; Haegeman, Guy; Louw, Ann (HighWire Press, 2010-03)
    Compound A (CpdA), a dissociated glucocorticoid receptor modulator, decreases corticosteroid-binding globulin (CBG), adrenocorticotropic hormone (ACTH), and luteneinizing hormone levels in rats. Whether this is due to ...

  • Consistent phenological shifts in the making of a biodiversity hotspot : the Cape flora 

    Warren, Ben H.; Bakker, Freek T.; Bellstedt, Dirk U.; Bytebier, Benny; Claszen-Bockhoff, Regine; Dreyer, Leanne L.; Edwards, Dawn; Forest, Felix; Galley, Chloe; Hardy, Christopher R.; Linder, H. Peter; Muasya, A. Muthama; Mummenhoff, Klaus; Oberlander, Kenneth C.; Quint, Marcus; Richardson, James E.; Savolainen, Vincent; Schrire, Brian D.; Van der Niet, Timotheus; Verboom, G. Anthony; Yesson, Christopher; Hawkins, Julie A. (BioMed Central, 2011-02)
    ABSTRACT: Background: The best documented survival responses of organisms to past climate change on short (glacial-interglacial) timescales are distributional shifts. Despite ample evidence on such timescales for local ...

  • Cyclopia extracts act as ERα antagonists and ERβ agonists, in vitro and in vivo 

    Visser, Koch; Mortimer, Morne; Louw, Ann (Public Library of Science (PLOS), 2013-11)
    Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search for new generations of estrogen analogues that would maintain estrogen benefits without associated ...

  • Evaluation of the phytoestrogenic activity of Cyclopia genistoides (honeybush) methanol extracts and relevant polyphenols 

    Verhoog, Nicolette J. D.; Joubert, Elizabeth; Louw, Ann (American Chemical Society, 2007-04)
    Unfermented C. genistoides methanol extracts of different harvestings and selected polyphenols were evaluated for phytoestrogenic activity by comparing binding to both ER subtypes, transactivation of an ERE-containing ...

  • Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution 

    Robertson, Steven; Hapgood, Janet P.; Louw, Ann (Elsevier, 2013-02)
    Glucocorticoid receptor (GR) concentrations and the ability of the GR to dimerize are factors which influence sensitivity to glucocorticoids. Upon glucocorticoid binding, the GR is actively transported into the nucleus, ...

  • Impact of glucocorticoid receptor density on ligand- independent dimerization, cooperative ligand-binding and basal priming of transactivation : a cell culture model 

    Robertson, Steven; Rohwer, Johann M.; Hapgood, Janet P; Louw, Ann (Public Library of Science -- PLoS, 2013-05)
    Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and pharmacological effectors. However, the effects and implications of differences in GR concentration have not ...

  • Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ 

    Verhoog, Nicolette; Allie-Reid, Fatima; Vanden Berghe, Wim; Smith, Carine; Haegeman, Guy; Hapgood, Janet; Louw, Ann (2014-10)
    Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs). It also modulates the bioavailability of GCs, as only free ...

  • Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chloride 

    Louw, Ann; Allie, F.; Swart, A. C.; Swart, P. (Informa Healthcare, 2000)
    The interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis ...

  • Interplay of the inflammatory and stress systems in a hepatic cell line : interactions between glucocorticoid receptor agonists and interleukin-6 

    Visser, Koch; Smith, Carine; Louw, Ann (HighWire Press, 2010-11)
    The liver plays an important role in inflammation and stress by producing the acute phase proteins (APPs) required for resolution of inflammation as well as by delivering systemic glucose, through gluconeogenesis, required ...

  • The logic of kinetic regulation in the thioredoxin system 

    Pillay, Che S.; Hofmeyr, Jan-Hendrik S.; Rohwer, Johann M. (BioMed Central, 2011-01)
    Abstract: Background: The thioredoxin system consisting of NADP(H), thioredoxin reductase and thioredoxin provides reducing equivalents to a large and diverse array of cellular processes. Despite a great deal of information ...

  • Lysosomal disruption during the development of endotoxic shock in the baboon 

    Janson, P. M. C.; Kuhn, S. H.; Geldenhuys, J. J. (Health and Medical Publishing Group (HMPG), 1975-06)
    Lysosomal disruption with release of lysosomal enzymes has been described in shock. This study was designed to demonstrate the release of lysosomal enzymes in the liver and lung in addition to determining circulating serum ...

  • Minimum information about a simulation experiment (MIASE) 

    Waltemath, Dagmar; Adams, Richard; Beard, Daniel A.; Bergmann, Frank T.; Balla, Upinder S.; Britten, Randall; Chelliah, Vijayalakshmi; Cooling, Michael T.; Cooper, Jonathan; Crampin, Edmund J.; Garny, Alan; Hoops, Stefan; Hucka, Michael; Hunter, Peter; Klipp, Edda; Laibe, Camille; Miller, Andrew K.; Moraru, Ion; Nickerson, David; Nielsen, Poul; Nikolski, Macha; Sahle, Sven; Sauro, Herbert M.; Schmidt, Henning; Snoep, Jacky L.; Tolle, Dominic; Wolkenhauer, Olaf; Le Novere, Nicolas (PLOS, 2011-04)
    Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ...

  • New and interesting orchid records for Tanzania 

    Bytebier, Benny; Sakwa, Jane; Kurzweil, Hubert (BioOne, 2004-01)
    The orchid taxa Brachycorythis ovata subsp. schweinfurthii, Habenaria arianae and Habenaria disparilis are newly recorded for Tanzania, while Brachycorythis congoensis is newly recorded for the floral region T7. A stable, ...

  • A new species of Streptocarpus (Gesneriaceae) endemic to Madagascar 

    MacMaster, Gwyneth; Moller, Michael; Hughes, Mark; Edwards, Trevor J.; Bellstedt, Dirk U. (Museum Nationale d'Histoire Naturelle Paris, 2005-03)
    A new species of Streptocarpus (S. lanatus MacMaster) is described from central Madagascar. Material referable to this new taxon was previously assigned to S. ibityensis Humbert, from which it can be distinguished by its ...

  • Not all progestins are the same : implications for usage 

    Hapgood, Janet P.; Koubovec, Dominique; Louw, Ann; Africander, Donita (Elsevier, 2004-11)
    Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecularmechanisms of ...

  • Phytoestrogenic potential of Cyclopia extracts and polyphenols 

    Louw, Ann; Joubert, Elizabeth; Visser, Koch (Georg Thieme Verlag, 2013-05)
    Cyclopia Vent. species, commonly known as honeybush, are endemic to Southern Africa. The plant is traditionally used as an herbal tea but several health benefits have recently been recorded. This minireview presents an ...

  • The recent recombinant evolution of a major crop pathogen, potato virus Y 

    Visser, Johan Christiaan; Bellstedt, Dirk Uwe; Pirie, Michael David (PLOS, 2012-11-30)
    Potato virus Y (PVY) is a major agricultural disease that reduces crop yields worldwide. Different strains of PVY are associated with differing degrees of pathogenicity, of which the most common and economically important ...

  • Reproducible computational biology experiments with SED-ML -The Simulation Experiment Description Markup Language 

    Waltemath, Dagmar; Adams, Richard; Bergmann, Frank T.; Hucka, Michael; Kolpakov, Fedor; Miller, Andrew K.; Moraru, Ion I.; Nickerson, David; Sahle, Sven; Snoep, Jacky L.; Le Novere, Nicolas (BioMed Central, 2011-12)
    Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments. The recently published Minimum ...