Browsing Research Articles (Biochemistry) by Title

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Browsing Research Articles (Biochemistry) by Title

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  • Bloem, Liezl M.   Storbeck, Karl-Heinz   Schloms, Lindie   Swart, Amanda C. (MDPI, 2013-10)
    The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway ...
  • De Bosscher, Karolien   Van den Berghe, Wim   Beck, Ilse M. E.   Van Molle, Wim   Hennuyer, Nathalie   Hapgood, Janet   Liber, Claude   Staels, Bart   Louw, Ann   Haegeman, Guy (PNAS, 2005-11)
    The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating ...
  • Robertson, Steven   Allie-Reid, Fatima   Vanden Berghe, Wim   Visser, Koch   Binder, Anke   Africander, Donita   Vismer, Michael   De Bosscher, Karolien   Hapgood, Janet   Haegeman, Guy   Louw, Ann (HighWire Press, 2010-03)
    Compound A (CpdA), a dissociated glucocorticoid receptor modulator, decreases corticosteroid-binding globulin (CBG), adrenocorticotropic hormone (ACTH), and luteneinizing hormone levels in rats. Whether this is due to ...
  • Warren, Ben H.   Bakker, Freek T.   Bellstedt, Dirk U.   Bytebier, Benny   Claszen-Bockhoff, Regine   Dreyer, Leanne L.   Edwards, Dawn   Forest, Felix   Galley, Chloe   Hardy, Christopher R.   Linder, H. Peter   Muasya, A. Muthama   Mummenhoff, Klaus   Oberlander, Kenneth C.   Quint, Marcus   Richardson, James E.   Savolainen, Vincent   Schrire, Brian D.   Van der Niet, Timotheus   Verboom, G. Anthony   Yesson, Christopher   Hawkins, Julie A. (BioMed Central, 2011-02)
    ABSTRACT: Background: The best documented survival responses of organisms to past climate change on short (glacial-interglacial) timescales are distributional shifts. Despite ample evidence on such timescales for local ...
  • Visser, Koch   Mortimer, Morne   Louw, Ann (Public Library of Science (PLOS), 2013-11)
    Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search for new generations of estrogen analogues that would maintain estrogen benefits without associated ...
  • Verhoog, Nicolette J. D.   Joubert, Elizabeth   Louw, Ann (American Chemical Society, 2007-04)
    Unfermented C. genistoides methanol extracts of different harvestings and selected polyphenols were evaluated for phytoestrogenic activity by comparing binding to both ER subtypes, transactivation of an ERE-containing ...
  • Robertson, Steven   Hapgood, Janet P.   Louw, Ann (Elsevier, 2013-02)
    Glucocorticoid receptor (GR) concentrations and the ability of the GR to dimerize are factors which influence sensitivity to glucocorticoids. Upon glucocorticoid binding, the GR is actively transported into the nucleus, ...
  • Robertson, Steven   Rohwer, Johann M.   Hapgood, Janet P   Louw, Ann (Public Library of Science -- PLoS, 2013-05)
    Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and pharmacological effectors. However, the effects and implications of differences in GR concentration have not ...
  • Louw, Ann   Allie, F.   Swart, A. C.   Swart, P. (Informa Healthcare, 2000)
    The interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis ...
  • Visser, Koch   Smith, Carine   Louw, Ann (HighWire Press, 2010-11)
    The liver plays an important role in inflammation and stress by producing the acute phase proteins (APPs) required for resolution of inflammation as well as by delivering systemic glucose, through gluconeogenesis, required ...
  • Pillay, Che S.   Hofmeyr, Jan-Hendrik S.   Rohwer, Johann M. (BioMed Central, 2011-01)
    Abstract: Background: The thioredoxin system consisting of NADP(H), thioredoxin reductase and thioredoxin provides reducing equivalents to a large and diverse array of cellular processes. Despite a great deal of information ...
  • Janson, P. M. C.   Kuhn, S. H.   Geldenhuys, J. J. (Health and Medical Publishing Group (HMPG), 1975-06)
    Lysosomal disruption with release of lysosomal enzymes has been described in shock. This study was designed to demonstrate the release of lysosomal enzymes in the liver and lung in addition to determining circulating serum ...
  • Waltemath, Dagmar   Adams, Richard   Beard, Daniel A.   Bergmann, Frank T.   Balla, Upinder S.   Britten, Randall   Chelliah, Vijayalakshmi   Cooling, Michael T.   Cooper, Jonathan   Crampin, Edmund J.   Garny, Alan   Hoops, Stefan   Hucka, Michael   Hunter, Peter   Klipp, Edda   Laibe, Camille   Miller, Andrew K.   Moraru, Ion   Nickerson, David   Nielsen, Poul   Nikolski, Macha   Sahle, Sven   Sauro, Herbert M.   Schmidt, Henning   Snoep, Jacky L.   Tolle, Dominic   Wolkenhauer, Olaf   Le Novere, Nicolas (PLOS, 2011-04)
    Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ...
  • Bytebier, Benny   Sakwa, Jane   Kurzweil, Hubert (BioOne, 2004-01)
    The orchid taxa Brachycorythis ovata subsp. schweinfurthii, Habenaria arianae and Habenaria disparilis are newly recorded for Tanzania, while Brachycorythis congoensis is newly recorded for the floral region T7. A stable, ...
  • MacMaster, Gwyneth   Moller, Michael   Hughes, Mark   Edwards, Trevor J.   Bellstedt, Dirk U. (Museum Nationale d'Histoire Naturelle Paris, 2005-03)
    A new species of Streptocarpus (S. lanatus MacMaster) is described from central Madagascar. Material referable to this new taxon was previously assigned to S. ibityensis Humbert, from which it can be distinguished by its ...
  • Hapgood, Janet P.   Koubovec, Dominique   Louw, Ann   Africander, Donita (Elsevier, 2004-11)
    Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecularmechanisms of ...
  • Louw, Ann   Joubert, Elizabeth   Visser, Koch (Georg Thieme Verlag, 2013-05)
    Cyclopia Vent. species, commonly known as honeybush, are endemic to Southern Africa. The plant is traditionally used as an herbal tea but several health benefits have recently been recorded. This minireview presents an ...
  • Visser, Johan Christiaan   Bellstedt, Dirk Uwe   Pirie, Michael David (PLOS, 2012-11-30)
    Potato virus Y (PVY) is a major agricultural disease that reduces crop yields worldwide. Different strains of PVY are associated with differing degrees of pathogenicity, of which the most common and economically important ...
  • Waltemath, Dagmar   Adams, Richard   Bergmann, Frank T.   Hucka, Michael   Kolpakov, Fedor   Miller, Andrew K.   Moraru, Ion I.   Nickerson, David   Sahle, Sven   Snoep, Jacky L.   Le Novere, Nicolas (BioMed Central, 2011-12)
    Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments. The recently published Minimum ...
  • Schloms, Lindie   Swart, Amanda C. (MDPI, 2014-03)
    Major rooibos flavonoids—dihydrochalcones, aspalathin and nothofagin, flavones—orientin and vitexin, and a flavonol, rutin, were investigated to determine their influence on the activity of adrenal steroidogenic enzymes, ...