Research Articles (Biochemistry)

Minimum information about a simulation experiment (MIASE)

Waltemath, Dagmar Adams, Richard Beard, Daniel A. Bergmann, Frank T. Balla, Upinder S. Britten, Randall Chelliah, Vijayalakshmi Cooling, Michael T. Cooper, Jonathan Crampin, Edmund J. Garny, Alan Hoops, Stefan Hucka, Michael Hunter, Peter Klipp, Edda Laibe, Camille Miller, Andrew K. Moraru, Ion Nickerson, David Nielsen, Poul Nikolski, Macha Sahle, Sven Sauro, Herbert M. Schmidt, Henning Snoep, Jacky L. Tolle, Dominic Wolkenhauer, Olaf Le Novere, Nicolas (PLOS, 2011-04)

Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in ...

Reproducible computational biology experiments with SED-ML -The Simulation Experiment Description Markup Language

Waltemath, Dagmar Adams, Richard Bergmann, Frank T. Hucka, Michael Kolpakov, Fedor Miller, Andrew K. Moraru, Ion I. Nickerson, David Sahle, Sven Snoep, Jacky L. Le Novere, Nicolas (BioMed Central, 2011-12)

Background: The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments. The recently published Minimum ...

Investigation of the primary cause of hypoadrenocorticism in South African Angora goats (Capra aegagrus) : a comparison with Boer goats (Capra hircus) and Merino sheep (Ovis aries)

Engelbrecht, Y. Herselman, T. Louw, Ann Swart, P. (American Society of Animal Science, 2000-02)

Our objective was to identify the primary site of the reduced adrenal function in South African Angora goats (Capra aegagrus) that causes a decrease in cortisol production and leads to severe losses of Angora goats ...

Synthetic progestins used in HRT have different glucocorticoid agonist properties

Koubovec, Dominique Ronacher, Katharina Stubsrud, Elisabeth Louw, Ann Hapgood, Janet Patricia (Elsevier, 2005-08)

The synthetic progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-EN or NET-A), are widely used as female contraceptive agents and in hormone replacement therapy (HRT). Competitive binding revealed ...

South African herbal teas : Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review

Joubert, E. Gelderblom, W. C. A. Louw, Ann De Beer, D. (Elsevier, 2008-10)

Rooibos (Aspalathus linearis (Brum.f) Dahlg.) and honeybush (Cyclopia Vent. species) are popular indigenous South African herbal teas enjoyed for their taste and aroma. Traditional medicinal uses of rooibos in South ...

Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats

Louw, Ann Swart, P. (The Endocrine Society, 1999-05)

Salsola tuberculatiformis Botschantzev causes prolonged gestation in sheep and contraception in rats. An active fraction isolated from the shrub, containing a highly labile hydoxyphenyl aziridine or precursor, and a ...

Biological activities of the shrub Salsola tuberculatiformis Botsch. : contraceptive or stress alleviator?

Swart, Pieter Swart, Amanda C. Louw, Ann Van Der Merwe, Kirsten J. (Wiley-VCH Verlag Berlin, 2003-06)

Plants belonging to the genus Salsola (Family: Chenopodiaceae) are common in the arid and semiarid regions of our planet with no less than 69 different Salsola species found in Namibia and the Republic of South Africa. This ...

Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity

Avenant, Chanel Ronacher, Katharina Stubsrud, Elisabeth Louw, Ann Hapgood, Janet P. (Elsevier, 2010-10)

A central question in glucocorticoid mechanism of action via the glucocorticoid receptor (GR) is what determines ligand-selective transcriptional responses. Using a panel of 12 GR ligands, we show that the extent of GR ...

Selective extraction of Cyclopia for enhanced in vitro phytoestrogenicity and benchmarking against commercial phytoestrogen extracts

Mfenyana, Ciko De Beer, Dalene Joubert, Elizabeth Louw, Ann (Elsevier, 2008-11)

Previous work established the phytoestrogenicity of “unfermented” Cyclopia (honeybush) extracts. The current study investigated the phytoestrogenicity of four Cyclopia harvestings (M6–9) for preparation of extracts with ...

Anti-androgenic properties of Compound A, an analog of a nonsteroidal plant compound

Tanner, T. M. Verrijdt, G. Rombauts, W. Louw, Ann Hapgood, Janet P. (Elsevier, 2003-2)

We investigated the interactions between Compound A (CpdA), an analog of a hydroxyphenyl aziridine precursor found in an African shrub, and the androgen receptor (AR). CpdA represses androgen-induced activation of both ...

Not all progestins are the same : implications for usage

Hapgood, Janet P. Koubovec, Dominique Louw, Ann Africander, Donita (Elsevier, 2004-11)

Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecularmechanisms of ...

Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chloride

Louw, Ann Allie, F. Swart, A. C. Swart, P. (Informa Healthcare, 2000)

The interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis ...

Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A

Robertson, Steven Allie-Reid, Fatima Vanden Berghe, Wim Visser, Koch Binder, Anke Africander, Donita Vismer, Michael De Bosscher, Karolien Hapgood, Janet Haegeman, Guy Louw, Ann (HighWire Press, 2010-03)

Compound A (CpdA), a dissociated glucocorticoid receptor modulator, decreases corticosteroid-binding globulin (CBG), adrenocorticotropic hormone (ACTH), and luteneinizing hormone levels in rats. Whether this is due to ...

Interplay of the inflammatory and stress systems in a hepatic cell line : interactions between glucocorticoid receptor agonists and interleukin-6

Visser, Koch Smith, Carine Louw, Ann (HighWire Press, 2010-11)

The liver plays an important role in inflammation and stress by producing the acute phase proteins (APPs) required for resolution of inflammation as well as by delivering systemic glucose, through gluconeogenesis, required ...

Ligand-selective transactivation and transrepression via the glucocorticoid receptor : role of cofactor interaction

Ronacher, Katharina Hadley, Katie Avenant, Chanel Stubsrud, Elisabeth Simons, Jr. S. Stoney Louw, Ann Hapgood, Janet P. (Elsevier, 2009-02)

The mechanisms that determine ligand-selective transcriptional responses by the glucocorticoid receptor (GR) are not fully understood. Using a wide panel of GR ligands, we investigated the relationships between the potency ...

Research Articles (Biochemistry)

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