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Now showing items 1-5 of 5
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High molecular weight adiponectin levels are neither influenced by adiponectin polymorphisms nor associated with insulin resistance in mixed-ancestry hyperglycemic subjects from South Africa
(De Gruyter Open, 2016)Background: High molecular weight (HMW) adiponectin has antiatherogenic, antiinflammatory and antidiabetic properties and these effects have been linked to its effect on high density lipoprotein cholesterol (HDL-c). Single ... -
Genome-wide DNA methylation in mixed ancestry individuals with diabetes and prediabetes from South Africa
(Hindawi Publishing Corporation, 2016)Aims. To conduct a genome-wide DNA methylation in individuals with type 2 diabetes, individuals with prediabetes, and control mixed ancestry individuals from South Africa. Methods. We used peripheral blood to perform ... -
Effects of different missing data imputation techniques on the performance of undiagnosed diabetes risk prediction models in a mixed-ancestry population of South Africa
(Public Library of Science, 2016)Background: Imputation techniques used to handle missing data are based on the principle of replacement. It is widely advocated that multiple imputation is superior to other imputation methods, however studies have ... -
A century of trends in adult human height
(eLife Sciences Publications, 2016)ENGLISH SUMMARY : Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to ... -
Application of advanced molecular technology in the diagnosis and management of genetic disorders in South Africa
(Health & Medical Publishing Group, 2016)Background. Genetic testing has evolved from a niche speciality for diagnosis of rare disorders and carrier screening to subtyping of complex medical conditions for targeted treatment. Genes causing monogenic disorders are ...
