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Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa

Vergotine, Zelda; Yako, Yandiswa Y.; Kengne, Andre P.; Erasmus, Rajiv T.; Matsha, Tandi E. (BioMed Central, 2014-01)

Background: The peroxisome proliferator-activated receptor gamma (PPARG), Pro12Ala and the insulin receptor substrate (IRS1), Gly972Arg confer opposite effects on insulin resistance and type 2 diabetes mellitus (T2DM). We ...