Research Articles (Anatomical Pathology)

Hyperplastic polyp or sessile serrated lesion? the contribution of serial sections to reclassification

Jaravaza, Diana R.; Rigby, Jonathan M. (BMC (part of Springer Nature), 2020)

Background: The histological discrimination of hyperplastic polyps from sessile serrated lesions can be difficult. Sessile serrated lesions and hyperplastic polyps are types of serrated polyps which confer different ...

Incidence of Hodgkin lymphoma in HIV-positive and HIV-negative patients at a tertiary hospital in South Africa (2005 - 2016) and comparison with other African countries

Naidoo, N.; Abayomi, A.; Locketz, C.; Musaigwa, F.; Grewal, R. (Health & Medical Publishing Group, 2018-06-26)

Background. Hodgkin lymphoma (HL) is the most common non-AIDS-defining cancer in HIV-positive patients. Studies on South African (SA) populations have described the prevalence as 7 - 17% of all lymphomas, 8 - 27% of head ...

Fatal tumour pulmonary embolism

Masoud, Salim Rashid; Koegelenberg, Coenraad Frederik Nicolaas; Van Wyk, Abraham Christoffel; Allwood, Brian W. (Wiley Open Access, 2017)

A 30-year-old female with no significant past medical history was referred to our facility with sudden onset of shortness of breath. She had a low clinical probability for pulmonary thromboembolism and a computed ...

Colonic perineurioma (benign fibroblastic polyp) : case report and review of the literature

Van Wyk, Abraham Christoffel; Van Zyl, Hennie; Rigby, Jonathan (BioMed Central, 2018)

Background: Colorectal perineuriomas are uncommon benign mucosal-based proliferations of mesenchymal cells that express perineurial markers, often associated with colonic crypts displaying a serrated/hyperplastic ...

Exome sequencing in a family with luminal-type breast cancer underpinned by variation in the methylation pathway

Van der Merwe, Nicole; Peeters, Armand V.; Pienaar, Fredrieka M.; Bezuidenhout, Juanita; Van Rensburg, Susan J.; Kotze, Maritha J. (MDPI, 2017-02-22)

ENGLISH ABSTRACT: Panel-based next generation sequencing (NGS) is currently preferred over whole exome sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges caused by variants of uncertain ...

A biobank to support HIV malignancy research for sub-Saharan Africa

Schneider, Johann Wilhelm; Sanderson, Micheline; Geiger, Dieter; Nokta, Mostafa; Silver, Sylvia (Health & Medical Publishing Group, 2016)

Sub-Saharan Africa has one of the highest incidences of infection with HIV globally, but more people in this region are living longer owing to increased access to antiretroviral therapy. However, along with increased care ...

Histological and immunohistochemical evaluation of sentinel lymph nodes in breast cancer at a tertiary hospital in the Western Cape, South Africa

Van Zyl, Adri; Schneider, Johann W. (Health & Medical Publishing Group, 2016-04-19)

Background. Breast carcinoma remains the most prevalent cancer among women, with over 300 000 deaths annually worldwide. Axillary lymph node status is essential for the clinical staging of breast carcinoma and remains the ...

Non-allopathic adjuvant management of osteoarthritis by alkalinisation of the diet

Van Velden, David P.; Reuter, Helmuth; Kidd, Martin; Muller, F. Otto (AOSIS Publishing, 2015)

Background: Osteoarthritis (OA) is a chronic condition. Nonsteroidal anti-inflammatory drugs recommended for treatment have serious adverse effects. A compelling body of anecdotal evidence alerted the authors to the ...

The role of MKP-1 in the anti-proliferative effects of glucocorticoids in primary rat pre-osteoblasts

Sanderson, Micheline; Sadie-Van Gijsen, Hanel; Hough, Stephen; Ferris, William F. (Public Library of Science, 2015)

Glucocorticoid (GC)-induced osteoporosis has been attributed to a GC-induced suppression of pre-osteoblast proliferation. Our previous work identified a critical role for mitogen-activated protein kinase (MAPK) phosphatase-1 ...

MammaPrint Pre-screen Algorithm (MPA) reduces chemotherapy in patients with early-stage breast cancer

Grant, Kathleen A.; Apffelstaedt, Justus P.; Wright, Colleen A.; Myburgh, Ettienne; Pienaar, Rika; De Klerk, Manie; Kotze, Maritha J. (Health & Medical Publishing Group, 2013-07-03)

Background. Clinical and pathological parameters may overestimate the need for chemotherapy in patients with early-stage breast cancer. More accurate determination of the risk of distant recurrence is now possible with use ...

An evaluation of the diagnostic adequacy and immunocytochemistry of manual liquid-based smears in breast aspirates

Shibemba, A. L.; Wright, C. A.; Bezuidenhout, J.; Schubert, P. T. (Medpharm Publications, 2013)

The aim of this study was to determine if the Syner-Med®/Cell-Solutions® liquid-based cytology (LBC) technique would provide adequate diagnostic material when applied to breast fine-needle aspiration biopsy (FNAB) specimens ...

The quality of specimens obtained by fine-needle aspiration biopsy : does training make a difference?

Goedhals, Jacqueline; Thiart, Jacoretha; Joubert, Gina; Wright, Colleen (Medpharm Publications, 2012)

Background: The aim of this study was to determine the outcome of a one-hour training session on the correct technique of fine-needle aspiration biopsy (FNAB) by assessing adequacy of FNAB specimens received from clinicians ...

Exome sequencing combined with semantic discovery identifies strong disease-associated candidates in a single case of relapsing remitting multiple sclerosis

Jalali Sefid Dashti; Kotze, Maritha; Janse Van Rensburg, Susan; Christoffels, Alan; Gamieldien, Junaid (BioMed Central, 2012-10)

As known disease-associated variants identified through large cohort-based studies often explain only a small percentage of genetic risk in multifactorial disorders such as multiple sclerosis (MS), alternative methods ...

Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer’s disease

Kotze, Maritha J.; Van Rensburg, Susan J. (SpringerLink, 2012-04)

Chronic, multi-factorial conditions caused by a complex interaction between genetic and environmental risk factors frequently share common disease mechanisms, as evidenced by an overlap between genetic risk factors ...

Complex patterns of genomic admixture within Southern Africa

Petersen, Desiree C.; Libiger, Ondrej; Tindall, Elizabeth A.; Hardie, Rae-Anne; Hannick, Linda I.; Glashoff, Richard H.; Mukerji, Mitali; Indian Genome Variation Consortium; Fernandez, Pedro; Haacke, Wilfrid; Schork, Nicholas J.; Hayes, Vanessa M. (PLOS, 2013-03)

Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the ...