Clinical features and outcome in children admitted to a TB hospital in the Western Cape : the influence of HIV infection and drug resistance

dc.contributor.authorSoeters, M.
dc.contributor.authorDe Vries, Anne Martien
dc.contributor.authorKimpen, Jan L. L.
dc.contributor.authorDonald, Peter R.
dc.contributor.authorSchaaf, H. Simon
dc.identifier.citationSoeters, M, De Vries, AM, Kimpen, JLL. Donald, PR & Schaaf, HS 2005, 'Clinical features and outcome in children admitted to a TB hospital in the Western Cape - The influence of HIV infection and drug resistance', South African Medical Journal, vol. 95, no. 8, pp. 602-606.en_ZA
dc.description.abstractBackground. The Western Cape has a high incidence of tuberculosis (TB) and a rising prevalence of HIV infection. Children form 15-20% of this TB burden. Objective. To document the clinical features and outcome of TB among children admitted to a regional TB hospital. Method. A retrospective, descriptive study was undertaken of children under 15 years of age admitted to Brooklyn Hospital for Chest Diseases from January 2000 to December 2001. Demographic and clinical details of children were recorded routinely in a register that formed the basis of this review. Results. Two hundred and thirty-eight of the 250 children admitted had TB, of whom 120 (50.4%) were boys. The median age was 25 months. Reasons for admission were disease severity in 99 cases, social reasons in 36, and a combination in 103. Adult source cases were identified in 138 instances; 9 had drug-resistant TB, 31 drug-susceptible TB and in 98 cases susceptibility was unknown. TB was confirmed by culture in 119 children. Of 79 in whom susceptibility testing was done, 10 had isoniazid-resistant TB and 8 multidrug-resistant TB. HIV serology was positive in 43 of 138 children tested (31%). Previous antituberculosis treatment, severe malnutrition and weight under the 3rd percentile for age, a negative Mantoux test, and mortality were significantly more common in the HIV-infected children. Twenty-two of 41 previously negative Mantoux tests (< 5 mm induration) were positive on retesting. Conclusions. HIV infection is common in children with TB and malnutrition, and mortality in this group is high. Repeat Mantoux tests may show an increased number of positive results.en_ZA
dc.format.extent5 p.
dc.subjectTuberculostatic agentsen_ZA
dc.subjectAntibiotic resistanceen_ZA
dc.subjectAntibiotic sensitivityen_ZA
dc.subjectBacterium cultureen_ZA
dc.subjectBody weighten_ZA
dc.subjectChildhood mortalityen_ZA
dc.subjectComputer assisted tomographyen_ZA
dc.subjectDisease severityen_ZA
dc.subjectDisease transmissionen_ZA
dc.subjectDrug eruptionen_ZA
dc.subjectEnzyme linked immunosorbent assayen_ZA
dc.subjectExtrapulmonary tuberculosisen_ZA
dc.subjectHealth care facilitiesen_ZA
dc.subjectHospital admissionen_ZA
dc.subjectHuman immunodeficiency virusen_ZA
dc.subjectHuman immunodeficiency virus infectionen_ZA
dc.subjectLung tuberculosisen_ZA
dc.subjectMultidrug resistanceen_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectPolymerase chain reactionen_ZA
dc.subjectSputum smearen_ZA
dc.subjectThorax radiographyen_ZA
dc.subjectTuberculin testen_ZA
dc.subjectTuberculous meningitisen_ZA
dc.subjectTuberculosis, Multidrug-Resistanten_ZA
dc.subjectTuberculosis, Pulmonaryen_ZA
dc.subjectSeverity of Illness indexen_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectMicrobial Sensitivity Testsen_ZA
dc.subjectHospitals, Specialen_ZA
dc.subjectDeveloping countriesen_ZA
dc.subjectAIDS-related opportunistic infectionsen_ZA
dc.subjectAntitubercular agentsen_ZA
dc.subjectTuberculosis in children -- Hospital treament -- South Africa -- Western Capeen
dc.titleClinical features and outcome in children admitted to a TB hospital in the Western Cape : the influence of HIV infection and drug resistanceen_ZA

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