Clinical features and outcome in children admitted to a TB hospital in the Western Cape : the influence of HIV infection and drug resistance

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dc.contributor.author Soeters, M.
dc.contributor.author De Vries, Anne Martien
dc.contributor.author Kimpen, Jan L. L.
dc.contributor.author Donald, Peter R.
dc.contributor.author Schaaf, H. Simon
dc.date.accessioned 2010-12-21T14:01:46Z
dc.date.available 2010-12-21T14:01:46Z
dc.date.issued 2005-08
dc.identifier.citation Soeters, M, De Vries, AM, Kimpen, JLL. Donald, PR & Schaaf, HS 2005, 'Clinical features and outcome in children admitted to a TB hospital in the Western Cape - The influence of HIV infection and drug resistance', South African Medical Journal, vol. 95, no. 8, pp. 602-606. en_ZA
dc.identifier.issn 0256-9574
dc.identifier.uri http://hdl.handle.net/10019.1/5499
dc.description.abstract Background. The Western Cape has a high incidence of tuberculosis (TB) and a rising prevalence of HIV infection. Children form 15-20% of this TB burden. Objective. To document the clinical features and outcome of TB among children admitted to a regional TB hospital. Method. A retrospective, descriptive study was undertaken of children under 15 years of age admitted to Brooklyn Hospital for Chest Diseases from January 2000 to December 2001. Demographic and clinical details of children were recorded routinely in a register that formed the basis of this review. Results. Two hundred and thirty-eight of the 250 children admitted had TB, of whom 120 (50.4%) were boys. The median age was 25 months. Reasons for admission were disease severity in 99 cases, social reasons in 36, and a combination in 103. Adult source cases were identified in 138 instances; 9 had drug-resistant TB, 31 drug-susceptible TB and in 98 cases susceptibility was unknown. TB was confirmed by culture in 119 children. Of 79 in whom susceptibility testing was done, 10 had isoniazid-resistant TB and 8 multidrug-resistant TB. HIV serology was positive in 43 of 138 children tested (31%). Previous antituberculosis treatment, severe malnutrition and weight under the 3rd percentile for age, a negative Mantoux test, and mortality were significantly more common in the HIV-infected children. Twenty-two of 41 previously negative Mantoux tests (< 5 mm induration) were positive on retesting. Conclusions. HIV infection is common in children with TB and malnutrition, and mortality in this group is high. Repeat Mantoux tests may show an increased number of positive results. en_ZA
dc.format.extent 5 p.
dc.language.iso en_US en_ZA
dc.publisher SAMJ en_ZA
dc.subject Ethambutol en_ZA
dc.subject Ethionamide en_ZA
dc.subject Isoniazid en_ZA
dc.subject Pyrazinamide en_ZA
dc.subject Rifampicin en_ZA
dc.subject Tuberculin en_ZA
dc.subject Tuberculostatic agents en_ZA
dc.subject Adolescents en_ZA
dc.subject Antibiotic resistance en_ZA
dc.subject Antibiotic sensitivity en_ZA
dc.subject Bacterium culture en_ZA
dc.subject Body weight en_ZA
dc.subject Childhood mortality en_ZA
dc.subject Comorbidity en_ZA
dc.subject Computer assisted tomography en_ZA
dc.subject Disease severity en_ZA
dc.subject Disease transmission en_ZA
dc.subject Drug eruption en_ZA
dc.subject Enzyme linked immunosorbent assay en_ZA
dc.subject Extrapulmonary tuberculosis en_ZA
dc.subject Health care facilities en_ZA
dc.subject Hospital admission en_ZA
dc.subject Human immunodeficiency virus en_ZA
dc.subject Human immunodeficiency virus infection en_ZA
dc.subject Jaundice en_ZA
dc.subject Lung tuberculosis en_ZA
dc.subject Malnutrition en_ZA
dc.subject Multidrug resistance en_ZA
dc.subject Mycobacterium tuberculosis en_ZA
dc.subject Polymerase chain reaction en_ZA
dc.subject Serology en_ZA
dc.subject Sputum smear en_ZA
dc.subject Thorax radiography en_ZA
dc.subject Tuberculin test en_ZA
dc.subject Tuberculosis en_ZA
dc.subject Tuberculous meningitis en_ZA
dc.subject Tuberculosis, Multidrug-Resistant en_ZA
dc.subject Tuberculosis, Pulmonary en_ZA
dc.subject Severity of Illness index en_ZA
dc.subject Mycobacterium tuberculosis en_ZA
dc.subject Microbial Sensitivity Tests en_ZA
dc.subject Hospitals, Special en_ZA
dc.subject Developing countries en_ZA
dc.subject AIDS-related opportunistic infections en_ZA
dc.subject Antitubercular agents en_ZA
dc.subject Tuberculosis in children -- Hospital treament -- South Africa -- Western Cape en
dc.title Clinical features and outcome in children admitted to a TB hospital in the Western Cape : the influence of HIV infection and drug resistance en_ZA
dc.type Article en_ZA


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