Browsing Research Articles (Genetics) by Title

Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis : a case-control association study

Moller, Marlo Nebel, Almut Van Helden, Paul D. Schreiber, Stefan Hoal, Eileen G. (BioMed Central, 2010-06)

Background: Interferon gamma is a major macrophage-activating cytokine during infection with Mycobacterium tuberculosis, the causative pathogen of tuberculosis, and its role has been well established in animal models and ...

Characterization of the genetic variation present in CYP3A4 in three South African populations

Drogemoller, Britt Plummer, Marieth Korkie, Lundi Agenbag, Gloudi Dunaiski, Anke Niehaus, Dana Koen, Liezl Gebhardt, Stefan Schneider, Nicol Olckers, Antonel Wright, Galen Warnich, Louise (Frontiers, 2013-02)

The CYP3A4 enzyme is the most abundant human cytochrome P450 (CYP) and is regarded as the most important enzyme involved in drug metabolism. Inter-individual and inter-population variability in gene expression and enzyme ...

Chromosome 22q11 in a Xhosa schizophrenia population

Koen, Liezl Niehaus, Dana J. H. Wright, Galen Warnich, Louise De Jong, Greetje Emsley, Robin A. Mall, Sumaya (Health and Medical Publishing Group (HMPG), 2012-03)

Chromosome 22q11 aberrations substantially increase the risk for developing schizophrenia. Although micro-deletions in this region have been extensively investigated in different populations across the world, little is ...

Complete nucleotide sequence of a South African isolate of grapevine fanleaf virus and its associated satellite RNA

Lamprecht, Renate L. Spaltman, Monique Stephan, Dirk Wetzel, Thierry Burger, Johan T. (MDPI, 2013-07)

The complete sequences of RNA1, RNA2 and satellite RNA have been determined for a South African isolate of Grapevine fanleaf virus (GFLV-SACH44). The two RNAs of GFLV-SACH44 are 7,341 nucleotides (nt) and 3,816 nt in length, ...

GSA-PCA : gene set generation by principal component analysis of the Laplacian matrix of a metabolic network

Jacobson, Dan Emerton, Guy (BioMed Central, 2012-08)

Abstract Background Gene Set Analysis (GSA) has proven to be a useful approach to microarray analysis. However, most of the method development for GSA has focused on the statistical tests ...

Introduction of the AmpliChip CYP450 Test to a South African cohort : a platform comparative prospective cohort study

Dodgen, Tyren M. Hochfeld, Warren E. Fickl, Heidi Asfaha, Sahle M. Durandt, Chrisna Rheeder, Paul Drogemoller, Britt I. Wright, Galen E. B. Warnich, Louise Labuschagne, Christiaan D. J. Van Schalkwyk, Antoinette Gaedigk, Andrea Pepper, Michael S. (BioMed Central, 2013-01)

Abstract Background Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to inter-individual variability ...

Isolation and validation of microsatellite markers from a depleted South African sciaenid species, the dusky kob (Argyrosomus japonicus), by means of the FIASCO/454 approach

Mirimin, L. Ruiz Guajardo, J. C. Vervalle, J. Bester-Van der Merwe, Aletta Kerwath, S. Macey, B. Bloomer, P. Roodt-Wilding, R. (Springer Verlag, 2013-04)

The dusky kob (Argyrosomus japonicus) is a large, estuarine-dependent sciaenid fish that has been severely depleted in South African waters and that, in recent years, has received considerable attention from the local fish ...

Next-generation sequencing of cervical DNA detects human papillomavirus types not detected by commercial kits

Meiring, Tracy L Salimo, Anna T Coetzee, Beatrix Maree, Hans J Moodley, Jennifer Hitzeroth, Inga I Freeborough, Michael-John Rybicki, Ed P. Williamson, Anna-Lise (BioMed Central, 2012-08)

Abstract Background Human papillomavirus (HPV) is the aetiological agent for cervical cancer and genital warts. Concurrent HPV and HIV infection in the South African population is high. HIV ...

An observational audit of pain scores post-orthopaedic surgery at a level two state hospital in Cape Town

Hauser, Neil David Dyer, Robert Pepler, Pieter Theo Rolfe, Deborah A. (MedPharm Publications, 2014-05)

Objectives: The aim was to determine whether postoperative pain is satisfactorily controlled in patients undergoing orthopaedic surgery at a level two state hospital in Cape Town. Design: Two observational audits were ...

Pharmacogenomic research in South Africa : lessons learned and future opportunities in the rainbow nation

Warnich, Louise Drogemoller, Britt I. Pepper, Michael S. Dandara, Collet Wright, Galen E.B. (Bentham Science, 2011-09)

ENGLISH ABSTRACT: South Africa, like many other developing countries, stands to benefit from novel diagnostics and drugs developed by pharmacogenomics guidance due to high prevalence of disease burden in the region. This ...

Predicting mortality and length-of-stay for neonatal admissions to private hospital neonatal intensive care units : a Southern African retrospective study

Pepler, Pieter Theo Uys, Daniel Wilhelm Nel, Daniel Gerhardus (Faculty of Medicine, Makerere University, 2012-06)

Objectives: To predict neonatal mortality and length of stay (LOS) from readily available perinatal data for neonatal intensive care unit (NICU) admissions in Southern African private hospitals. Methods: Retrospective ...

Real-time RT-PCR high resolution melting curve analysis and multiplex RT-PCR to detect and differentiate grapevine leafroll-associated associated virus 3 variant groups I, II, III and VI

Bester, Rachelle Jooste, Anna E. C. Maree, Hans J. Burger, Johan T. (BioMed Central, 2012-09)

Abstract Background Grapevine leafroll-associated virus 3 (GLRaV-3) is the main contributing agent of leafroll disease worldwide. Four of the six GLRaV-3 variant groups known have been found ...

Transcriptome characterization of the South African abalone Haliotis midae using sequencing-by-synthesis

Franchini, Paolo Van der Merwe, Mathilde Roodt-Wilding, Rouvay (BioMed Central, 2011-03)

Abstract. Background. Worldwide, the genus Haliotis is represented by 56 extant species and several of these are commercially cultured. Among the six abalone species found in South Africa, Haliotis midae is the only ...

Transcriptome-wide single nucleotide polymorphisms (SNPs) for Abalone (Haliotis midae) : validation and application using GoldenGate medium-throughput genotyping assays

Bester-Van Der Merwe, Aletta Blaauw, Sonja Du Plessis, Jana Roodt-Wilding, Rouvay (MDPI, 2013-09)

Haliotis midae is one of the most valuable commercial abalone species in the world, but is highly vulnerable, due to exploitation, habitat destruction and predation. In order to preserve wild and cultured stocks, genetic ...

Visualization of plant viral suppressor silencing activity in intact leaf lamina by quantitative fluorescent imaging

Stephan, Dirk Slabber, Coba George, Gavin Ninov, Victor Francis, Kevin P. Burger, Johan T. (BioMed Central Ltd., 2011-08)

ABSTRACT: BACKGROUND: Transient expression of proteins in plants has become a favoured method over the production of stably transformed plants because, in addition to enabling high protein yields, it is both fast and easy ...

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