Browsing Research Articles (Genetics) by Title
Now showing items 1-20 of 20
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Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis : a case-control association study
(BioMed Central, 2010-06)Background: Interferon gamma is a major macrophage-activating cytokine during infection with Mycobacterium tuberculosis, the causative pathogen of tuberculosis, and its role has been well established in animal models and ...
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Characterization of the genetic variation present in CYP3A4 in three South African populations
(Frontiers, 2013-02)The CYP3A4 enzyme is the most abundant human cytochrome P450 (CYP) and is regarded as the most important enzyme involved in drug metabolism. Inter-individual and inter-population variability in gene expression and enzyme ...
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Chromosome 22q11 in a Xhosa schizophrenia population
(Health and Medical Publishing Group (HMPG), 2012-03)Chromosome 22q11 aberrations substantially increase the risk for developing schizophrenia. Although micro-deletions in this region have been extensively investigated in different populations across the world, little is ...
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Complete nucleotide sequence of a South African isolate of grapevine fanleaf virus and its associated satellite RNA
(MDPI, 2013-07)The complete sequences of RNA1, RNA2 and satellite RNA have been determined for a South African isolate of Grapevine fanleaf virus (GFLV-SACH44). The two RNAs of GFLV-SACH44 are 7,341 nucleotides (nt) and 3,816 nt in length, ...
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Diverse exopolysaccharide producing bacteria isolated from milled sugarcane : implications for cane spoilage and sucrose yield
(Public Library of Science, 2015)Bacterial deterioration of sugarcane during harvesting and processing is correlated with significant loss of sucrose yield and the accumulation of bacterial polysaccharides. Dextran, a homoglucan produced by Leuconostoc ...
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Evidence for water deficit-induced mass increases of raffinose family oligosaccharides (RFOs) in the leaves of three Craterostigma resurrection plant species
(Frontiers Media, 2015-07)The leaves of the resurrection plant Craterostigma plantagineum accumulate sucrose during dehydration, via a conversion from the unusual C8 ketose-sugar 2-octulose. However, raffinose family oligosaccharides (RFOs) have ...
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Extending the sRNAome of Apple by next-generation sequencing
(Public Library of Science, 2014-04)The global importance of apple as a fruit crop necessitates investigations into molecular aspects of the processes that influence fruit quality and yield, including plant development, fruit ripening and disease resistance. ...
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GSA-PCA : gene set generation by principal component analysis of the Laplacian matrix of a metabolic network
(BioMed Central, 2012-08)Abstract Background Gene Set Analysis (GSA) has proven to be a useful approach to microarray analysis. However, most of the method development for GSA has focused on the statistical tests ...
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Introduction of the AmpliChip CYP450 Test to a South African cohort : a platform comparative prospective cohort study
(BioMed Central, 2013-01)Abstract Background Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to inter-individual variability ...
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Isolation and validation of microsatellite markers from a depleted South African sciaenid species, the dusky kob (Argyrosomus japonicus), by means of the FIASCO/454 approach
(Springer Verlag, 2013-04)The dusky kob (Argyrosomus japonicus) is a large, estuarine-dependent sciaenid fish that has been severely depleted in South African waters and that, in recent years, has received considerable attention from the local fish ...
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Next-generation sequencing for virus detection : covering all the bases
(BioMed Central, 2016-06)Background: The use of next-generation sequencing has become an established method for virus detection. Efficient study design for accurate detection relies on the optimal amount of data representing a significant portion ...
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Next-generation sequencing of cervical DNA detects human papillomavirus types not detected by commercial kits
(BioMed Central, 2012-08)Abstract Background Human papillomavirus (HPV) is the aetiological agent for cervical cancer and genital warts. Concurrent HPV and HIV infection in the South African population is high. HIV ...
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An observational audit of pain scores post-orthopaedic surgery at a level two state hospital in Cape Town
(MedPharm Publications, 2014-05)Objectives: The aim was to determine whether postoperative pain is satisfactorily controlled in patients undergoing orthopaedic surgery at a level two state hospital in Cape Town. Design: Two observational audits were ...
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Pharmacogenomic research in South Africa : lessons learned and future opportunities in the rainbow nation
(Bentham Science, 2011-09)ENGLISH ABSTRACT: South Africa, like many other developing countries, stands to benefit from novel diagnostics and drugs developed by pharmacogenomics guidance due to high prevalence of disease burden in the region. This ...
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Phylogenomic analysis reveals deep divergence and recombination in an economically important grapevine virus.
(Public Library of Science, 2015)The evolutionary history of the exclusively grapevine (Vitis spp.) infecting, grapevine leafroll-associated virus 3 (GLRaV-3) has not been studied extensively, partly due to limited available sequence data. In this study ...
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Predicting mortality and length-of-stay for neonatal admissions to private hospital neonatal intensive care units : a Southern African retrospective study
(Faculty of Medicine, Makerere University, 2012-06)Objectives: To predict neonatal mortality and length of stay (LOS) from readily available perinatal data for neonatal intensive care unit (NICU) admissions in Southern African private hospitals. Methods: Retrospective ...
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Real-time RT-PCR high resolution melting curve analysis and multiplex RT-PCR to detect and differentiate grapevine leafroll-associated associated virus 3 variant groups I, II, III and VI
(BioMed Central, 2012-09)Abstract Background Grapevine leafroll-associated virus 3 (GLRaV-3) is the main contributing agent of leafroll disease worldwide. Four of the six GLRaV-3 variant groups known have been found ...
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Transcriptome characterization of the South African abalone Haliotis midae using sequencing-by-synthesis
(BioMed Central, 2011-03)Abstract. Background. Worldwide, the genus Haliotis is represented by 56 extant species and several of these are commercially cultured. Among the six abalone species found in South Africa, Haliotis midae is the only ...
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Transcriptome-wide single nucleotide polymorphisms (SNPs) for Abalone (Haliotis midae) : validation and application using GoldenGate medium-throughput genotyping assays
(MDPI, 2013-09)Haliotis midae is one of the most valuable commercial abalone species in the world, but is highly vulnerable, due to exploitation, habitat destruction and predation. In order to preserve wild and cultured stocks, genetic ...
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Visualization of plant viral suppressor silencing activity in intact leaf lamina by quantitative fluorescent imaging
(BioMed Central Ltd., 2011-08)ABSTRACT: BACKGROUND: Transient expression of proteins in plants has become a favoured method over the production of stably transformed plants because, in addition to enabling high protein yields, it is both fast and easy ...
