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The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

Womersley, Jacqueline S.; Clauss, Lara B.; Varathan, Olivette; Engelbrecht, Susan; Hemmings, Sian M. J.; Seedat, Soraya; Spies, Georgina (BMC (part of Springer Nature), 2019-12-27)

Objective: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were ...
The relationship between potentially traumatic or stressful events, HIV infection and neurocognitive impairment (NCI) : a systematic review of observational epidemiological studies

Spies, G.; Mall, S.; Wiele, H.; Masile, L.; Konkiewit, E. Castelon; Seedat, S. (Taylor & Francis, 2020)

Background: HIV/AIDS and potentially traumatic events (PTEs) or stressful life events (SLEs) and/or PTSD are independently associated with neurocognitive impairment (NCI). Literature suggests that HIV and PTE/SLE exposure ...