• Participants’ perspectives of weekly telephonic mood monitoring in South Africa : a feasibility study 

      Van der Watt, A. S. J.; Roos, T.; Beyer, C.; Seedat, S. (BioMed Central, 2018-02-22)
      Background: Mood and anxiety disorders have a high lifetime prevalence, and their chronicity adds to the management burden of already scarce and strained mental health care resources, particularly in developing countries. ...
    • Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture 

      Davis, Lea K.; Yu, Dongmei; Keenan, Clare L.; Gamazon, Eric R.; Konkashbaev, Anuar I.; Derks, Eske M.; Neale, Benjamin M.; Yang, Jian; Lee, S. Hong; Evans, Patrick; Barr, Cathy L.; Bellodi, Laura; Benarroch, Fortu; Berrio, Gabriel Bedoya; Bienvenu, Oscar J.; Bloch, Michael H.; Blom, Rianne M.; Bruun, Ruth D.; Budman, Cathy L.; Camarena, Beatriz; Campbell, Desmond; Cappi, Carolina; Silgado, Julio C. Cardona; Cath, Danielle C.; Cavallini, Maria C.; Chavira, Denise A.; Chouinard, Sylvain; Conti, David. V.; Cook, Edwin H.; Coric, Vladimir; Cullen, Bernadette A.; Deforce, Dieter; Delorme, Richard; Dion, Yves; Edlund, Christopher K.; Egberts, Karin; Falkai, Peter; Fernandez, Thomas V.; Gallagher, Patience J.; Garrido, Helena; Geller, Daniel; Girard, Simon L.; Grabe, Hans J.; Grados, Marco A.; Greenberg, Benjamin D.; Gross-Tsur, Varda; Haddad, Stephen; Heiman, Gary A.; Hemmings, Sian M. J.; Hounie, Ana G.; Illmann, Cornelia; Jankovic, Joseph; Jenike, Michael A.; Kennedy, James L.; King, Robert A.; Kremeyer, Barbara; Kurlan, Roger; Lanzagorta, Nuria; Leboyer, Marion; Leckman, James F.; Lennertz, Leonhard; Liu, Chunyu; Lochner, Christine; Lowe, Thomas L.; Macciardi, Fabio; McCracken, James T.; McGrath, Lauren M.; Mesa Restrepo, Sandra C.; Moessner, Rainald; Morgan, Jubel; Muller, Heike; Murphy, Dennis L.; Naarden, Allan L.; Ochoa, William Cornejo; Ophoff, Roel A.; Osiecki, Lisa; Pakstis, Andrew J.; Pato, Michele T.; Pato, Carlos N.; Piacentini, John; Pittenger, Christopher; Pollak, Yehuda; Rauch, Scott L.; Renner, Tobias J.; Reus, Victor I.; Richter, Margaret A.; Riddle, Mark A.; Robertson, Mary M.; Romero, Roxana; Rosario, Maria C.; Rosenberg, David; Rouleau, Guy A.; Ruhrmann, Stephan; Ruiz-Linares, Andres; Sampaio, Aline S.; Samuels, Jack; Sandor, Paul; Sheppard, Brooke; Singer, Harvey S.; Smit, Jan H.; Stein, Dan J.; Strengman, E.; Tischfield, Jay A.; Valencia Duarte, Ana V.; Vallada, Homero; Van Nieuwerburgh, Filip; Veenstra-VanderWeele, Jeremy; Walitza, Susanne; Wang, Ying; Wendland, Jens R.; Westenberg, Herman G. M.; Shugart, Yin Yao; Miguel, Euripedes C.; McMahon, William; Wagner, Michael; Nicolini, Humberto; Posthuma, Danielle; Hanna, Gregory L.; Heutnik, Peter; Denys, Damiaan; Arnold, Paul D.; Oostra, Ben A.; Nestadt, Gerald; Freimer, Nelson B.; Pauls, David L.; Wray, Naomi R.; Stewart, S. Evelyn; Mathews, Carol A.; Knowles, James A.; Cox, Nancy J.; Shcarf, Jeremiah M. (PLoS, 2013-10)
      The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated ...
    • Patterns of substance use in South Africa : results from the South African Stress and Health study 

      Van Heerden, Margaretha S.; Grimsrud, Anna T.; Seedat, Soraya; Myer, Landon; Williams, David R.; Stein, Dan J. (Health and Medical Publishing Group (HMPG), 2009)
      Background. There are limited data on substance use in South Africa. We describe patterns of substance use based on recent, nationally representative data. Methods. Data were derived from the 2002-2004 South African Stress ...
    • Perceived discrimination and mental health disorders : the South African Stress and Health study (SASH) 

      Moomal, Hashim; Jackson, Pamela B.; Stein, Dan J.; Herman, Allen; Myer, Landon; Seedat, Soraya; Madela-Mntla, Edith; Williams, D. R. (Health and Medical Publishing Group (HMPG), 2009)
      Objectives. To describe the demographic correlates of perceived discrimination and explore the association between perceived discrimination and psychiatric disorders. Design. A national household survey was conducted between ...
    • Perceptions of alcohol use in the context of HIV treatment : a qualitative study 

      Madhombiro, Munyaradzi; Marimbe-Dube, Bazondlile; Dube, Michelle; Kaiyo-Utete, Malinda; Paradzai, Angeline; Chibanda, Dixon; Rusakaniko, Simbarashe; Van Der Watt, A. S. J.; Seedat, Soraya (Dove Medical Press, 2018)
      Background: Alcohol use is associated with poor HIV treatment outcomes. This study aimed to understand patients’ perceptions of the impact of alcohol use in the context of HIV care. Methods: The study design was a descriptive ...
    • Perpetration of gross human rights violations in South Africa : association with psychiatric disorders 

      Stein, Dan J.; Williams, Stacey L.; Jackson, Pamela B.; Seedat, Soraya; Myer, Landon; Herman, Allen; Williams, David R. (Health and Medical Publishing Group (HMPG), 2009)
      Background. A nationally representative study of psychiatric disorders in South Africa provided an opportunity to study the association between perpetration of human rights violations (HRVs) during apartheid and psychiatric ...
    • Pharmacological challenge with a serotonin 1D agonist in alcohol dependence 

      Vythilingum, Bavanisha; Hugo, Charmaine J.; Maritz, J. Stefan; Pienaar, Willie P.; Stein, Dan J. (BioMed Central, 2005-08)
      Background: Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low serotonin ...
    • Pharmacotherapy for post-traumatic stress disorder : a systematic review and meta-analysis 

      Ipser, Jonathan; Seedat, Soraya; Stein, Dan J. (Health & Medical Publishing Group, 2006-10)
      Background. Post-traumatic stress disorder (PTSD) is a prevalent and disabling condition. Evidence that PTSD is characterised by specific psychobiological dysfunctions has contributed to a growing interest in use of ...
    • Pica and the obsessive-compulsive spectrum disorders 

      Stein, D. J.; Bouwer, C.; Van Heerden, B. (Health & Medical Publishing Group, 1996)
      Background. The concept of a spectrum of obsessive-compulsive related disorders may have clinical and research heuristic value in the approach to disorders similar to obsessive-compulsive disorder (OCD) in respect of ...
    • A pilot and feasibility randomised controlled study of prolonged exposure treatment and supportive counselling for post-traumatic stress disorder in adolescents : a third world, task-shifting, community-based sample 

      Rossouw, Jaco; Yadin, Elna; Alexander, Debra; Mbanga, Irene; Jacobs, Tracy; Seedat, Soraya (BioMed Central, 2016-11-17)
      ENGLISH SUMMARY : Background: There is a dearth of empirical evidence on the effectiveness of pharmacological and nonpharmacological treatments for adolescents with post-traumatic stress disorder (PTSD) in developing country ...
    • Placebo controls in clinical trials : concerns about use in relapse prevention studies in schizophrenia 

      Emsley, Robin A.; Turoff, Sarah; Fleischhacker, W. Wolfgang; Galderisi, Silvana; Halpern, Lisa J.; McEvoy, Joseph P.; Schooler, Nina R. (BMJ Publishing Group, 2016)
      ENGLISH SUMMARY : The use of placebos in clinical trials has major policy implications for ethical conduct across all of medicine and is relevant to clinicians, patients, drug development, and regulatory agencies. This ...
    • Post-menopausal panic disorder 

      Stein, D. J.; Bouwer, C. (Health & Medical Publishing Group, 1996)
      [No abstract available]
    • Post-traumatic stress disorder 

      Seedat, Soraya (AOSIS Publishing, 2013-08-30)
      ENGLISH SUMMARY : Post-traumatic stress disorder (PTSD) is among the most prevalentanxiety disorders, both in terms of lifetime and 12-month prevalencerates documented in epidemiological studies worldwide.
    • The potential role of regulatory genes (DNMT3A, HDAC5, and HDAC9) in antipsychotic treatment response in South African schizophrenia patients 

      O’Connell, Kevin Sean; McGregor, Nathaniel Wade; Emsley, Robin A.; Seedat, Soraya; Warnich, Louise (Frontiers Media, 2019-10-07)
      ENGLISH ABSTRACT: Despite advances in pharmacogenetics, the majority of heritability for treatment response cannot be explained by common variation, suggesting that factors such as epigenetics may play a key role. Regulatory ...
    • Prevalence and correlates of non-medical stimulants and related drug use in a sample of South African undergraduate medical students 

      Retief, Mari; Verster, Chris (AOSIS Publishing, 2016)
      Background: The non-medical use of prescription psychostimulants or cognitive-enhancing substances among healthy college students is a growing concern. This use appears to be particularly high among medical students. To ...
    • Prevalence and correlates of probable posttraumatic stress disorder and common mental disorders in a population with a high prevalence of HIV in Zimbabwe 

      Verhey, R.; Gibson, L.; Brakarsh, J.; Chibanda, D.; Seedat, S. (Taylor & Francis Open, 2018)
      Background: We investigated the prevalence of and factors associated with post-traumatic stress disorder (PTSD) and common mental disorders (CMDs), which include depression and anxiety disorders, in a setting with a ...
    • Prevalence and predictors of problematic alcohol use, risky sexual practices and other negative consequences associated with alcohol use among safety and security employees in the Western Cape, South Africa 

      Burnhams, Nadine Harker; Parry, Charles; Laubscher, Ria; London, Leslie (BioMed Central, 2014-03-04)
      Introduction: Harmful alcohol use can compromise worker health and productivity. Persons employed in safetysensitive occupations are particularly vulnerable to hazardous alcohol use and its associated risks. This study ...
    • The prevalence of compassion fatigue and burnout among healthcare professionals in intensive care units : a systematic review 

      Van Mol, Margo M. C.; Kompanje, Erwin J. O.; Benoit, Dominique D.; Bakker, Jan; Nijkamp, Marjan D. (Public Library of Science, 2015)
      Background: Working in the stressful environment of the Intensive Care Unit (ICU) is an emotionally charged challenge that might affect the emotional stability of medical staff. The quality of care for ICU patients and ...
    • Prevalence of obsessive compulsive disorder in first- and multi-episode male patients with schizophrenia-spectrum disorders 

      Koen, L.; Oosthuizen, P. P.; Niehaus, D. J. H.; Emsley, R. A.; Muller, J. E.; Stein, D. J.; Keyter, N.; Lochner, C.; Seedat, S. (Health & Medical Publishing Group, 2003)
      Studies suggest that obsessive compulsive disorder (OCD) is a prevalent disorder (7.8 - 31.7%) in patients with schizophrenia and first-episode psychosis.1,2 Despite the varied study designs that have been employed, ...
    • Private practice-driven research 

      Mashaphu, Sibongile; Chiliza, Bonginkosi (Health & Medical Publishing Group, 2016)
      ENGLISH SUMMARY : No abstract available.