• The nature of relapse in schizophrenia 

      Emsley, Robin; Chiliza, Bonginkosi; Asmal, Laila; Harvey, Brian, H. (BioMed Cenral, 2013-02)
      Background Multiple relapses characterise the course of illness in most patients with schizophrenia, yet the nature of these episodes has not been extensively researched and clinicians may not always be aware of important ...
    • Needs-based gap analysis for service transformation in the Eastern Cape 

      Sukeri, K.; Alonso-Betancourt, O.; Emsley, R. (AOSIS Publishing, 2015)
      Objectives. Part I of this research article presents a needs-based analysis for the management of schizophrenia, bipolar mood disorder and major depression for the Eastern Cape (EC) Province, South Africa. This part of the ...
    • Neonatal septicaemia : prevalence and antimicrobial susceptibility patterns of common pathogens at Princess Marina Hospital, Botswana 

      Mudzikati, Lydia; Dramowski, Angela (Medpharm Publications, 2015)
      Background: Septicaemia is the third most common cause of neonatal death after prematurity and birth asphyxia. The prevalence of neonatal sepsis and the spectrum of causative microorganisms fluctuates over time, thus ...
    • Neurological ageing factors : neurobiology of ageing and prevention of dementia 

      Potocnik, Felix C. V.; Janse van Rensburg, Susan; Bouwens, Christianne (Health & Medical Publishing Group, 2005-06)
      By the year 2000 the total human population passed the 6 billion mark. It is estimated to peak at 9 billion around 2070 before declining to 8.4 billion at the end of the century. The decline will largely be due to reduced ...
    • Neurological soft signs, spontaneous and treatment emergent extrapyramidal syndromes in Black Africans with first episode schizophrenia 

      Ojagbemi, Akin; Chiliza, Bonga; Bello, Toyin; Asmal, Laila; Esan, Oluyomi; Emsley, Robin A.; Gureje, Oye (Frontiers Media, 2018)
      Background: Very little is known about the relationship between spontaneous and treatment-induced motor syndromes in Africans with first episode schizophrenia. Objective: We investigated the association between spontaneous ...
    • The new psychiatry 

      Emsley, R. (Health & Medical Publishing Group, 1993)
      Doctors who qualified a decade or more ago are likely to be experiencing difficulties in keeping up with the changes taking place in the field of psychiatry, and may be surprised to see it assuming an increasingly ...
    • The new-generation antipsychotics - integrating the neuropathology and pharmacology of schizophrenia 

      Harvey, Brian H.; Stein, Dan J.; Emsley, Robin A. (Health & Medical Publishing Group, 1999)
      Despite a well-established role for dopamine (DA) in the neuropathology of schizophrenia, and the evidence of a hyperdopaminergic state in the schizophrenic brain, many questions still remain. Typical agents acting ...
    • Obsessive compulsive disorder 

      Stein, D. J. (AOSIS, 2013)
      This guideline focuses on the pharmacotherapy of obsessivecompulsive disorder (OCD). OCD is characterised by obsessions and compulsions. A number of other disorders are also characterised by repetitive thoughts and rituals ...
    • Obsessive compulsive disorder : prevalence in Xhosa-speaking schizophrenia patients 

      Niehaus, D. J. H.; Koen, L.; Muller, J.; Laurent, C.; Stein, D. J.; Lochner, C.; Seedat, S.; Mbanga, I.; Deleuze, J.-F.; Mallet, J.; Emsley, R. A. (Health & Medical Publishing Group, 2005)
      Obsessive compulsive disorder (OCD) has been reported in up to 31% of schizophrenia sufferers. This study evaluated the presence of OCD in a Xhosa-speaking schizophrenia group. Xhosa patients (N = 509, including 100 sibships) ...
    • Obsessive-compulsive disorder and trichotillomania : a phenomenological comparison 

      Lochner, Christine; Seedat, Soraya; Du Toit, Pieter L.; Nel, Daniel G.; Niehaus, Dana J. H.; Sandler, Robin; Stein, Dan J. (BioMed Central, 2005-01)
      Background: Similarities between obsessive-compulsive disorder (OCD) and trichotillomania (TTM) have been widely recognized. Nevertheless, there is evidence of important differences between these two disorders. Some authors ...
    • Obsessive-compulsive disorder in black South Africans - A case series 

      Gangdev, P. S.; Stein, D. J.; Ruzibiza, J. B. (Health & Medical Publishing Group, 1996)
      Background. Obsessive-compulsive disorder (OCD) has been shown to be highly prevalent in both developing and developed countries. Nevertheless, data on OCD in blacks, and black South Africans in particular, are limited. ...
    • Occupation and schizophrenia in a Xhosa population - A variant of the social drift theory? 

      Brink, Sandra; Niehaus, Dana J. H.; Oosthuizen, Piet; Muller, Jacqueline; Koen, Liezl (Health & Medical Publishing Group, 2004)
      ENGLISH SUMMARY : no abstract available.
    • Olfactory reference syndrome in DSM-V 

      Flegar, S. J.; Vythilingum, B.; Stein, D. J.; Lochner, C. (Health and Medical Publishing Group (HMPG), 2009-09)
      To the Editor: We read with interest Dr A Lawrence’s recent SAMJ case report of a young man who presented with persistent preoccupation with personal body odour in the absence of any physical abnormalities
    • Once-monthly paliperidone palmitate in early stage schizophrenia – a retrospective, non-interventional 1-year study of patients with newly diagnosed schizophrenia 

      Emsley, Robin A.; Hargarter, Ludger; Bergmans, Paul; Uglesic, Boran; Sengul, Abdullah Cem; Petralia, Antonino; Khannanova, Angelina; Cherubin, Pierre; Schreiner, Andreas (Dove Medical Press, 2017)
      Background: Long-acting antipsychotic therapy may be best suited for patients in the early stage of schizophrenia, when the most can be done before disease progression associated with poor adherence occurs. We explored the ...
    • Outcomes of adult heroin users v. abstinent users four years after presenting for heroin detoxification treatment 

      Khan, Zureida; Cloete, Karen Jacqueline; Harvey, Justin; Weich, Lize (AOSIS Publishing, 2014-08)
      Background. There are no studies in South Africa (SA) on the outcomes following detoxification and psychosocial rehabilitation of heroindependent patients. Objective. To compare the demographic, clinical, forensic and ...
    • Participants’ perspectives of weekly telephonic mood monitoring in South Africa : a feasibility study 

      Van der Watt, A. S. J.; Roos, T.; Beyer, C.; Seedat, S. (BioMed Central, 2018-02-22)
      Background: Mood and anxiety disorders have a high lifetime prevalence, and their chronicity adds to the management burden of already scarce and strained mental health care resources, particularly in developing countries. ...
    • Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture 

      Davis, Lea K.; Yu, Dongmei; Keenan, Clare L.; Gamazon, Eric R.; Konkashbaev, Anuar I.; Derks, Eske M.; Neale, Benjamin M.; Yang, Jian; Lee, S. Hong; Evans, Patrick; Barr, Cathy L.; Bellodi, Laura; Benarroch, Fortu; Berrio, Gabriel Bedoya; Bienvenu, Oscar J.; Bloch, Michael H.; Blom, Rianne M.; Bruun, Ruth D.; Budman, Cathy L.; Camarena, Beatriz; Campbell, Desmond; Cappi, Carolina; Silgado, Julio C. Cardona; Cath, Danielle C.; Cavallini, Maria C.; Chavira, Denise A.; Chouinard, Sylvain; Conti, David. V.; Cook, Edwin H.; Coric, Vladimir; Cullen, Bernadette A.; Deforce, Dieter; Delorme, Richard; Dion, Yves; Edlund, Christopher K.; Egberts, Karin; Falkai, Peter; Fernandez, Thomas V.; Gallagher, Patience J.; Garrido, Helena; Geller, Daniel; Girard, Simon L.; Grabe, Hans J.; Grados, Marco A.; Greenberg, Benjamin D.; Gross-Tsur, Varda; Haddad, Stephen; Heiman, Gary A.; Hemmings, Sian M. J.; Hounie, Ana G.; Illmann, Cornelia; Jankovic, Joseph; Jenike, Michael A.; Kennedy, James L.; King, Robert A.; Kremeyer, Barbara; Kurlan, Roger; Lanzagorta, Nuria; Leboyer, Marion; Leckman, James F.; Lennertz, Leonhard; Liu, Chunyu; Lochner, Christine; Lowe, Thomas L.; Macciardi, Fabio; McCracken, James T.; McGrath, Lauren M.; Mesa Restrepo, Sandra C.; Moessner, Rainald; Morgan, Jubel; Muller, Heike; Murphy, Dennis L.; Naarden, Allan L.; Ochoa, William Cornejo; Ophoff, Roel A.; Osiecki, Lisa; Pakstis, Andrew J.; Pato, Michele T.; Pato, Carlos N.; Piacentini, John; Pittenger, Christopher; Pollak, Yehuda; Rauch, Scott L.; Renner, Tobias J.; Reus, Victor I.; Richter, Margaret A.; Riddle, Mark A.; Robertson, Mary M.; Romero, Roxana; Rosario, Maria C.; Rosenberg, David; Rouleau, Guy A.; Ruhrmann, Stephan; Ruiz-Linares, Andres; Sampaio, Aline S.; Samuels, Jack; Sandor, Paul; Sheppard, Brooke; Singer, Harvey S.; Smit, Jan H.; Stein, Dan J.; Strengman, E.; Tischfield, Jay A.; Valencia Duarte, Ana V.; Vallada, Homero; Van Nieuwerburgh, Filip; Veenstra-VanderWeele, Jeremy; Walitza, Susanne; Wang, Ying; Wendland, Jens R.; Westenberg, Herman G. M.; Shugart, Yin Yao; Miguel, Euripedes C.; McMahon, William; Wagner, Michael; Nicolini, Humberto; Posthuma, Danielle; Hanna, Gregory L.; Heutnik, Peter; Denys, Damiaan; Arnold, Paul D.; Oostra, Ben A.; Nestadt, Gerald; Freimer, Nelson B.; Pauls, David L.; Wray, Naomi R.; Stewart, S. Evelyn; Mathews, Carol A.; Knowles, James A.; Cox, Nancy J.; Shcarf, Jeremiah M. (PLoS, 2013-10)
      The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated ...
    • Patterns of substance use in South Africa : results from the South African Stress and Health study 

      Van Heerden, Margaretha S.; Grimsrud, Anna T.; Seedat, Soraya; Myer, Landon; Williams, David R.; Stein, Dan J. (Health and Medical Publishing Group (HMPG), 2009)
      Background. There are limited data on substance use in South Africa. We describe patterns of substance use based on recent, nationally representative data. Methods. Data were derived from the 2002-2004 South African Stress ...
    • Perceived discrimination and mental health disorders : the South African Stress and Health study (SASH) 

      Moomal, Hashim; Jackson, Pamela B.; Stein, Dan J.; Herman, Allen; Myer, Landon; Seedat, Soraya; Madela-Mntla, Edith; Williams, D. R. (Health and Medical Publishing Group (HMPG), 2009)
      Objectives. To describe the demographic correlates of perceived discrimination and explore the association between perceived discrimination and psychiatric disorders. Design. A national household survey was conducted between ...
    • Perceptions of alcohol use in the context of HIV treatment : a qualitative study 

      Madhombiro, Munyaradzi; Marimbe-Dube, Bazondlile; Dube, Michelle; Kaiyo-Utete, Malinda; Paradzai, Angeline; Chibanda, Dixon; Rusakaniko, Simbarashe; Van Der Watt, A. S. J.; Seedat, Soraya (Dove Medical Press, 2018)
      Background: Alcohol use is associated with poor HIV treatment outcomes. This study aimed to understand patients’ perceptions of the impact of alcohol use in the context of HIV care. Methods: The study design was a descriptive ...