Browsing Research Articles (Physiological Sciences) by Title
Now showing items 1-20 of 65
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Anti-inflammatory cellular targets on neutrophils elucidated using a novel cell migration model and confocal microscopy : a clinical supplementation study
(BioMed Central, 2018-01-05)Background In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary ... -
Aspalathin protects the heart against hyperglycemia-induced oxidative damage by up-regulating Nrf2 expression
(MDPI, 2017)Aspalathin (ASP) can protect H9c2 cardiomyocytes against high glucose (HG)-induced shifts in myocardial substrate preference, oxidative stress, and apoptosis. The protective mechanism of ASP remains unknown. However, as ... -
Assessment of endocrine stress status in athletes – new twists to the tale
(Health and Medical Publishing Group, 2005)Objective. Cortisol concentration at rest seems to be an insensitive marker for endocrine stress status in athletes. Therefore, the aim of this review was to identify potentially more sensitive parameters which could ... -
Bcl‑2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose‑dependent toxicity and resistance
(BioMed Central, 2015-10)Background: Cisplatin is the main chemotherapeutic drug for the treatment of cervical cancers, however resistance to cisplatin is increasingly common and therefore has limited the efficacy and use of this drug in the ... -
Bone mineral density in people living with HIV : a narrative review of the literature
(BioMed Central, 2017-07-26)Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a ... -
C-reactive protein is elevated only in high creatine kinase responders to muscle damaging exercise
(Frontiers Media, 2017-02-11)The purpose of this study was to investigate if exertional rhabdomyolysis induced by an acute bout of plyometric exercise in untrained individuals was associated with histological characteristics of skeletal muscle, creatine ... -
Cardio-metabolic effects of HIV protease inhibitors (Lopinavir/Ritonavir)
(PLoS, 2013-11)Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term side effects may include the onset of insulin resistance and cardiovascular diseases. However, the underlying molecular mechanisms responsible ... -
Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?
(BMC (part of Springer Nature), 2018-10-16)It is a well-known fact that DHEA declines on ageing and that it is linked to ageing-related neurodegeneration, which is characterised by gradual cognitive decline. Although DHEA is also associated with inflammation in ... -
Chemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironment
(Frontiers Media, 2018-12-11)Excess adipose tissue is a hallmark of an overweight and/or obese state as well as a primary risk factor for breast cancer development and progression. In an overweight/obese state adipose tissue becomes dysfunctional due ... -
Commentary on : "A common origin for immunity and digestion"
(Frontiers Media, 2015-05)No abstract -
A dietary survey of free living middle aged White males in the Western Cape
(Health and Medical Publishing Group (HMPG), 1974)[No abstract available] -
Distinct gender differences in anthropometric profiles of a peri-urban South African HIV population : a cross sectional study
(BioMed Central, 2015-02)Background: Highly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIV-positive individuals. Since there are concerns regarding HAART-mediated onset of cardio-metabolic ... -
Domesticating cancer : an evolutionary strategy in the war on cancer
(Frontiers Media, 2017)Since cancer shares the same molecular machinery as the host, most therapeutic interventions that aim to target cancer would inadvertently also adversely affect the host. In addition, cancer continuously evolves, streamlining ... -
The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart : the involvement of the PI3-Kinase signaling pathway
(BioMed Central, 2009-05)We have previously shown that dietary red palm oil (RPO) supplementation improves functional recovery in hearts subjected to ischaemia/reperfusion-induced injury. Unfortunately, the cellular and molecular mechanisms ... -
The effect of protein energy malnutrition on plasma renin and oedema in the pig
(Health & Medical Publishing Group, 1977)Five litter mate male pigs, aged 7 days and fed a standard Pig Industry Board diet containing 190 g/kg dry mass of digestible protein, were compared with 10 male pigs from two litters fed a protein deficient diet (50 g/kg) ... -
Efficacy of lantibiotic treatment of staphylococcus aureus-induced skin infections, monitored by in vivo bioluminescent imaging
(American Society for Microbiology, 2016)Staphylococcus aureus is a bacterial pathogen responsible for the majority of skin and soft tissue infections. Antibiotics are losing their efficacy as treatment for skin and soft tissue infections as a result of increased ... -
Endocrine and immune effects of dexamethasone in unilateral total knee replacement
(SAGE Publications, 2006)The effect of acute pre-surgery dexamethasone treatment on the inflammatory immune and endocrine responses to orthopaedic surgery was investigated. Whole blood samples were obtained before and 5 days after surgery for ... -
Enhanced therapeutic efficacy in cancer patients by short-term fasting : the autophagy connection
(Frontiers Media, 2016)Preclinical studies suggest that fasting prior to chemotherapy may be an effective strategy to protect patients against the adverse effects of chemo-toxicity. Fasting may also sensitize cancer cells to chemotherapy. It is ... -
Experimental conditions for vacuum ultraviolet laser spectroscopy
(Academy of Science for South Africa, 2005)An efficient wavelength-tunable vacuum ultraviolet (VUV) laser source has been developed at our institute in recent years. This laser source works on the principle of sum-frequency mixing of dye laser pulses in a magnesium ... -
Gender differences in metabolic risk factor prevalence in a South African student population
(Clinics Cardiv Publishing, 2009-06)We determined selected risk factors for the metabolic syndrome and assessed the metabolic risk status (using IDF criteria) of third-year physiology students at Stellenbosch University (88 males and 178 females). Outcome ...
