1H-MRS in autism spectrum disorders: A systematic meta-analysis

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dc.contributor.author Ipser J.C.
dc.contributor.author Syal S.
dc.contributor.author Bentley J.
dc.contributor.author Adnams C.M.
dc.contributor.author Steyn B.
dc.contributor.author Stein D.J.
dc.date.accessioned 2012-08-17T12:24:18Z
dc.date.available 2012-08-17T12:24:18Z
dc.date.issued 2012
dc.identifier.citation Metabolic Brain Disease
dc.identifier.citation 27
dc.identifier.citation 3
dc.identifier.citation 275
dc.identifier.citation 287
dc.identifier.issn 8857490
dc.identifier.other 10.1007/s11011-012-9293-y
dc.identifier.uri http://hdl.handle.net/10019.1/49253
dc.description Article
dc.description.abstract We conducted a systematic review and metaanalysis of proton magnetic resonance spectroscopy (1HMRS) studies comparing autism spectrum disorder (ASD) patients with healthy controls, with the aim of profiling ASD-associated changes in the metabolites N-acetylaspartate (NAA) and Creatine (Cr). Meta-regression models of NAA and Cr levels were employed, using data from 20 eligible studies (N0852), to investigate age-dependent differences in both global brain and region-specific metabolite levels, while controlling for measurementmethod (Cr-ratio versus absolute concentrations). Decreased NAA concentrations that were specific to children were found for whole-brain grey and white matter. In addition, a significant decrease in NAA was evident across age categories in the parietal cortex, the cerebellum, and the anterior cingulate cortex. Higher levels of Cr were observed for ASD adults than children in global grey matter, with specific increases for adults in the temporal lobe and decreased Cr in the occipital lobe in children. No differences were found for either NAA or Cr in the frontal lobes. These data provide some evidence that ASD is characterized by age-dependent fluctuations in metabolite levels across the whole brain and at the level of specific regions thought to underlie ASD-associated behavioural and affective deficits. Differences in Cr as a function of age and brain region suggests caution in the interpretation of Cr-based ratio measures of metabolites. Despite efforts to control for sources of heterogeneity, considerable variability in metabolite levels was observed in frontal and temporal regions, warranting further investigation. © Springer Science+Business Media, LLC 2012.
dc.subject Asperger syndrome
dc.subject Autism spectrum disorders
dc.subject Creatine
dc.subject Magnetic resonance imaging
dc.subject Meta-analysis
dc.subject NAA
dc.title 1H-MRS in autism spectrum disorders: A systematic meta-analysis


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