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    • Correcting the bias of empirical frequency parameter estimators in codon models 

      Kosakovsky Pond, Sergei; Delport, Wayne; Muse, Spencer V.; Scheffler, Konrad (Public Library of Science -- PLOS, 2010-07)
      Markov models of codon substitution are powerful inferential tools for studying biological processes such as natural selection and preferences in amino acid substitution. The equilibrium character distributions of these ...