Now showing items 1-2 of 2

    • Benchmarking multi-rate codon models 

      Delport, Wayne; Scheffler, Konrad; Gravenor, Mike B.; Muse, Spencer V.; Pond, Sergei Kosakovsky (Public Library of Science, 2010-07-21)
      The single rate codon model of non-synonymous substitution is ubiquitous in phylogenetic modeling. Indeed, the use of a non-synonymous to synonymous substitution rate ratio parameter has facilitated the interpretation of ...

    • Codon test : modeling amino acid substitution preferences in coding sequences 

      Delport, Wayne; Scheffler, Konrad; Botha, Gordon; Gravenor, Mike B.; Muse, Spencer V.; Pond, Sergei L. Kosakovsky (PLOS Computational Biology, 2010-08)
      Codon models of evolution have facilitated the interpretation of selective forces operating on genomes. These models, however, assume a single rate of non-synonymous substitution irrespective of the nature of amino acids ...