SUNScholar
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Faculty of Science
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Department of Biochemistry
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Doctoral Degrees (Biochemistry)
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Now showing items 1-20 of 26

Bioaffinity separation using ligand-modified pluronic and synthetic membranes

Govender, Selvakumaran (Stellenbosch : University of Stellenbosch, 2011-10)

ENGLISH ABSTRACT: A new membrane based affinity separation system that is bio-specific, biocompatible, well characterised and capable of being regenerated or re-used is described. The amphiphilic non-ionic surfactant ...
A biochemical study of tissue type plasminogen activator in bovine milk

Cilliers, Frans Pieter (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: This study describes: 1. The isolation and the purification of tissue type plasminogen activator and urokinase plasminogen activator in bovine milk. 2. The biochemical characterisation of tissue type ...
Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays

Marnewick, Jeanine Lucasta (Stellenbosch : Stellenbosch University, 2004-12)

ENGLISH ABSTRACT: This thesis provides the first scientific evidence on the cancer modulating properties of two unique South African herbal teas, rooibos (Aspalathus Iinearis) and honeybush (Cyclopia intermedia) utilizing ...
Cape baboon Cytochrome P450 11β-hydroxylases : the characterization of two functional enzymes

Brown, Natasja (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: This study: 1. Describes the localization of CYP11B1 in the Cape baboon adrenal gland using Western blot analysis. CYP11B1 was localized to the adrenal cortex and medulla. 2. Describes the catalytic ...
Characteristics and adaptation of skeletal muscle to endurance exercise

Kohn, Tertius A. (Stellenbosch : University of Stellenbosch, 2011-10)

ENGLISH ABSTRACT: Skeletal muscle adapts to stimuli by modifying structural and metabolic protein expression. Furthermore, a muscle group may vary within itself to accommodate specialisation in regions. Structural and ...
A comparative analysis of the G1/S transition control in kinetic models of the eukaryotic cell cycle

Conradie, Riaan (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: The multiplication of cells proceeds through consecutive phases of growth and division (G1, S, G2 and M phases), in a process known as the cell cycle. The transition between these phases is regulated ...
Comparative cross-species analysis of detailed kinetic models of glycolysis

Du Preez, Franco B. (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: With the recent advances in the field of molecular biology, there is an increased need to integrate data on the various constituents of the cell in kinetic models that can predict and describe cellular ...
Comparative study of the molecular mechanism of action of the synthetic progestins, Medroxyprogesterone acetate and Norethisterone acetate

Africander, Donita Jean (Stellenbosch : University of Stellenbosch, 2010-03)

ENGLISH ABSTRACT: Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives (norethisterone enanthate (NET-EN); norethisterone acetate (NETA)), are used by millions of women as contraceptives and in ...
Comparison of two CYP17 isoforms : implications for cortisol production in the South African Merino

Hough, Denise (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: This study describes: • the comparison of the enzymatic activities of the two ovine cytochrome P450 17 - hydroxylase/17,20-lyase (CYP17) isoforms expressed in non-steroidogenic COS-1 cells. The Km and ...
Control analysis of mixed populations of gluconobacter oxydans and saccharomyces cerevisiae

Malherbe, Christiaan Johannes (Stellenbosch : University of Stellenbosch, 2010-12)

ENGLISH ABSTRACT: In the last decade a need arose to find a theoretical framework capable of gaining a quantitative understanding of ecosystems. Control analysis was proposed as a suitable candidate for the analysis of ...
Coupling kinetic models and advection-diffusion equations to model vascular transport in plants, applied to sucrose accumulation in sugarcane

Uys, Lafras (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: The sugarcane stalk, besides being the main structural component of the plant, is also the major storage organ for carbohydrates. Sucrose forms the bulk of stored carbohydrates. Previous studies have ...
The effect of ultraviolet-C treatment on the biochemical composition of beer

Mfa-Mezui, Antoine Aime (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: This study describes: · Development of analytical tools to investigate the light struck flavour (LSF) in beer by Gas chromatography mass spectrometry (GCMS) and by liquid chromatography mass spectrometry/mass ...
Identification of candidate genes and testing for association with tuberculosis in humans

Babb, Chantal Louiza (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: This research investigated human candidate genes for susceptibility to tuberculosis and the effect of various factors on time to sputum conversion in the admixed South African Coloured (SAC) population. ...
The influence of 3βHSD on adrenal steroidogenesis and the factors which influence its activity

Goosen, Pierre (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: This study describes: - the characterization and comparison of the enzymatic activity of both Angora and ovine 3βHSD expressed in non-steroidogenic COS-1 cells. The apparent Km and Vmax values for ...
The influence of dual CYP17 expression on adrenal steroidogenesis in the South African Angora Goat

Storbeck, Karl-Heinz (Stellenbosch : Stellenbosch University, 2008-12)

This study describes: • the cloning and sequencing of cytochrome P450 17 -hydroxylase/17,20 lyase (CYP17), 3 -hydroxysteroid dehydrogenase (3 HSD) and cytochrome b5 from the South African Angora goat; • the identification ...
The isolation and charcterisation of ovine liver cytochrome b₅

Lombard, Nicolaas (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: This dissertation describes how the isolation and characterisation of ovine liver cytochrome b5 was accomplished by referring to the following goals achieved in this study: - The optimisation of the ...
The mammalian type II gonadotropin-releasing hormone receptor : cloning, distribution and role in gonadotropin gene expression

Van Biljon, Wilma (Stellenbosch : University of Stellenbosch, 2006-12)

ENGLISH ABSTRACT: Gonadotropin-releasing hormone (GnRH) is well known as the central regulator of the reproductive system through its stimulation of gonadotropin synthesis and release from the pituitary via binding to ...
Molecular phylogenetic relationships within the subtribe Disinae (Orchidaceae) and their taxonomic, phytogeographic and evolutionary implications

Bytebier, Benny (Benny Leopold Germaine) (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: Twenty five years after the last major morphological revision, phylogenetic relationships were inferred on the basis of a new DNA dataset for the African orchid subtribe Disinae, which includes the large ...
Mycotoxicological properties of fusarium verticillioides and the fumonisins : mechanisms and implications for setting risk assessment parameters in humans

Gelderblom, Wentzel Christoffel Andreas (Stellenbosch : Stellenbosch University, 2009-03)

The fumonisin mycotoxins are known to be the causative principle for several animal diseases and are associated with the development of liver and oesophagus cancer and neural tube defects in humans. The thesis focuses ...
Qualitative structure-activity relationships of the major tyrocidines, cyclic decapeptides from Bacillus aneurinolyticus

Spathelf, Barbara Marianne (Stellenbosch : University of Stellenbosch, 2010-03)

ENGLISH ABSTRACT: The need for alternative or supplementary treatments due to the global problem of microbial resistance towards conventional antimicrobials may be met by the development of novel drugs based on antimicrobial ...