Doctoral Degrees (Paediatrics and Child Health)

Neuro-imaging in paediatric HIV, a MRI/DTI study

Ackermann, Christelle (Stellenbosch : Stellenbosch University, 2020-03)

ENGLISH ABSTRACT: The HIV epidemic has been largely controlled by antiretroviral treatment (ART) which improves neurodevelopmental outcomes. Nevertheless, many HIV-infected (HIV+) children on long-term treatment may have ...

And therapeutic outcomes lopinavir-ritonavir and a rifampicin containing anti-tuberculosis pharmacokinetics in children with tuberculosis/hiv co-infection treated with regimen

Rabie, Helena (Stellenbosch : Stellenbosch University, 2019-10-15)

ENGLISH ABSTRACT: Background Despite the scale-up of the prevention of mother to child transmission of HIV, an estimated 240,000 children were infected in 2013. Currently, The Joint United Nations Programme on HIV and ...

Neurodevelopmental and behavioural outcome of the HIV-exposed uninfected infant and child

Springer, Priscilla Estelle (Stellenbosch : Stellenbosch University., 2020-03)

ENGLISH ABSTRACT: The first 1000 days of life represents a crucial phase for cognitive, language and emotional development. Indeed, early childhood development provides a foundation for educational and vocational success. ...

Addressing critical knowledge gaps to improve and shorten multidrug-resistant tuberculosis treatment regimens in children

Garcia-Prats, Anthony Joseph (Stellenbosch : Stellenbosch University, 2018-12)

ENGLISH ABSTRACT: Multidrug-resistant (MDR) tuberculosis (TB), defined as TB disease or infection caused by Mycobacterium tuberculosis with resistance to at least both isoniazid and rifampicin, threatens global TB ...

Innovative strategies to improve the diagnosis of intrathoracic tuberculosis in children

Walters, Elisabetta (Stellenbosch : Stellenbosch University, 2018-12)

ENGLISH ABSTRACT: Paediatric tuberculosis (TB) contributes approximately 10% of the global TB burden, with over one million estimated new cases and 253,000 TB-related deaths in children during 2016. Paediatric TB is a ...

The impact of the HPTN 071 (PopART) intervention on mortality and AIDS related morbidity amongst HIV positive adults in South Africa

Bock, Peter (Stellenbosch : Stellenbosch University, 2018-03)

ENGLISH ABSTRACT: In 2015 WHO recommended antiretroviral treatment (ART) for all HIV-positive individuals regardless of CD4 count and set a target for Universal Access to ART, that >80% of HIV-positive individuals should ...

Mathematical modelling to project the impact of interventions targeted to previously treated individuals on the trajectory of the tuberculosis epidemic in high tuberculosis prevalence settings

Marx, Florian Michael (Stellenbosch : Stellenbosch University, 2018-03)

ENGLISH ABSTRACT: Better strategies are needed to reduce Mycobacterium tuberculosis (M.tb) transmission in tuberculosis (TB) high-incidence settings. Targeting additional control interventions towards groups at highest TB ...

How can virtual implementation modelling inform the scale-up of new molecular diagnostic tools for tuberculosis?

Dunbar, Rory (Stellenbosch : Stellenbosch University, 2018-03)

ENGLISH ABSTRACT: The aim of this dissertation was to develop an operational model to explain why the expected increase in the number of tuberculosis (TB) cases detected was not found in our empirical study, Policy ...

Evaluating the impact of an Xpert® MTB/RIF- based TB diagnostic algorithm in a routine operational setting in Cape Town

Naidoo, Prenavum (Stellenbosch : Stellenbosch University, 2017-03)

ENGLISH SUMMARY: Decades of reliance on slow, inaccurate diagnostic tests have contributed to poor case detection and impeded tuberculosis (TB) control efforts globally. The development of an accurate, rapid molecular ...

Determinants of healthcare-associated infection among hospitalized children

Dramowski, Angela (Stellenbosch : Stellenbosch University, 2017-03)

ENGLISH SUMMARY: Healthcare-associated infection (HAI) is the most frequent complication of hospitalization resulting in suffering, excess mortality and increased healthcare costs. Although paediatric HAI burden and impact ...

Prevention and treatment of perinatal and infant tuberculosis in the HIV era

Bekker, Adrie (Stellenbosch : Stellenbosch University, 2016-11-18)

ENGLISH ABSTRACT : Infants (<12 months) born to women with tuberculosis are at high risk of Mycobacterium tuberculosis (M. tuberculosis) exposure, infection and disease early in life. In settings with high prevalence of ...

Social and contextual factors affecting HIV-infected women’s feeding practices for their infants in normal practice settings : effects on growth and morbidity

Zunza, Moleen (Stellenbosch : Stellenbosch University, 2016-03)

ENGLISH ABSTRACT: the significant reduction in HIV transmission through breastfeeding by antiretroviral treatment guided the current recommendations favouring breastfeeding which has to be continued until 12 months of ...

Pharmacokinetics and safety of first -- and second--line anti-- tuberculosis drugs in children

Thee, Stephanie (Stellenbosch : Stellenbosch University, 2015-12)

ENGLISH ABSTRACT : The global burden of tuberculosis (TB) in children is high with a high morbidity and mortality, especially amongst young and HIV-‐infected children. The emerging epidemic of multidrug-‐resistant ...

Improving early diagnosis of tuberculous meningitis in children

Solomons, Regan Shane (Stellenbosch : Stellenbosch University, 2015-12)

ENGLISH SUMMARY: Due to the sub-optimal performance of definite diagnostic tests, the early identification of paediatric TBM suspects relies on a thorough assessment of all the evidence derived from a careful history, ...

Bronchoscopic assessment and management of children presenting with clinically significant airway obstruction due to tuberculosis

Goussard, Pierre (Stellenbosch : Stellenbosch University, 2015-04)

ENGLISH ABSTRACT: Tuberculosis (TB) in children is a common infectious disease in the world affecting approximately 550 000 children annually and contributing to approximately 10-15% of the TB caseload. The estimate is ...