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The potential toxic effects of chronic doxorubicin treatment on the rat pancreas and the role of ghrelin in this context
(Stellenbosch : Stellenbosch University, 2018-03)
ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX), is a chemotherapeutic drug that has potent anti-neoplastic actions. It is for this reason that it remains one of the most widely used chemotherapeutic agents that has led ...
Neuro- and immunomodulatory effects of Sceletium tortuosum
(Stellenbosch : Stellenbosch University, 2018-03)
ENGLISH ABSTRACT: Chronic lifestyle stress translates to chronic physiological and psychological conditions. Continual stress-response activation plays a key role in the development of inflammatory diseases, such as diabetes, ...
Investigation into potential endocrine disruptive effects of Sceletium tortuosum
(Stellenbosch : Stellenbosch University, 2018-03)
ENGLISH ABSTRACT: Depression has been recognised by the World Health Organisation (WHO) as the leading cause of disability, affecting an estimated 300 million people globally. To date antidepressants are prescribed as the ...
Investigating the effects of chronic doxorubicin and ghrelin treatment on hepatic tissue
(Stellenbosch : Stellenbosch University, 2018-03)
ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX) is an effective and widely used chemotherapeutic agent. However, its toxicity on healthy tissue limits its usage. DOX is known to induce damage mainly via oxidative stress ...
TKTL1 plays a critical role in ameliorating intracellular oxidative stress under hyperglycemic conditions
(Stellenbosch : Stellenbosch University, 2018-03)
ENGLISH ABSTRACT: Diabetes is a growing, global concern, reaching a prevalence far beyond the projected
statistics. Hyperglycemia is a common denominator of type 1 and type 2 diabetes mellitus that
if left untreated, ...