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Modulation of oxidative stress and inflammation using a grape seed derived polyphenol
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Oxidative stress and inflammation are intricately interlinked, especially in the context of ageing/accelerated ageing, as well as several chronic disease states, where they are implicated as aetiological ...
Association between the metabolic syndrome and cancer risk : the potential role of fatty acids on body composition
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Background: Sub-Sahara Africa is experiencing an epidemiological transition with an increasing burden of non-communicable diseases (NCDs) including obesity, hypertension, insulin resistance (IR) and ...
Investigating Tau pathology in an in vitro model for Alzheimer’s disease
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Introduction
Alzheimer’s disease is a neurodegenerative disease of the brain and the leading cause of dementia globally. Severe cognitive and short term memory deficits are commonly associated with this ...
The association between the metabolic syndrome and bone mineral density in pre- and post-menopausal farm workers
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Introduction and aims: The prevalence of the metabolic syndrome (MetS) is increasing, both globally and in South Africa. Albeit so, limited data have been published in the South African context. One of ...
The nitric oxide donor Molsidomine shows therapeutic benefit toward muscle repair after an acute impact injury, in rats.
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Background: Muscle injuries are highly prevalent and arise from a multitude of situations. Trauma to the soft tissue is painful and debilitating and it requires extensive healing that often involves the ...
Utilising autophagy modulation to combat cell death resistance in Glioblastoma Multiforme
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH SUMMARY: Introduction: Globally, Glioblastoma Multiforme (GBM) presents as both the most prevalent and invasive form of Central Nervous System (CNS) malignancy. Patient life expectancy has remained largely unchanged ...
Cardio-metabolic effects of anti-retroviral treatment in the Cape Winelands region of South Africa
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Background: Although highly active antiretroviral therapy (HAART) has significantly improved the survival of human immunodeficiency virus (HIV)-infected patients there are increased concerns regarding the ...
The role of ketone bodies in autophagic flux, cellular energetics and injury-induced neurotoxicity
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Introduction. Alzheimer’s disease is the most common neurodegenerative disease and leading cause of dementia globally, with an increasing prevalence especially in developing countries such as South Africa. ...
Does cardioprotection by autophagy go beyond acute cardiotoxicity?
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Introduction and Aim
The discovery of Doxorubicin (DOX) in the 1960s has drastically improved the survival rates of cancer patients; however, its success is limited by dose-dependent cardiotoxicity. While ...
Development of a transendothelial shuttle by macrophage modification
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Background: Targeted stem cell delivery via macrophage modification is a novel and relatively non-invasive therapeutic intervention. Monocytes circulate through the vasculature and infiltrate damaged ...