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Now showing items 31-40 of 48
Association between cancer, adipose tissue and selected systemic markers : a possible classification according to body shape
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Background: The metabolic syndrome (MetS) is a cluster of risk factors associated with an increased risk of developing chronic diseases of lifestyle, and has more recently been associated with cancer risk. ...
Are early proteomic and metabolic changes induced by long-term sugar-sweetened beverage consumption the key to unlocking the cardio-metabolic pandemic?
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: INTRODUCTION: Cardio-metabolic diseases (e.g. type 2 diabetes mellitus) are a major cause of
mortality worldwide. The incidence of cardio-metabolic diseases continues to increase, especially in low and ...
Investigating differential non-oxidative glucose-utilizing pathway gene expression as a novel diagnostic tool for type 2 diabetes
(Stellenbosch : Stellenbosch University, 2013-12)
ENGLISH ABSTRACT: Context: Despite the availability and accessibility of current diagnostic tools, diabetes
remains largely under-diagnosed. Biological limitations, discordant assays and conflicting
diagnostic thresholds ...
Investigating the effects of diet-induced obesity on acute Doxorubicin-induced cardiotoxicity in a tumour-bearing model
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Introduction: Obesity is a well-known global pandemic that is fundamentally caused by an energy imbalance between calories consumed and calories expended. A major consequence to obesity are metabolic ...
Potential for modulation of cancer-associated oxidative stress : an in vitro investigation
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: While cancer is a chronic, complex disease associated with a multitude of steps in its initiation and progression, all cancers generally have similar underlying maladaptive physiological mechanisms which ...
Dynamic interactions between skeletal muscle and breast cancer cells following chemotherapeutic treatment
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Background: Breast cancer is the most common cancer found among women of South
Africa with the prominent effective form of treatment being chemotherapy. Many cancer
patients receiving chemotherapeutic ...
A matter of life or death : autophagy in the context of prolonged doxorubicin therapy
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Introduction
Doxorubicin (DOX) is an effective treatment against a variety of cancers, and thus remains a commonly used chemotherapeutic drug. The chief side effect of DOX treatment is cardiotoxicity. ...
The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: Introduction: Breast cancer is frequently diagnosed in women in both developed and developing countries and poses a major health problem throughout the world. The current standard treatment for breast ...
The role of lipoteichoic acid on amyloidogenesis and its effect on erythrocytes and platelets
(Stellenbosch : Stellenbosch University, 2019-12)
ENGLISH ABSTRACT: Hypercoagulation and amyloidogenesis are commonly known as hallmarks for inflammation. Hypercoagulation and amyloidogenesis are linked to quite a few communicable and non-communicable ailments such as ...
Investigating the amyloidogenic potential of serum amyloid a in type ii diabetes mellitus
(Stellenbosch : Stellenbosch University, 2019-12)
ENGLISH ABSTRACT: Introduction: Type II Diabetes Mellitus (T2DM) is a non-communicable disease associated with chronic low-grade inflammation and persistent activation of the acute phase response (APR). Serum amyloid A ...