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Now showing items 11-20 of 48
Investigating Tau pathology in an in vitro model for Alzheimer’s disease
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Introduction
Alzheimer’s disease is a neurodegenerative disease of the brain and the leading cause of dementia globally. Severe cognitive and short term memory deficits are commonly associated with this ...
Elucidating the role of WDR47 in regulating neuronal migration, autophagy and tubulin dynamics
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction Normal cerebral cortex development depends on extensive neuronal migration during
embryogenesis, permitting the formation of accurate synaptic circuits and a highly ordered
laminar neocortex. ...
Establishing a rodent model of long-term consumption of sugar-sweetened beverages
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction- Cardiovascular complications contribute dramatically to morbidity and mortality incidence amongst individuals who have developed type 2 diabetes (T2D), with myocardial insulin resistance ...
The association between the metabolic syndrome and bone mineral density in pre- and post-menopausal farm workers
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Introduction and aims: The prevalence of the metabolic syndrome (MetS) is increasing, both globally and in South Africa. Albeit so, limited data have been published in the South African context. One of ...
The nitric oxide donor Molsidomine shows therapeutic benefit toward muscle repair after an acute impact injury, in rats.
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT: Background: Muscle injuries are highly prevalent and arise from a multitude of situations. Trauma to the soft tissue is painful and debilitating and it requires extensive healing that often involves the ...
Utilising autophagy modulation to combat cell death resistance in Glioblastoma Multiforme
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH SUMMARY: Introduction: Globally, Glioblastoma Multiforme (GBM) presents as both the most prevalent and invasive form of Central Nervous System (CNS) malignancy. Patient life expectancy has remained largely unchanged ...
Anthropometric characteristics and changes with HIV and ART in a randomly selected population in the Drakenstein region Western Cape Province
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Background - Highly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIVpositive
individuals. Since there are concerns regarding HAART-mediated onset of ...
Deubiquitination : does the answer to cardiotoxicity lie within the ubiquitin proteasome pathway
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: Introduction: Cardiotoxicity, a complication that arises from anthracycline use is one that has confounded scientists for decades. Attempts have been made to attenuate the development of this condition ...
Elucidation of molecular mechanisms that may contribute to polyphenol-induced effects on neutrophil chemokinesis
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: Grape-derived products are high in polyphenols and are known to have anti-oxidant and anti-inflammatory effects. In vivo studies in the context of muscle injury-induced inflammation have proven grape ...
The potential toxic effects of chronic doxorubicin treatment on the rat pancreas and the role of ghrelin in this context
(Stellenbosch : Stellenbosch University, 2018-03)
ENGLISH ABSTRACT: Introduction: Doxorubicin (DOX), is a chemotherapeutic drug that has potent anti-neoplastic actions. It is for this reason that it remains one of the most widely used chemotherapeutic agents that has led ...